Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers

Detalhes bibliográficos
Autor(a) principal: Cotrim, Helma Pinchemel
Data de Publicação: 1999
Outros Autores: Andrade, Zilton de Araújo, Paraná, Raymundo, Portugal, Marcelo, Lyra, Luiz Guilherme Costa, Freitas, Luiz A. R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7510
Resumo: Texto complexo: acesso restriro, p. 299-304
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spelling Cotrim, Helma PinchemelAndrade, Zilton de AraújoParaná, RaymundoPortugal, MarceloLyra, Luiz Guilherme CostaFreitas, Luiz A. R.Cotrim, Helma PinchemelAndrade, Zilton de AraújoParaná, RaymundoPortugal, MarceloLyra, Luiz Guilherme CostaFreitas, Luiz A. R.2012-12-13T18:03:39Z19991478-3223http://www.repositorio.ufba.br/ri/handle/ri/7510v. 19, n. 4Texto complexo: acesso restriro, p. 299-304Aims: Occupational/environmental exposure to hepatotoxins has recently been implicated in nonalcoholic steatohepatitis (NASH). The aims of this study were to determine the presence and frequency of NASH in a large group of workers chronically exposed to several volatile petrochemical products in an industrial area in north-east Brazil and to observe its course in workers removed from the work environment. Methods: 1500 asymptomatic workers were screened with standard liver blood tests during 1994–5. Those with elevated transaminases (>3× normal) on 3 occasions were evaluated further both clinically and with serum HBsAg, anti-HCV, ferritin, lipids and autoantibody determination. Patients with either no etiological diagnosis, positive HBsAg/anti-HCV serology and/or excess alcohol intake underwent liver biopsy. Those with obesity, diabetes or an isolated abnormal GGT were excluded. Of workers diagnosed as having NASH (compatible histology and no excess alcohol intake), a proportion were removed from the work environment and evaluated monthly with liver blood tests and a repeat liver biopsy 8–14 months later. Results: 112 workers had abnormal transaminases and 32 fulfilled the criteria for liver biopsy. 20 of these were classified as NASH, the remainder had viral hepatitis (n=6), alcoholic liver disease (n=5) or portal vein thrombosis (n=1). In all of the 10/20 who were removed from the work environment, their aminotransferases and GGT gradually decreased and their histology improved. Conclusions: These results demonstrate that NASH can occur following chronic exposure to volatile petrochemical substances in the workplace. Exposed workers should be regularly screened for the presence of liver damage and ideally removed from the work environment where possible.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-12-13T18:03:38Z No. of bitstreams: 1 Helma.pdf: 1488046 bytes, checksum: 6c5b0780faf90818537f46c953dd8794 (MD5)Made available in DSpace on 2012-12-13T18:03:39Z (GMT). No. of bitstreams: 1 Helma.pdf: 1488046 bytes, checksum: 6c5b0780faf90818537f46c953dd8794 (MD5) Previous issue date: 1999-08Nonalcoholic steatohepatitisHepatotoxicityToxic liver injuryEnvironmental hepatotoxinsNonalcoholic steatohepatitis: a toxic liver disease in industrial workersLiver Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01engreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALHelma.pdfHelma.pdfapplication/pdf1488046https://repositorio.ufba.br/bitstream/ri/7510/1/Helma.pdf6c5b0780faf90818537f46c953dd8794MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7510/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTHelma.pdf.txtHelma.pdf.txtExtracted texttext/plain18808https://repositorio.ufba.br/bitstream/ri/7510/3/Helma.pdf.txt23d6e5ef1435c2b462dd440f903e56deMD53ri/75102022-10-10 14:25:41.695oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-10T17:25:41Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
dc.title.alternative.pt_BR.fl_str_mv Liver International
title Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
spellingShingle Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
Cotrim, Helma Pinchemel
Nonalcoholic steatohepatitis
Hepatotoxicity
Toxic liver injury
Environmental hepatotoxins
title_short Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
title_full Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
title_fullStr Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
title_full_unstemmed Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
title_sort Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers
author Cotrim, Helma Pinchemel
author_facet Cotrim, Helma Pinchemel
Andrade, Zilton de Araújo
Paraná, Raymundo
Portugal, Marcelo
Lyra, Luiz Guilherme Costa
Freitas, Luiz A. R.
author_role author
author2 Andrade, Zilton de Araújo
Paraná, Raymundo
Portugal, Marcelo
Lyra, Luiz Guilherme Costa
Freitas, Luiz A. R.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cotrim, Helma Pinchemel
Andrade, Zilton de Araújo
Paraná, Raymundo
Portugal, Marcelo
Lyra, Luiz Guilherme Costa
Freitas, Luiz A. R.
Cotrim, Helma Pinchemel
Andrade, Zilton de Araújo
Paraná, Raymundo
Portugal, Marcelo
Lyra, Luiz Guilherme Costa
Freitas, Luiz A. R.
dc.subject.por.fl_str_mv Nonalcoholic steatohepatitis
Hepatotoxicity
Toxic liver injury
Environmental hepatotoxins
topic Nonalcoholic steatohepatitis
Hepatotoxicity
Toxic liver injury
Environmental hepatotoxins
description Texto complexo: acesso restriro, p. 299-304
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2012-12-13T18:03:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7510
dc.identifier.issn.none.fl_str_mv 1478-3223
dc.identifier.number.pt_BR.fl_str_mv v. 19, n. 4
identifier_str_mv 1478-3223
v. 19, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/7510
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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