Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17669 |
Resumo: | p. 149-162 |
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Oliveira, João Paulo Maia deTrzesniak, ClarissaOliveira, Irismar R.Baker, Glen B.Kempton, Matthew J.Rezende, Tatiana M. N. deIego, SandroDursun, Serdar M.Sousa, João Paulo Machado deHallak, Jaime E. C.Oliveira, João Paulo Maia deTrzesniak, ClarissaOliveira, Irismar R.Baker, Glen B.Kempton, Matthew J.Rezende, Tatiana M. N. deIego, SandroDursun, Serdar M.Sousa, João Paulo Machado deHallak, Jaime E. C.2015-05-11T15:52:56Z20121516-4446http://repositorio.ufba.br/ri/handle/ri/17669v. 34, n. 2p. 149-162For the last 40 years, schizophrenia has been considered to be the result primarily of a dysfunction in brain dopaminergic pathways. In this review, it is described and discussed findings concerning nitric oxide-mediated neurotransmission in schizophrenia. Studies were searched in PubMed, SciELO, and LILACS using the terms schizophrenia and nitric oxide plasma levels or nitric oxide serum levels, with no time limit. The reference lists of selected articles were also hand-searched for additional articles. From 15 potential reports, 10 were eligible to be included in the review and meta-analysis. These studies included a total of 505 patients with schizophrenia and 339 healthy volunteers. No significant difference was found between patients and healthy controls regarding total nitrite plasma/serum levels (effect size g = 0.285, 95%CI = -0.205 to 0.774, p = 0.254). However, when studies with patients under antipsychotic treatment were examined separately, there was a significant difference between patients and healthy volunteers (effect size g = 0.663, 95%CI = 0.365 to 0.961, p < 0.001), showing that patients under treatment have higher levels of plasma/serum nitric oxide than controls. These results suggest that antipsychotics increase nitric oxide plasma/serum levels and that the nitrergic pathway would be a fertile target for the development of new treatments for patients with schizophrenia.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-20T17:07:53Z No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-05-11T15:52:56Z (GMT) No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5)Made available in DSpace on 2015-05-11T15:52:56Z (GMT). No. of bitstreams: 1 Sandro Iego.pdf: 1138266 bytes, checksum: 5a67ec6afc408f26b777706afbcb100d (MD5) Previous issue date: 2012http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.rbp.2012.07.001reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBANitric OxideSchizophreniaPsychosisPlasma levelsSerum levelsMeta-analysisSystematic reviewNitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-AnalysisRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01Brasilinfo:eu-repo/semantics/openAccessporORIGINALSandro Iego.pdfSandro Iego.pdfapplication/pdf1138266https://repositorio.ufba.br/bitstream/ri/17669/1/Sandro%20Iego.pdf5a67ec6afc408f26b777706afbcb100dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17669/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTSandro Iego.pdf.txtSandro Iego.pdf.txtExtracted texttext/plain57541https://repositorio.ufba.br/bitstream/ri/17669/3/Sandro%20Iego.pdf.txt7cfffad66959d41e7a4d568726e7c5e3MD53ri/176692022-07-05 14:05:18.567oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| dc.title.alternative.pt_BR.fl_str_mv |
Revista Brasileira de Psiquiatria |
| title |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| spellingShingle |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis Oliveira, João Paulo Maia de Nitric Oxide Schizophrenia Psychosis Plasma levels Serum levels Meta-analysis Systematic review |
| title_short |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| title_full |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| title_fullStr |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| title_full_unstemmed |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| title_sort |
Nitric Oxide Plasma/Serum Levels In Patients With Schizophrenia: A Systematic Review And Meta-Analysis |
| author |
Oliveira, João Paulo Maia de |
| author_facet |
Oliveira, João Paulo Maia de Trzesniak, Clarissa Oliveira, Irismar R. Baker, Glen B. Kempton, Matthew J. Rezende, Tatiana M. N. de Iego, Sandro Dursun, Serdar M. Sousa, João Paulo Machado de Hallak, Jaime E. C. |
| author_role |
author |
| author2 |
Trzesniak, Clarissa Oliveira, Irismar R. Baker, Glen B. Kempton, Matthew J. Rezende, Tatiana M. N. de Iego, Sandro Dursun, Serdar M. Sousa, João Paulo Machado de Hallak, Jaime E. C. |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, João Paulo Maia de Trzesniak, Clarissa Oliveira, Irismar R. Baker, Glen B. Kempton, Matthew J. Rezende, Tatiana M. N. de Iego, Sandro Dursun, Serdar M. Sousa, João Paulo Machado de Hallak, Jaime E. C. Oliveira, João Paulo Maia de Trzesniak, Clarissa Oliveira, Irismar R. Baker, Glen B. Kempton, Matthew J. Rezende, Tatiana M. N. de Iego, Sandro Dursun, Serdar M. Sousa, João Paulo Machado de Hallak, Jaime E. C. |
| dc.subject.por.fl_str_mv |
Nitric Oxide Schizophrenia Psychosis Plasma levels Serum levels Meta-analysis Systematic review |
| topic |
Nitric Oxide Schizophrenia Psychosis Plasma levels Serum levels Meta-analysis Systematic review |
| description |
p. 149-162 |
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2012 |
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2012 |
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2015-05-11T15:52:56Z |
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1516-4446 |
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v. 34, n. 2 |
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1516-4446 v. 34, n. 2 |
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