Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16290 |
Resumo: | Texto completo: acesso restrito. p. 1236-1243 |
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Teixeira, Márcia Cristina AquinoSilva, Virgínia M. G.Larangeira, Daniela FariasOliveira, Pablo R. S.Sampaio, Romina B.Suzart, PaulaNihei, Jorge S.Mengel, José O.Santos, Washington Luis Conrado dosCarvalho, Lain Carlos Pontes deTeixeira, Márcia Cristina AquinoSilva, Virgínia M. G.Larangeira, Daniela FariasOliveira, Pablo R. S.Sampaio, Romina B.Suzart, PaulaNihei, Jorge S.Mengel, José O.Santos, Washington Luis Conrado dosCarvalho, Lain Carlos Pontes de2014-10-03T19:09:10Z20110019-9567http://repositorio.ufba.br/ri/handle/ri/16290v. 79, n. 3Texto completo: acesso restrito. p. 1236-1243Most inbred strains of mice, like the BALB/c strain, are susceptible to Leishmania amazonensis infections and resistant to Leishmania braziliensis infections. This parasite-related difference could result from the activity of an L. amazonensis-specific virulence factor. In agreement with this hypothesis, it is shown here that the intravenous injection of BALB/c mice with L. amazonensis amastigote extract (LaE) but not the L. braziliensis extract confers susceptibility to L. braziliensis infection. This effect was associated with high circulating levels of IgG1 anti-L. amazonensis antibodies and with an increase in interleukin-4 (IL-4) production and a decrease in gamma interferon production by draining lymph node cells. Moreover, the effect was absent in IL-4-knockout mice. The biological activity in the LaE was not mediated by amphiphilic molecules and was inhibited by pretreatment of the extract with irreversible serine protease inhibitors. These findings indicate that the LaE contains a virulence-related factor that (i) enhances the Leishmania infection by promoting Th2-type immune responses, (ii) is not one of the immunomodulatory Leishmania molecules described so far, and (iii) is either a serine protease or has an effect that depends on that protease activity. In addition to being Leishmania species specific, the infection-enhancing activity was also shown to depend on the host genetic makeup, as LaE injections did not affect the susceptibility of C57BL/6 mice to L. braziliensis infection. The identification of Leishmania molecules with infection-enhancing activity could be important for the development of a vaccine, since the up- or downmodulation of the immune response against a virulence factor could well contribute to controlling the infection.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-08T11:19:54Z No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-10-03T19:09:09Z (GMT) No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5)Made available in DSpace on 2014-10-03T19:09:10Z (GMT). No. of bitstreams: 1 Márcia C. A. Teixeira.pdf: 845488 bytes, checksum: 446d66a494b91995feed1ab092cc951e (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1128/IAI.00309-10reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEnhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic BackgroundsInfection and Immunityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALMárcia C. A. Teixeira.pdfMárcia C. A. 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dc.title.pt_BR.fl_str_mv |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
dc.title.alternative.pt_BR.fl_str_mv |
Infection and Immunity |
title |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
spellingShingle |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds Teixeira, Márcia Cristina Aquino |
title_short |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
title_full |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
title_fullStr |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
title_full_unstemmed |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
title_sort |
Enhancement of Experimental Cutaneous Leishmaniasis by Leishmania Molecules Is Dependent on Interleukin-4, Serine Protease/Esterase Activity, and Parasite and Host Genetic Backgrounds |
author |
Teixeira, Márcia Cristina Aquino |
author_facet |
Teixeira, Márcia Cristina Aquino Silva, Virgínia M. G. Larangeira, Daniela Farias Oliveira, Pablo R. S. Sampaio, Romina B. Suzart, Paula Nihei, Jorge S. Mengel, José O. Santos, Washington Luis Conrado dos Carvalho, Lain Carlos Pontes de |
author_role |
author |
author2 |
Silva, Virgínia M. G. Larangeira, Daniela Farias Oliveira, Pablo R. S. Sampaio, Romina B. Suzart, Paula Nihei, Jorge S. Mengel, José O. Santos, Washington Luis Conrado dos Carvalho, Lain Carlos Pontes de |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Teixeira, Márcia Cristina Aquino Silva, Virgínia M. G. Larangeira, Daniela Farias Oliveira, Pablo R. S. Sampaio, Romina B. Suzart, Paula Nihei, Jorge S. Mengel, José O. Santos, Washington Luis Conrado dos Carvalho, Lain Carlos Pontes de Teixeira, Márcia Cristina Aquino Silva, Virgínia M. G. Larangeira, Daniela Farias Oliveira, Pablo R. S. Sampaio, Romina B. Suzart, Paula Nihei, Jorge S. Mengel, José O. Santos, Washington Luis Conrado dos Carvalho, Lain Carlos Pontes de |
description |
Texto completo: acesso restrito. p. 1236-1243 |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011 |
dc.date.accessioned.fl_str_mv |
2014-10-03T19:09:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/16290 |
dc.identifier.issn.none.fl_str_mv |
0019-9567 |
dc.identifier.number.pt_BR.fl_str_mv |
v. 79, n. 3 |
identifier_str_mv |
0019-9567 v. 79, n. 3 |
url |
http://repositorio.ufba.br/ri/handle/ri/16290 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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http://dx.doi.org/ 10.1128/IAI.00309-10 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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