Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/2839 |
Resumo: | Texto integral disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070800/pdf/main.pdf |
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Figueiredo, Camila A.Alcântara-Neves, Neuza MariaAmorim, Leila Denise Alves FerreiraSilva, Nivea B.Carvalho, Lain Carlos Pontes deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio LimaFigueiredo, Camila A.Alcântara-Neves, Neuza MariaAmorim, Leila Denise Alves FerreiraSilva, Nivea B.Carvalho, Lain Carlos Pontes deCooper, Philip J.Rodrigues, Laura C.Barreto, Mauricio Lima2011-09-23T14:14:37Z2011-09-23T14:14:37Z20111090-2341http://www.repositorio.ufba.br/ri/handle/ri/2839v.139, n.1, p.57-64, 2011.Texto integral disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070800/pdf/main.pdfAllergic and other immune-mediated diseases are complex disease states determined by interplay between host genetics and environmental factors. Environmental changes such as fewer infections and reduced exposure to microbial products have been suggested to have led to insufficient regulation of Th1 and Th2 immune responses, causing an increased incidence of inflammatory diseases. The objective of the present study was to investigate the effect of poor living environmental conditions on mitogen-induced production of cytokines (Th1 and Th2) by peripheral blood leukocytes in children living in urban Brazil and investigate the role of IL-10 in modifying this effect. Our data showed that the proportion of children producing Th1 and Th2 cytokines was lower among those with poor living conditions and that this finding was stronger in children producing IL-10. These results provide a possible biologic explanation for the temporal trends of increasing risk of inflammatory diseases observed in populations living in affluent countriesSubmitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2011-09-23T14:14:37Z No. of bitstreams: 1 Evidence for a modulatory effect of IL.doc: 25600 bytes, checksum: b1275fab4c2ed0c40c6428900bf4b599 (MD5)Made available in DSpace on 2011-09-23T14:14:37Z (GMT). No. of bitstreams: 1 Evidence for a modulatory effect of IL.doc: 25600 bytes, checksum: b1275fab4c2ed0c40c6428900bf4b599 (MD5) Previous issue date: 2011OrlandoEnvironmentSewage systemStreet pavingImmune regulationEvidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environmentClin Immunolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALEvidence for a modulatory effect of IL.docEvidence for a modulatory effect of IL.docapplication/msword25600https://repositorio.ufba.br/bitstream/ri/2839/1/Evidence%20for%20a%20modulatory%20effect%20of%20IL.docb1275fab4c2ed0c40c6428900bf4b599MD51LICENSElicense.txtlicense.txttext/plain1907https://repositorio.ufba.br/bitstream/ri/2839/2/license.txt47a4c5abb8af34bb7b1e6997f948ac86MD52TEXTEvidence for a modulatory effect of IL.doc.txtEvidence for a modulatory effect of IL.doc.txtExtracted texttext/plain1350https://repositorio.ufba.br/bitstream/ri/2839/3/Evidence%20for%20a%20modulatory%20effect%20of%20IL.doc.txt255230cd35b42c7f74ef10b123a4134cMD53ri/28392022-07-05 14:03:51.753oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| dc.title.alternative.pt_BR.fl_str_mv |
Clin Immunol |
| title |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| spellingShingle |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment Figueiredo, Camila A. Environment Sewage system Street paving Immune regulation |
| title_short |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| title_full |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| title_fullStr |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| title_full_unstemmed |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| title_sort |
Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment |
| author |
Figueiredo, Camila A. |
| author_facet |
Figueiredo, Camila A. Alcântara-Neves, Neuza Maria Amorim, Leila Denise Alves Ferreira Silva, Nivea B. Carvalho, Lain Carlos Pontes de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
| author_role |
author |
| author2 |
Alcântara-Neves, Neuza Maria Amorim, Leila Denise Alves Ferreira Silva, Nivea B. Carvalho, Lain Carlos Pontes de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Figueiredo, Camila A. Alcântara-Neves, Neuza Maria Amorim, Leila Denise Alves Ferreira Silva, Nivea B. Carvalho, Lain Carlos Pontes de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima Figueiredo, Camila A. Alcântara-Neves, Neuza Maria Amorim, Leila Denise Alves Ferreira Silva, Nivea B. Carvalho, Lain Carlos Pontes de Cooper, Philip J. Rodrigues, Laura C. Barreto, Mauricio Lima |
| dc.subject.por.fl_str_mv |
Environment Sewage system Street paving Immune regulation |
| topic |
Environment Sewage system Street paving Immune regulation |
| description |
Texto integral disponível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070800/pdf/main.pdf |
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2011 |
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2011-09-23T14:14:37Z |
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2011-09-23T14:14:37Z |
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2011 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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1090-2341 |
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v.139, n.1, p.57-64, 2011. |
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1090-2341 v.139, n.1, p.57-64, 2011. |
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