Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)

Detalhes bibliográficos
Autor(a) principal: Geris, Regina
Data de Publicação: 2008
Outros Autores: Silva, Ionizete Garcia da, Silva, Heloísa Helena Garcia da, Barison, Andersson, Rodrigues-Filho, Edson, Ferreira, Antônio Gilberto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/2188
Resumo: p.25-28,v.50,n.1,São Paulo Jan./Feb.2008
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spelling Geris, ReginaSilva, Ionizete Garcia daSilva, Heloísa Helena Garcia daBarison, AnderssonRodrigues-Filho, EdsonFerreira, Antônio GilbertoGeris, ReginaSilva, Ionizete Garcia daSilva, Heloísa Helena Garcia daBarison, AnderssonRodrigues-Filho, EdsonFerreira, Antônio Gilberto2011-08-13T02:18:46Z2011-08-13T02:18:46Z20080036-4665http://www.repositorio.ufba.br/ri/handle/ri/218850(1):25-28p.25-28,v.50,n.1,São Paulo Jan./Feb.2008The objective of this study was to evaluate the larvicidal activity of diterpenoids obtained from the oil-resin of Copaifera reticulata against Aedes aegypti larvae, the principal vector of dengue and urban yellow fever. Four diterpenes were obtained from oil-resin extraction with organic solvents and subsequent chromatographic and spectroscopic procedures allowed to isolation and identification of these compounds as 3-b-acetoxylabdan-8(17)-13-dien-15-oic acid (1), alepterolic acid (2), 3-b-hidroxylabdan-8(17)-en-15-oic acid (3), and ent-agatic acid (4). Each compound was previously dissolved in dimethylsulphoxide, and distilled water was added to obtain the desired concentrations. Twenty larvae of third instars were placed into plastic beckers, containing the solution test (25 mL), in a five repetitions scheme, and their mortality, indicated by torpor and darkening of the cephalic capsule, was recorded after 48h. Probit analyses were used to determine lethal concentrations (LC50 and LC90) and their respective 95% confidence intervals. This study showed that only diterpenoids 1 and 2 exhibited larvicidal properties with LC50 of 0.8 ppm and 87.3 ppm, respectively, revealing the former as the most toxic compound against third instars of Ae. aegypti. Therefore, this compound seems to be an interesting source for new metabolite to be exploited.Submitted by Rigaud Andréa (andrearigaud16@yahoo.com.br) on 2011-08-13T02:18:46Z No. of bitstreams: 1 a06v50n1.pdf: 63452 bytes, checksum: ef60f20e0824a8f8a8f458256dfa6946 (MD5)Made available in DSpace on 2011-08-13T02:18:46Z (GMT). No. of bitstreams: 1 a06v50n1.pdf: 63452 bytes, checksum: ef60f20e0824a8f8a8f458256dfa6946 (MD5) Previous issue date: 2008São PauloCopaifera reticulataent-Labdane DiterpenoidsLarvicidal activityAedes aegyptiDiterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALa06v50n1.pdfa06v50n1.pdfapplication/pdf63452https://repositorio.ufba.br/bitstream/ri/2188/1/a06v50n1.pdfef60f20e0824a8f8a8f458256dfa6946MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/2188/2/license.txt9109e80624dddd4efdd11cf382e0043dMD52TEXTa06v50n1.pdf.txta06v50n1.pdf.txtExtracted texttext/plain19081https://repositorio.ufba.br/bitstream/ri/2188/3/a06v50n1.pdf.txta96d54e0bbf43f114efdfe118596f3c4MD53ri/21882022-07-05 14:03:09.108oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:09Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
dc.title.alternative.pt_BR.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo
title Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
spellingShingle Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
Geris, Regina
Copaifera reticulata
ent-Labdane Diterpenoids
Larvicidal activity
Aedes aegypti
title_short Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
title_full Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
title_fullStr Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
title_full_unstemmed Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
title_sort Diterpenoids from Copaifera reticulata Ducke with larvicidal activity against Aedes aegypti (L.) (Diptera, Culicidae)
author Geris, Regina
author_facet Geris, Regina
Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
author_role author
author2 Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Geris, Regina
Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
Geris, Regina
Silva, Ionizete Garcia da
Silva, Heloísa Helena Garcia da
Barison, Andersson
Rodrigues-Filho, Edson
Ferreira, Antônio Gilberto
dc.subject.por.fl_str_mv Copaifera reticulata
ent-Labdane Diterpenoids
Larvicidal activity
Aedes aegypti
topic Copaifera reticulata
ent-Labdane Diterpenoids
Larvicidal activity
Aedes aegypti
description p.25-28,v.50,n.1,São Paulo Jan./Feb.2008
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2011-08-13T02:18:46Z
dc.date.available.fl_str_mv 2011-08-13T02:18:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/2188
dc.identifier.issn.none.fl_str_mv 0036-4665
dc.identifier.number.pt_BR.fl_str_mv 50(1):25-28
identifier_str_mv 0036-4665
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url http://www.repositorio.ufba.br/ri/handle/ri/2188
dc.language.iso.fl_str_mv eng
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collection Repositório Institucional da UFBA
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