Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease

Detalhes bibliográficos
Autor(a) principal: Almeida, Neogélia Pereira
Data de Publicação: 2013
Outros Autores: Santana, Genoile Oliveira, Almeida, Tamara Celi, Bendicho, Maria Teresita Del Niño Jesus Fernandez, Lemaire, Denise Carneiro, Cardeal, Mauricio, Lyra, André Castro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15255
Resumo: p. 1-7
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spelling Almeida, Neogélia PereiraSantana, Genoile OliveiraAlmeida, Tamara CeliBendicho, Maria Teresita Del Niño Jesus FernandezLemaire, Denise CarneiroCardeal, MauricioLyra, André CastroAlmeida, Neogélia PereiraSantana, Genoile OliveiraAlmeida, Tamara CeliBendicho, Maria Teresita Del Niño Jesus FernandezLemaire, Denise CarneiroCardeal, MauricioLyra, André Castro2014-07-22T13:46:26Z2014-07-22T13:46:26Z20131756-0500http://repositorio.ufba.br/ri/handle/ri/15255v. 6, n. 1p. 1-7Background: Most Crohn’s disease (CD) genes discovered in recent years are associated with biological systems critical to the development of this disease. TGFB1 and IL10 are cytokines with important roles in CD. The aim of this study was to evaluate the association between CD, its clinical features and TGFB1 and IL10 gene polymorphisms. Methods: This case–control study enrolled 91 patients and 91 controls from the state of Bahia, Brazil. Five single nucleotide polymorphisms (SNPs) were studied in the TGFB1 gene (codon 10 T > C - rs1800470; codon 25 G > C - rs1800471) and IL10 gene (−1082 A > G - rs1800896; -819 T > C - rs1800871; -592 A > C - rs1800872). An analysis of the genetic polymorphisms was performed using a commercial kit. A comparison of allele frequencies and genotypes was estimated by calculating the odds ratio (OR) with a confidence interval adjusted via the Bonferroni test for a local alpha of 1%. A stratified analysis was applied for gender, race and smoking history. Patients with CD were characterized according to the Montreal classification. Results: The C allele and CC genotype of the TGFB1 gene rs1800470 were both significantly associated with CD. The stratified analysis showed no confounding factors for the co-variables of gender, race and smoking history. The IL10 gene rs1800896 G allele was significantly associated with age at diagnosis of CD, while the T allele of the IL10 gene rs1800871 was significantly associated with perianal disease. The SNPs rs1800871 and rs1800872 were in 100% linkage disequilibrium. Conclusions: TGFB1 gene polymorphisms may be associated with susceptibility to the development of CD, and IL10 gene polymorphisms appear to influence the CD phenotype in this admixed population.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-24T12:37:41Z No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5)Approved for entry into archive by Solange Gomes (soldella@ufba.br) on 2014-07-22T13:46:26Z (GMT) No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5)Made available in DSpace on 2014-07-22T13:46:26Z (GMT). No. of bitstreams: 1 1756-0500-6-387.pdf: 215699 bytes, checksum: ffb1f87439dfa7a5735fe0b041e27cf1 (MD5) Previous issue date: 2013http://dx.doi.org/10.1186/1756-0500-6-387reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACrohn’s diseasePolymorphismTGFB1IL10Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s diseaseBMC Research Notesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15255/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL1756-0500-6-387.pdf1756-0500-6-387.pdfapplication/pdf215699https://repositorio.ufba.br/bitstream/ri/15255/1/1756-0500-6-387.pdfffb1f87439dfa7a5735fe0b041e27cf1MD51TEXT1756-0500-6-387.pdf.txt1756-0500-6-387.pdf.txtExtracted texttext/plain34565https://repositorio.ufba.br/bitstream/ri/15255/3/1756-0500-6-387.pdf.txt7a8fea1a0af196c9050ee63c2da6aba8MD53ri/152552022-08-08 13:17:26.777oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:26Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
dc.title.alternative.pt_BR.fl_str_mv BMC Research Notes
title Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
spellingShingle Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
Almeida, Neogélia Pereira
Crohn’s disease
Polymorphism
TGFB1
IL10
title_short Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
title_full Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
title_fullStr Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
title_full_unstemmed Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
title_sort Polymorphisms of the cytokine genes TGFB1 and IL10 in a mixed-race population with Crohn’s disease
author Almeida, Neogélia Pereira
author_facet Almeida, Neogélia Pereira
Santana, Genoile Oliveira
Almeida, Tamara Celi
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Lemaire, Denise Carneiro
Cardeal, Mauricio
Lyra, André Castro
author_role author
author2 Santana, Genoile Oliveira
Almeida, Tamara Celi
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Lemaire, Denise Carneiro
Cardeal, Mauricio
Lyra, André Castro
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Almeida, Neogélia Pereira
Santana, Genoile Oliveira
Almeida, Tamara Celi
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Lemaire, Denise Carneiro
Cardeal, Mauricio
Lyra, André Castro
Almeida, Neogélia Pereira
Santana, Genoile Oliveira
Almeida, Tamara Celi
Bendicho, Maria Teresita Del Niño Jesus Fernandez
Lemaire, Denise Carneiro
Cardeal, Mauricio
Lyra, André Castro
dc.subject.por.fl_str_mv Crohn’s disease
Polymorphism
TGFB1
IL10
topic Crohn’s disease
Polymorphism
TGFB1
IL10
description p. 1-7
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-07-22T13:46:26Z
dc.date.available.fl_str_mv 2014-07-22T13:46:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15255
dc.identifier.issn.none.fl_str_mv 1756-0500
dc.identifier.number.pt_BR.fl_str_mv v. 6, n. 1
identifier_str_mv 1756-0500
v. 6, n. 1
url http://repositorio.ufba.br/ri/handle/ri/15255
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1186/1756-0500-6-387
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