TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior

Detalhes bibliográficos
Autor(a) principal: Libório, Tatiana Nayara
Data de Publicação: 2013
Outros Autores: Ferreira, Elisa Napolitano, Xavier, Flávia Caló de Aquino, Carraro, Dirce Maria, Kowalski, Luiz Paulo, Soares, Fernando Augusto, Nunes, Fabio Daumas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14963
Resumo: Texto completo: acesso restrito. p. 614–625
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spelling Libório, Tatiana NayaraFerreira, Elisa NapolitanoXavier, Flávia Caló de AquinoCarraro, Dirce MariaKowalski, Luiz PauloSoares, Fernando AugustoNunes, Fabio DaumasLibório, Tatiana NayaraFerreira, Elisa NapolitanoXavier, Flávia Caló de AquinoCarraro, Dirce MariaKowalski, Luiz PauloSoares, Fernando AugustoNunes, Fabio Daumas2014-05-14T11:45:27Z20132212-4403http://repositorio.ufba.br/ri/handle/ri/14963v. 116, n. 5Texto completo: acesso restrito. p. 614–625Objective: Possible differences in splicing variants of TGIF1 in oral squamous cell carcinoma (OSCC) have not yet been reported. This study analyzed the expression levels of different splicing variants of the TGIF1 gene in OSCC compared with nontumoral epithelium (NT) and the relationship with clinical-pathologic features of tumors. Study Design: Forty-eight frozen samples of OSCC and 17 of NT were analyzed using quantitative reverse transcription polymerase chain reaction. Results: TGIF1v2 and v8 are overexpressed in OSCC, whereas TGIF1v5 is underexpressed when compared with NT. Low TGIF1v8 expression was correlated with lower cellular differentiation, positive blood vascular invasion, advanced pathologic stage, and positive vascular lymphatic invasion of OSCC. TGIF1v8 is also related to overall survival over time, with lower values associated with an increased risk of cancer-related death. Conclusions: These data suggest that alternative splicing of TGIF1 is deregulated in OSCC, with overexpression of some splicing variants, especially TGIF1v8, which is associated with advanced stages of OSCC.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-14T13:12:53Z No. of bitstreams: 1 1-s2.0-S2212440313003970-main.pdf: 1110978 bytes, checksum: 71b79cb2d644627deec41dd3f69e348d (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-05-14T11:45:27Z (GMT) No. of bitstreams: 1 1-s2.0-S2212440313003970-main.pdf: 1110978 bytes, checksum: 71b79cb2d644627deec41dd3f69e348d (MD5)Made available in DSpace on 2014-05-14T11:45:27Z (GMT). No. of bitstreams: 1 1-s2.0-S2212440313003970-main.pdf: 1110978 bytes, checksum: 71b79cb2d644627deec41dd3f69e348d (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.oooo.2013.07.014reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACarcinomaOral ManifestationsTGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behaviorOral Surgery, Oral Medicine, Oral Pathology and Oral Radiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14963/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL1-s2.0-S2212440313003970-main.pdf1-s2.0-S2212440313003970-main.pdfapplication/pdf1110978https://repositorio.ufba.br/bitstream/ri/14963/1/1-s2.0-S2212440313003970-main.pdf71b79cb2d644627deec41dd3f69e348dMD51TEXT1-s2.0-S2212440313003970-main.pdf.txt1-s2.0-S2212440313003970-main.pdf.txtExtracted texttext/plain44940https://repositorio.ufba.br/bitstream/ri/14963/3/1-s2.0-S2212440313003970-main.pdf.txt9c8ca2a3194485f4285174b3c6d4b627MD53ri/149632022-07-05 