Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15897 |
Resumo: | p. 1325–1332 |
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Angelo, Ana Luiza DiasCavalcante, Lourianne NascimentoAbe Sandes, KiyokoMachado, Taisa Manuela BonfimLemaire, Denise CarneiroMalta, FernandaPinho, João Renato RebelloLyra, Luiz Guilherme CostaLyra, André CastroAngelo, Ana Luiza DiasCavalcante, Lourianne NascimentoAbe Sandes, KiyokoMachado, Taisa Manuela BonfimLemaire, Denise CarneiroMalta, FernandaPinho, João Renato RebelloLyra, Luiz Guilherme CostaLyra, André Castro2014-09-09T14:55:05Z2014-09-09T14:55:05Z20131807-5932http://repositorio.ufba.br/ri/handle/ri/15897v. 68, n. 10p. 1325–1332OBJECTIVES: Suppressor of cytokine signaling 3, myxovirus resistance protein and osteopontin gene polymorphisms may influence the therapeutic response in patients with chronic hepatitis C, and an association with IL28 might increase the power to predict sustained virologic response. Our aims were to evaluate the association between myxovirus resistance protein, osteopontin and suppressor of cytokine signaling 3 gene polymorphisms in combination with IL28B and to assess the therapy response in hepatitis C patients treated with pegylated-interferon plus ribavirin. METHOD: Myxovirus resistance protein, osteopontin, suppressor of cytokine signaling 3 and IL28B polymorphisms were analyzed by PCR-restriction fragment length polymorphism, direct sequencing and real-time PCR. Ancestry was determined using genetic markers. RESULTS: We analyzed 181 individuals, including 52 who were sustained virologic responders. The protective genotype frequencies among the sustained virologic response group were as follows: the G/G suppressor of cytokine signaling 3 (rs4969170) (62.2%); T/T osteopontin (rs2853744) (60%); T/T osteopontin (rs11730582) (64.3%); and the G/T myxovirus resistance protein (rs2071430) genotype (54%). The patients who had ≥3 of the protective genotypes from the myxovirus resistance protein, the suppressor of cytokine signaling 3 and osteopontin had a greater than 90% probability of achieving a sustained response (p<0.0001). The C/C IL28B genotype was present in 58.8% of the subjects in this group. The sustained virological response rates increased to 85.7% and 91.7% by analyzing C/C IL28B with the T/T osteopontin genotype at rs11730582 and the G/G suppressor of cytokine signaling 3 genotype, respectively. Genetic ancestry analysis revealed an admixed population. CONCLUSION: Hepatitis C genotype 1 patients who were responders to interferon-based therapy had a high frequency of multiple protective polymorphisms in the myxovirus resistance protein, osteopontin and suppressor of cytokine signaling 3 genes. The combined analysis of the suppressor of cytokine signaling 3 and IL28B genotypes more effectively predicted sustained virologic response than IL28B analysis alone.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-07T13:34:29Z No. of bitstreams: 1 10.6061clinics2013(10)06.pdf: 496812 bytes, checksum: d927f46be1656035b2fde06f6361dd1c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T14:55:05Z (GMT) No. of bitstreams: 1 10.6061clinics2013(10)06.pdf: 496812 bytes, checksum: d927f46be1656035b2fde06f6361dd1c (MD5)Made available in DSpace on 2014-09-09T14:55:05Z (GMT). No. of bitstreams: 1 10.6061clinics2013(10)06.pdf: 496812 bytes, checksum: d927f46be1656035b2fde06f6361dd1c (MD5) Previous issue date: 2013http://dx.doi.org/10.6061/clinics/2013(10)06reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CIL28BMxAOsteopontinSOCS3Genetic polymorphismsMyxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28BClinicsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINAL10.6061clinics2013(10)06.pdf10.6061clinics2013(10)06.pdfapplication/pdf496812https://repositorio.ufba.br/bitstream/ri/15897/1/10.6061clinics2013%2810%2906.pdfd927f46be1656035b2fde06f6361dd1cMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15897/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT10.6061clinics2013(10)06.pdf.txt10.6061clinics2013(10)06.pdf.txtExtracted texttext/plain37144https://repositorio.ufba.br/bitstream/ri/15897/3/10.6061clinics2013%2810%2906.pdf.txtc36a1da02ccd9638ca609f1fb076e3c7MD53ri/158972022-07-05 14:05:18.172oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| dc.title.alternative.pt_BR.fl_str_mv |
Clinics |
| title |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| spellingShingle |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B Angelo, Ana Luiza Dias Hepatitis C IL28B MxA Osteopontin SOCS3 Genetic polymorphisms |
| title_short |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| title_full |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| title_fullStr |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| title_full_unstemmed |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| title_sort |
Myxovirus resistance, osteopontin and suppressor of cytokine signaling 3 polymorphisms predict hepatitis C virus therapy response in an admixed patient population: comparison with IL28B |
| author |
Angelo, Ana Luiza Dias |
| author_facet |
Angelo, Ana Luiza Dias Cavalcante, Lourianne Nascimento Abe Sandes, Kiyoko Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Malta, Fernanda Pinho, João Renato Rebello Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author_role |
author |
| author2 |
Cavalcante, Lourianne Nascimento Abe Sandes, Kiyoko Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Malta, Fernanda Pinho, João Renato Rebello Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Angelo, Ana Luiza Dias Cavalcante, Lourianne Nascimento Abe Sandes, Kiyoko Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Malta, Fernanda Pinho, João Renato Rebello Lyra, Luiz Guilherme Costa Lyra, André Castro Angelo, Ana Luiza Dias Cavalcante, Lourianne Nascimento Abe Sandes, Kiyoko Machado, Taisa Manuela Bonfim Lemaire, Denise Carneiro Malta, Fernanda Pinho, João Renato Rebello Lyra, Luiz Guilherme Costa Lyra, André Castro |
| dc.subject.por.fl_str_mv |
Hepatitis C IL28B MxA Osteopontin SOCS3 Genetic polymorphisms |
| topic |
Hepatitis C IL28B MxA Osteopontin SOCS3 Genetic polymorphisms |
| description |
p. 1325–1332 |
| publishDate |
2013 |
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2013 |
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2014-09-09T14:55:05Z |
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2014-09-09T14:55:05Z |
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1807-5932 |
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v. 68, n. 10 |
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1807-5932 v. 68, n. 10 |
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openAccess |
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