Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/3433 |
Resumo: | P. 183-189,Abr /Jun. |
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Cavalcante, Fabiana A.Silva, Joelmir L. V.Carvalho, Viviane M. N.Camara, Celso de AmorimSilva, Tânia Maria Sarmento daPinto, Ângelo C.Vargas, Maria D.Silva, Bagnólia A.Cavalcante, Fabiana A.Silva, Joelmir L. V.Carvalho, Viviane M. N.Camara, Celso de AmorimSilva, Tânia Maria Sarmento daPinto, Ângelo C.Vargas, Maria D.Silva, Bagnólia A.2011-10-21T11:42:41Z2011-10-21T11:42:41Z20080102-695Xhttp://www.repositorio.ufba.br/ri/handle/ri/3433v. 18, n. 2.P. 183-189,Abr /Jun.O lapachol, α e β-lapachona são naftoquinonas obtidas de espécies de Tabebuia, apresentam propriedades antiinflamatória, antibacteriana, anticâncer e tripanossomicida. O objetivo deste trabalho foi investigar um possível efeito espasmolítico destas naftoquinonas em íleo de cobaia, uma vez que, outras naftoquinonas inibem a atividade contrátil de músculos lisos. O lapachol, α e β-lapachona inibiram as contrações fásicas induzidas tanto por carbacol (CI50 = 1,5 ± 0,2 x 10-4; 7,3 ± 0,9 x 10-5 e 3,2 ± 0,5 x 10-5 M, respectivamente) quanto por histamina (CI50 = 3,6± 0,5; 3,6 ± 0,7 e 3,3 ± 0,6 x 10-5 M, respectivamente). Estes compostos também relaxaram o íleo pré-contraído com KCl (CE50 = 1,2 ± 0,4; 4,3 ± 0,8 e 2,7 ± 0,2 x 10-5 M, respectivamente); carbacol (CE50 = 2,6 ± 0,7; 3,5 ± 0,5 e 2,2 ± 0,7 x 10-5 M, respectivamente) ou histamina (CE50 = 3,0 ± 0,8; 1,1 ± 0,3 e 3,3 ± 0,6 x 10-5 M, respectivamente) de maneira dependente de concentração. Este efeito é provavelmente devido à inibição do influxo de Ca2+ através dos canais de Ca2+ dependentes de voltagem (CaV). β-lapachona antagonizou (pD'2 = 5,73 ± 0,12; "slope" = 1,51 ± 0,05) as contrações induzidas por CaCl2 em meio despolarizante nominalmente sem Ca2+. O achado de que a β-lapachona inibiu as contrações tônicas induzidas por S-(-)-Bay K8644 (CE50 = 1,4 ± 0,1 x 10-5 M) é sugestivo que o CaV envolvido é o do tipo L. Em conclusão, lapachol, α e β-lapachona apresentam atividade espasmolítica não seletiva em íleo de cobaia, e β-lapachona exerce este efeito pelo bloqueio dos canais CaV tipo L.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-10-21T11:42:41Z No. of bitstreams: 1 07.pdf: 494878 bytes, checksum: b449b39e3b143ffe1c2421cdec5fb3d8 (MD5)Made available in DSpace on 2011-10-21T11:42:41Z (GMT). No. of bitstreams: 1 07.pdf: 494878 bytes, checksum: b449b39e3b143ffe1c2421cdec5fb3d8 (MD5) Previous issue date: 2008João PessoaLapacholα-lapachonaβ-lapachonaespasmolíticoíleo de cobaiaCaV tipo Lspasmolyticguinea-pig ileumL-type CaVSpasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channelsRevista Brasileira de Farmacognosiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL07.pdf07.pdfapplication/pdf494878https://repositorio.ufba.br/bitstream/ri/3433/1/07.pdfb449b39e3b143ffe1c2421cdec5fb3d8MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/3433/2/license.txt3098222478318a66d4f30d8fcd416beaMD52TEXT07.pdf.txt07.pdf.txtExtracted texttext/plain32464https://repositorio.ufba.br/bitstream/ri/3433/3/07.pdf.txt3299ce06fa0bc2a4b2dcd4e6efabb407MD53ri/34332022-07-05 14:03:30.513oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| dc.title.alternative.pt_BR.fl_str_mv |
Revista Brasileira de Farmacognosia |
| title |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| spellingShingle |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels Cavalcante, Fabiana A. Lapachol α-lapachona β-lapachona espasmolítico íleo de cobaia CaV tipo L spasmolytic guinea-pig ileum L-type CaV |
| title_short |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| title_full |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| title_fullStr |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| title_full_unstemmed |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| title_sort |
Spasmolytic activity of lapachol and its derivatives, α and β-lapachone, on the guinea-pig ileum involves blockade of voltage-gated calcium channels |
| author |
Cavalcante, Fabiana A. |
| author_facet |
Cavalcante, Fabiana A. Silva, Joelmir L. V. Carvalho, Viviane M. N. Camara, Celso de Amorim Silva, Tânia Maria Sarmento da Pinto, Ângelo C. Vargas, Maria D. Silva, Bagnólia A. |
| author_role |
author |
| author2 |
Silva, Joelmir L. V. Carvalho, Viviane M. N. Camara, Celso de Amorim Silva, Tânia Maria Sarmento da Pinto, Ângelo C. Vargas, Maria D. Silva, Bagnólia A. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cavalcante, Fabiana A. Silva, Joelmir L. V. Carvalho, Viviane M. N. Camara, Celso de Amorim Silva, Tânia Maria Sarmento da Pinto, Ângelo C. Vargas, Maria D. Silva, Bagnólia A. Cavalcante, Fabiana A. Silva, Joelmir L. V. Carvalho, Viviane M. N. Camara, Celso de Amorim Silva, Tânia Maria Sarmento da Pinto, Ângelo C. Vargas, Maria D. Silva, Bagnólia A. |
| dc.subject.por.fl_str_mv |
Lapachol α-lapachona β-lapachona espasmolítico íleo de cobaia CaV tipo L spasmolytic guinea-pig ileum L-type CaV |
| topic |
Lapachol α-lapachona β-lapachona espasmolítico íleo de cobaia CaV tipo L spasmolytic guinea-pig ileum L-type CaV |
| description |
P. 183-189,Abr /Jun. |
| publishDate |
2008 |
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2008 |
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2011-10-21T11:42:41Z |
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2011-10-21T11:42:41Z |
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0102-695X |
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v. 18, n. 2. |
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0102-695X v. 18, n. 2. |
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