Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/6611 |
Resumo: | p.375-381 |
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Silva, Marcelo Gomes daCastro, Aldemar AraújoRamos, Eduardo Antônio GonçalvesPeixoto, EdiriomarMiranda Júnior, FaustoPitta, Guilherme de Benjamin BrandãoCosta, Regina de Faria BittencourtJuliano, YaraSilva, Marcelo Gomes daCastro, Aldemar AraújoRamos, Eduardo Antônio GonçalvesPeixoto, EdiriomarMiranda Júnior, FaustoPitta, Guilherme de Benjamin BrandãoCosta, Regina de Faria BittencourtJuliano, Yara2012-08-22T12:50:47Z2012-08-22T12:50:47Z2005-091678-2674http://www.repositorio.ufba.br/ri/handle/ri/6611v. 20, n. 5p.375-381PURPOSE: To evaluate the protective action of alpha-tocopherol in ischemia/reperfusion injuries of pelvic member of rats. METHODS: Thirty adult male rats of the Wistar strain were randomized into three experimental groups of 10: Group I – control group with no ischemia or reperfusion. Groups II and III – four hours of ischemia and of hours of reperfusion by means of clamping of the infrarenal aorta. The animals of Group II were treated with saline and those of Group III were treated with i.v. alpha-tocopherol (50 mg/kg). Parameters studied were biopsies of the soleus muscle, dosing of creatine phosphokinase, lactate dehydrogenase, potassium, calcium and arterial blood gasometry. RESULTS: The results of biopsies of the soleus muscles studied by optical microscopy, were not significant in terms of presence of edema among the three groups studied. Variables inflammation and necrosis were not observed, therefore cannot be statistically analyzed. As to dosing of calcium and lactate dehydrogenase, the pH, pO2 and pCO2 values were not significant for all groups studied. We observed that the levels of potassium (Group II > Group I, Fcalculated = 5.84; Fcritical = 3.33), creatine phosphokinase (Group II > Groups I and III, Hcalculated = 13.92; Hcritical = 5.99) and bicarbonate (Groups I and III > Group II, Hcalculated = 11.98; Hcritical = 5.99) presented significant results among groups. CONCLUSION: From the serum biochemical perspective, the treatment with alpha-tocopherol has attenuated the metabolic injuries in the ischemia/reperfusion syndrome in this experimental model.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-08-22T12:50:47Z No. of bitstreams: 1 Silva, Marcelo Gomes da.pdf: 164078 bytes, checksum: 0acf25cbfb6ddaf10c6d927679aaa837 (MD5)Made available in DSpace on 2012-08-22T12:50:47Z (GMT). No. of bitstreams: 1 Silva, Marcelo Gomes da.pdf: 164078 bytes, checksum: 0acf25cbfb6ddaf10c6d927679aaa837 (MD5) Previous issue date: 2005-09São PauloActa Cirúrgica Brasileira/SOBRADPEChttp://dx.doi.org/10.1590/S0102-86502005000500007reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAIschemiaReperfusionAlpha-TocopherolRatsHistological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of ratsActa Cirurgica Brasileirainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALSilva, Marcelo Gomes da.pdfSilva, Marcelo Gomes da.pdfapplication/pdf164078https://repositorio.ufba.br/bitstream/ri/6611/1/Silva%2c%20Marcelo%20Gomes%20da.pdf0acf25cbfb6ddaf10c6d927679aaa837MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6611/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTSilva, Marcelo Gomes da.pdf.txtSilva, Marcelo Gomes da.pdf.txtExtracted texttext/plain30966https://repositorio.ufba.br/bitstream/ri/6611/3/Silva%2c%20Marcelo%20Gomes%20da.pdf.txt3fb81bfc276023b9f5700c3434606feeMD53ri/66112022-07-05 14:03:20.337oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| dc.title.alternative.pt_BR.fl_str_mv |
Acta Cirurgica Brasileira |
| title |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| spellingShingle |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats Silva, Marcelo Gomes da Ischemia Reperfusion Alpha-Tocopherol Rats |
| title_short |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| title_full |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| title_fullStr |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| title_full_unstemmed |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| title_sort |
Histological and biochemical serum effects of alpha-tocopherol on ischemia/ reperfusion-related injuries induced in the pelvic limb of rats |
| author |
Silva, Marcelo Gomes da |
| author_facet |
Silva, Marcelo Gomes da Castro, Aldemar Araújo Ramos, Eduardo Antônio Gonçalves Peixoto, Ediriomar Miranda Júnior, Fausto Pitta, Guilherme de Benjamin Brandão Costa, Regina de Faria Bittencourt Juliano, Yara |
| author_role |
author |
| author2 |
Castro, Aldemar Araújo Ramos, Eduardo Antônio Gonçalves Peixoto, Ediriomar Miranda Júnior, Fausto Pitta, Guilherme de Benjamin Brandão Costa, Regina de Faria Bittencourt Juliano, Yara |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, Marcelo Gomes da Castro, Aldemar Araújo Ramos, Eduardo Antônio Gonçalves Peixoto, Ediriomar Miranda Júnior, Fausto Pitta, Guilherme de Benjamin Brandão Costa, Regina de Faria Bittencourt Juliano, Yara Silva, Marcelo Gomes da Castro, Aldemar Araújo Ramos, Eduardo Antônio Gonçalves Peixoto, Ediriomar Miranda Júnior, Fausto Pitta, Guilherme de Benjamin Brandão Costa, Regina de Faria Bittencourt Juliano, Yara |
| dc.subject.por.fl_str_mv |
Ischemia Reperfusion Alpha-Tocopherol Rats |
| topic |
Ischemia Reperfusion Alpha-Tocopherol Rats |
| description |
p.375-381 |
| publishDate |
2005 |
| dc.date.issued.fl_str_mv |
2005-09 |
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2012-08-22T12:50:47Z |
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2012-08-22T12:50:47Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://www.repositorio.ufba.br/ri/handle/ri/6611 |
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1678-2674 |
| dc.identifier.number.pt_BR.fl_str_mv |
v. 20, n. 5 |
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1678-2674 v. 20, n. 5 |
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http://www.repositorio.ufba.br/ri/handle/ri/6611 |
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Acta Cirúrgica Brasileira/SOBRADPEC |
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Acta Cirúrgica Brasileira/SOBRADPEC |
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http://dx.doi.org/10.1590/S0102-86502005000500007 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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