C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2004 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/2983 |
Resumo: | p. 529-533 |
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Couto, Fábio DavidAdorno, Elisângela VitóriaMenezes, Joelma FigueiredoMoura Neto, José PereiraRêgo, Marco Antônio VasconcelosReis, Mitermayer Galvão dosGonçalves, Marilda SouzaCouto, Fábio DavidAdorno, Elisângela VitóriaMenezes, Joelma FigueiredoMoura Neto, José PereiraRêgo, Marco Antônio VasconcelosReis, Mitermayer Galvão dosGonçalves, Marilda Souza2011-09-29T14:12:47Z2011-09-29T14:12:47Z20040102-311Xhttp://www.repositorio.ufba.br/ri/handle/ri/298320(2)p. 529-533The C677T polymorphism in the methylenetet ra h y d rofolate reductase gene (MTHFR) is associated with an increase in total homocysteine serum levels (tHcy), described as a risk factor for cardiovascular disease. Eight hundred fort y - t h ree neonates from two different maternity h o spitals , one public and another priva t e , in Salva d o r, Ba h i a , Brazil were screened for this polymorphism by PCR and RFLP. The T-allele frequency in the total sample was 0.23, and the p re valence rates of heterozygous and homoz ygous carriers were 36.2% and 5.3%, re s p e c t i ve l y. The T-allele frequency differed and the T/T g e n otype was more pre valent at the private maternity hospital. The hemoglobin (Hb) profile was investigated by HPLC in 763 new b o r n s . The frequency of variant Hb was higher at the public than at the private maternity hospital. The association of the C677T polymorphism and the Hb profile was investigated in 683 newborns , showing are latively high frequency of variant Hbs and the T allele. These data could provide an important basis for further studies focusing on potential risks of vaso - occlusive events in these individuals.Submitted by Ana Valéria de Jesus Moura (anavaleria_131@hotmail.com) on 2011-09-29T14:12:47Z No. of bitstreams: 1 21 (1).pdf: 119098 bytes, checksum: 1f65cbe67346de87babf4acf946593f8 (MD5)Made available in DSpace on 2011-09-29T14:12:47Z (GMT). No. of bitstreams: 1 21 (1).pdf: 119098 bytes, checksum: 1f65cbe67346de87babf4acf946593f8 (MD5) Previous issue date: 2004Newborns InfantPolymorphismHemoglobin opathiesRecém - nascidosPolimorfismoHemoglobinopatiasC677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, BrazilCadernos de Saúde Públicainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINAL21 (1).pdf21 (1).pdfapplication/pdf119098https://repositorio.ufba.br/bitstream/ri/2983/1/21%20%281%29.pdf1f65cbe67346de87babf4acf946593f8MD51LICENSElicense.txtlicense.txttext/plain1918https://repositorio.ufba.br/bitstream/ri/2983/2/license.txtdc4e422d6a4ef63d31c2601e626b4eebMD52TEXT21 (1).pdf.txt21 (1).pdf.txtExtracted texttext/plain22832https://repositorio.ufba.br/bitstream/ri/2983/3/21%20%281%29.pdf.txt1285b9e0ed18cf42f00b1b56433bb52fMD53ri/29832022-07-05 14:03:13.966oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| dc.title.alternative.pt_BR.fl_str_mv |
Cadernos de Saúde Pública |
| title |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| spellingShingle |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil Couto, Fábio David Newborns Infant Polymorphism Hemoglobin opathies Recém - nascidos Polimorfismo Hemoglobinopatias |
| title_short |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| title_full |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| title_fullStr |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| title_full_unstemmed |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| title_sort |
C677T polymorphism of the MTHFR gene and variant hemoglobins: a study in newborn s f rom Salvador, Bahia, Brazil |
| author |
Couto, Fábio David |
| author_facet |
Couto, Fábio David Adorno, Elisângela Vitória Menezes, Joelma Figueiredo Moura Neto, José Pereira Rêgo, Marco Antônio Vasconcelos Reis, Mitermayer Galvão dos Gonçalves, Marilda Souza |
| author_role |
author |
| author2 |
Adorno, Elisângela Vitória Menezes, Joelma Figueiredo Moura Neto, José Pereira Rêgo, Marco Antônio Vasconcelos Reis, Mitermayer Galvão dos Gonçalves, Marilda Souza |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Couto, Fábio David Adorno, Elisângela Vitória Menezes, Joelma Figueiredo Moura Neto, José Pereira Rêgo, Marco Antônio Vasconcelos Reis, Mitermayer Galvão dos Gonçalves, Marilda Souza Couto, Fábio David Adorno, Elisângela Vitória Menezes, Joelma Figueiredo Moura Neto, José Pereira Rêgo, Marco Antônio Vasconcelos Reis, Mitermayer Galvão dos Gonçalves, Marilda Souza |
| dc.subject.por.fl_str_mv |
Newborns Infant Polymorphism Hemoglobin opathies Recém - nascidos Polimorfismo Hemoglobinopatias |
| topic |
Newborns Infant Polymorphism Hemoglobin opathies Recém - nascidos Polimorfismo Hemoglobinopatias |
| description |
p. 529-533 |
| publishDate |
2004 |
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2004 |
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2011-09-29T14:12:47Z |
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2011-09-29T14:12:47Z |
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