The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice

Detalhes bibliográficos
Autor(a) principal: Villarreal, Cristiane Flora
Data de Publicação: 2013
Outros Autores: Funez, Mani Indiana, Cunha, Fernando de Queiroz, Parada, Carlos Amílcar, Ferreira, Sérgio Henrique
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12618
Resumo: Texto completo. Acesso restrito. p. 678–683
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spelling Villarreal, Cristiane FloraFunez, Mani IndianaCunha, Fernando de QueirozParada, Carlos AmílcarFerreira, Sérgio HenriqueVillarreal, Cristiane FloraFunez, Mani IndianaCunha, Fernando de QueirozParada, Carlos AmílcarFerreira, Sérgio Henrique2013-08-16T19:13:11Z2013-08-16T19:13:11Z20130091-3057http://www.repositorio.ufba.br/ri/handle/ri/12618v. 103, n. 3Texto completo. Acesso restrito. p. 678–683In recent years, evidence that sensitization of primary afferent nociceptors is an important event associated with chronic pain has been accumulating. The present study aimed to evaluate the participation of the prostaglandin and sympathetic components in the long-lasting sensitization of nociceptors induced by acute inflammation in mice. The intraplantar administration of carrageenan (100 μg) enhanced the nociceptive response to a small dose of PGE2 (9 ng/paw) or dopamine (3 μg/paw) up to 30 days later. This long-lasting sensitization is dependent on dopaminergic and prostanoid systems, since the pre-treatment with chlorpromazine (3 μg/paw) or indomethacin (100 μg/paw), but not local (6 μg/paw) or systemic (6 mg/kg) treatment with morphine, prevented its development. In agreement with this idea, the previous intraplantar administration of hyperalgesic doses of PGE2 or dopamine also induced long-lasting sensitization, which was fully prevented by pretreatment with EP4 and D1 antagonists, respectively. In summary, the present work described in mice a long-lasting sensitization of nociceptors, initiated by an acute inflammatory stimulation and dependent on dopaminergic and prostanoid systems. The present data represent new insights on the mechanisms of peripheral sensitization that could contribute to establish the basis of new therapeutic strategies for acute and chronic inflammatory pain.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-07-08T14:45:46Z No. of bitstreams: 1 888888888888888.pdf: 725561 bytes, checksum: b015821f6dbfe01e04994292aaf8c127 (MD5)Approved for entry into archive by Alda Lima da Silva(sivalda@ufba.br) on 2013-08-16T19:13:11Z (GMT) No. of bitstreams: 1 888888888888888.pdf: 725561 bytes, checksum: b015821f6dbfe01e04994292aaf8c127 (MD5)Made available in DSpace on 2013-08-16T19:13:11Z (GMT). No. of bitstreams: 1 888888888888888.pdf: 725561 bytes, checksum: b015821f6dbfe01e04994292aaf8c127 (MD5) Previous issue date: 2013SalvadorPharmacology Biochemistry and Behaviorhttp://dx.doi.org/10.1016/j.pbb.2012.11.006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInflammatory painNociceptive sensitizationChronic painDopamineProstaglandinPrimary afferent nociceptorsThe long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in micePharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL888888888888888.pdf888888888888888.pdfapplication/pdf725561https://repositorio.ufba.br/bitstream/ri/12618/1/888888888888888.pdfb015821f6dbfe01e04994292aaf8c127MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12618/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT888888888888888.pdf.txt888888888888888.pdf.txtExtracted texttext/plain34014https://repositorio.ufba.br/bitstream/ri/12618/3/888888888888888.pdf.txt046b8591aabc55865aa2c180940bcf6aMD53ri/126182022-07-05 14:02:51.085oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
dc.title.alternative.pt_BR.fl_str_mv Pharmacology Biochemistry and Behavior
title The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
spellingShingle The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
Villarreal, Cristiane Flora
Inflammatory pain
Nociceptive sensitization
Chronic pain
Dopamine
Prostaglandin
Primary afferent nociceptors
title_short The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
title_full The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
title_fullStr The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
title_full_unstemmed The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
title_sort The long-lasting sensitization of primary afferent nociceptors induced by inflammation involves prostanoid and dopaminergic systems in mice
author Villarreal, Cristiane Flora
author_facet Villarreal, Cristiane Flora
Funez, Mani Indiana
Cunha, Fernando de Queiroz
Parada, Carlos Amílcar
Ferreira, Sérgio Henrique
author_role author
author2 Funez, Mani Indiana
Cunha, Fernando de Queiroz
Parada, Carlos Amílcar
Ferreira, Sérgio Henrique
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Villarreal, Cristiane Flora
Funez, Mani Indiana
Cunha, Fernando de Queiroz
Parada, Carlos Amílcar
Ferreira, Sérgio Henrique
Villarreal, Cristiane Flora
Funez, Mani Indiana
Cunha, Fernando de Queiroz
Parada, Carlos Amílcar
Ferreira, Sérgio Henrique
dc.subject.por.fl_str_mv Inflammatory pain
Nociceptive sensitization
Chronic pain
Dopamine
Prostaglandin
Primary afferent nociceptors
topic Inflammatory pain
Nociceptive sensitization
Chronic pain
Dopamine
Prostaglandin
Primary afferent nociceptors
description Texto completo. Acesso restrito. p. 678–683
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-08-16T19:13:11Z
dc.date.available.fl_str_mv 2013-08-16T19:13:11Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12618
dc.identifier.issn.none.fl_str_mv 0091-3057
dc.identifier.number.pt_BR.fl_str_mv v. 103, n. 3
identifier_str_mv 0091-3057
v. 103, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/12618
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Pharmacology Biochemistry and Behavior
publisher.none.fl_str_mv Pharmacology Biochemistry and Behavior
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.pbb.2012.11.006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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