14:03:11.852oai:repositorio.ufba.br:ri/14963VGVybW8gZGUgTGljZW4/YSwgbj9vIGV4Y2x1c2l2bywgcGFyYSBvIGRlcD9zaXRvIG5vIFJlcG9zaXQ/cmlvIEluc3RpdHVjaW9uYWwgZGEgVUZCQS4KCiBQZWxvIHByb2Nlc3NvIGRlIHN1Ym1pc3M/byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldSByZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIAplc3NlIHRlcm1vIGRlIGxpY2VuP2EsIGNvbmNlZGUgYW8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSAKbyBkaXJlaXRvIGRlIG1hbnRlciB1bWEgYz9waWEgZW0gc2V1IHJlcG9zaXQ/cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCBkZSBwcmVzZXJ2YT8/by4gCkVzc2VzIHRlcm1vcywgbj9vIGV4Y2x1c2l2b3MsIG1hbnQ/bSBvcyBkaXJlaXRvcyBkZSBhdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIApjb21vIHBhcnRlIGRvIGFjZXJ2byBpbnRlbGVjdHVhbCBkZXNzYSBVbml2ZXJzaWRhZGUuCgogUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVpPz9vLCBlc3NlIHRlcm1vIGRlIGxpY2VuP2EgCmVudGVuZGUgcXVlOgoKIE1hbnRlbmRvIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCByZXBhc3NhZG9zIGEgdGVyY2Vpcm9zLCBlbSBjYXNvIGRlIHB1YmxpY2E/P2VzLCBvIHJlcG9zaXQ/cmlvCnBvZGUgcmVzdHJpbmdpciBvIGFjZXNzbyBhbyB0ZXh0byBpbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1hPz9lcyBzb2JyZSBvIGRvY3VtZW50bwooTWV0YWRhZG9zIGVzY3JpdGl2b3MpLgoKIERlc3RhIGZvcm1hLCBhdGVuZGVuZG8gYW9zIGFuc2Vpb3MgZGVzc2EgdW5pdmVyc2lkYWRlIGVtIG1hbnRlciBzdWEgcHJvZHU/P28gY2llbnQ/ZmljYSBjb20gCmFzIHJlc3RyaT8/ZXMgaW1wb3N0YXMgcGVsb3MgZWRpdG9yZXMgZGUgcGVyaT9kaWNvcy4KCiBQYXJhIGFzIHB1YmxpY2E/P2VzIHNlbSBpbmljaWF0aXZhcyBxdWUgc2VndWVtIGEgcG9sP3RpY2EgZGUgQWNlc3NvIEFiZXJ0bywgb3MgZGVwP3NpdG9zIApjb21wdWxzP3Jpb3MgbmVzc2UgcmVwb3NpdD9yaW8gbWFudD9tIG9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudD9tIGFjZXNzbyBpcnJlc3RyaXRvIAphbyBtZXRhZGFkb3MgZSB0ZXh0byBjb21wbGV0by4gQXNzaW0sIGEgYWNlaXRhPz9vIGRlc3NlIHRlcm1vIG4/byBuZWNlc3NpdGEgZGUgY29uc2VudGltZW50bwogcG9yIHBhcnRlIGRlIGF1dG9yZXMvZGV0ZW50b3JlcyBkb3MgZGlyZWl0b3MsIHBvciBlc3RhcmVtIGVtIGluaWNpYXRpdmFzIGRlIGFjZXNzbyBhYmVydG8uCg==Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:11Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
dc.title.alternative.pt_BR.fl_str_mv Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
title TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
spellingShingle TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
Libório, Tatiana Nayara
Carcinoma
Oral Manifestations
title_short TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
title_full TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
title_fullStr TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
title_full_unstemmed TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
title_sort TGIF1 splicing variant 8 is overexpressed in oral squamous cell carcinoma and is related to pathologic and clinical behavior
author Libório, Tatiana Nayara
author_facet Libório, Tatiana Nayara
Ferreira, Elisa Napolitano
Xavier, Flávia Caló de Aquino
Carraro, Dirce Maria
Kowalski, Luiz Paulo
Soares, Fernando Augusto
Nunes, Fabio Daumas
author_role author
author2 Ferreira, Elisa Napolitano
Xavier, Flávia Caló de Aquino
Carraro, Dirce Maria
Kowalski, Luiz Paulo
Soares, Fernando Augusto
Nunes, Fabio Daumas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Libório, Tatiana Nayara
Ferreira, Elisa Napolitano
Xavier, Flávia Caló de Aquino
Carraro, Dirce Maria
Kowalski, Luiz Paulo
Soares, Fernando Augusto
Nunes, Fabio Daumas
Libório, Tatiana Nayara
Ferreira, Elisa Napolitano
Xavier, Flávia Caló de Aquino
Carraro, Dirce Maria
Kowalski, Luiz Paulo
Soares, Fernando Augusto
Nunes, Fabio Daumas
dc.subject.por.fl_str_mv Carcinoma
Oral Manifestations
topic Carcinoma
Oral Manifestations
description Texto completo: acesso restrito. p. 614–625
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-05-14T11:45:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14963
dc.identifier.issn.none.fl_str_mv 2212-4403
dc.identifier.number.pt_BR.fl_str_mv v. 116, n. 5
identifier_str_mv 2212-4403
v. 116, n. 5
url http://repositorio.ufba.br/ri/handle/ri/14963
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.oooo.2013.07.014
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