Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain

Detalhes bibliográficos
Autor(a) principal: Maia Junior, Hugo
Data de Publicação: 2012
Outros Autores: Haddad, Clarice, Pinheiro, Nathanael, Casoy, Julio
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15049
Resumo: Texto completo: acesso restrito. p. 543-549
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spelling Maia Junior, HugoHaddad, ClaricePinheiro, NathanaelCasoy, JulioMaia Junior, HugoHaddad, ClaricePinheiro, NathanaelCasoy, Julio2014-06-04T16:40:03Z20121179-1411http://repositorio.ufba.br/ri/handle/ri/15049v. 4, n. 1Texto completo: acesso restrito. p. 543-549Background: The effect of resveratrol on the management of endometriosis-related pain was investigated in 12 patients who failed to obtain pain relief during use of an oral contraceptive containing drospirenone + ethinylestradiol. Methods and results: The addition of 30 mg of resveratrol to the contraceptive regimen resulted in a significant reduction in pain scores, with 82% of patients reporting complete resolution of dysmenorrhea and pelvic pain after 2 months of use. In a separate experiment, aromatase and cyclo-oxygenase-2 expression were investigated in the endometrial tissue of 42 patients submitted to laparoscopy and hysteroscopy for the management of endometriosis. Sixteen of these patients were using oral contraceptives alone prior to hospital admission, while the remaining 26 were using them in combination with resveratrol. Inhibition of both aromatase and cyclo-oxygenase-2 expression was significantly greater in the eutopic endometrium of patients using combined drospirenone + resveratrol therapy compared with the endometrium of patients using oral contraceptives alone. Conclusion: These results suggest that resveratrol potentiates the effect of oral contraceptives in the management of endometriosis-associated dysmenorrhea by further decreasing aromatase and cyclo-oxygenase-2 expression in the endometrium.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-19T17:25:55Z No. of bitstreams: 1 Hugo Maia Jr.pdf: 2321618 bytes, checksum: fe0b7e2c8244ca1693f5e19add690514 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-06-04T16:40:03Z (GMT) No. of bitstreams: 1 Hugo Maia Jr.pdf: 2321618 bytes, checksum: fe0b7e2c8244ca1693f5e19add690514 (MD5)Made available in DSpace on 2014-06-04T16:40:03Z (GMT). No. of bitstreams: 1 Hugo Maia Jr.pdf: 2321618 bytes, checksum: fe0b7e2c8244ca1693f5e19add690514 (MD5) Previous issue date: 2012http://dx.doi.org/10.2147/IJWH.S36825reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAResveratrolDrospirenoneEndometriosisDysmenorrheaCyclo-oxygenase-2Contraceptive agentsAromataseAdvantages of the association of resveratrol with oral contraceptives for management of endometriosis-related painInternational Journal of Women's Healthinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALHugo Maia Jr.pdfHugo Maia Jr.pdfapplication/pdf2321618https://repositorio.ufba.br/bitstream/ri/15049/1/Hugo%20Maia%20Jr.pdffe0b7e2c8244ca1693f5e19add690514MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15049/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTHugo Maia Jr.pdf.txtHugo Maia Jr.pdf.txtExtracted texttext/plain27964https://repositorio.ufba.br/bitstream/ri/15049/3/Hugo%20Maia%20Jr.pdf.txtda9f11ed79de8cd1ab5afa87a3dd39dfMD53ri/150492022-07-05 14:03:13.421oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:13Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
dc.title.alternative.pt_BR.fl_str_mv International Journal of Women's Health
title Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
spellingShingle Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
Maia Junior, Hugo
Resveratrol
Drospirenone
Endometriosis
Dysmenorrhea
Cyclo-oxygenase-2
Contraceptive agents
Aromatase
title_short Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
title_full Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
title_fullStr Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
title_full_unstemmed Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
title_sort Advantages of the association of resveratrol with oral contraceptives for management of endometriosis-related pain
author Maia Junior, Hugo
author_facet Maia Junior, Hugo
Haddad, Clarice
Pinheiro, Nathanael
Casoy, Julio
author_role author
author2 Haddad, Clarice
Pinheiro, Nathanael
Casoy, Julio
author2_role author
author
author
dc.contributor.author.fl_str_mv Maia Junior, Hugo
Haddad, Clarice
Pinheiro, Nathanael
Casoy, Julio
Maia Junior, Hugo
Haddad, Clarice
Pinheiro, Nathanael
Casoy, Julio
dc.subject.por.fl_str_mv Resveratrol
Drospirenone
Endometriosis
Dysmenorrhea
Cyclo-oxygenase-2
Contraceptive agents
Aromatase
topic Resveratrol
Drospirenone
Endometriosis
Dysmenorrhea
Cyclo-oxygenase-2
Contraceptive agents
Aromatase
description Texto completo: acesso restrito. p. 543-549
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-06-04T16:40:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15049
dc.identifier.issn.none.fl_str_mv 1179-1411
dc.identifier.number.pt_BR.fl_str_mv v. 4, n. 1
identifier_str_mv 1179-1411
v. 4, n. 1
url http://repositorio.ufba.br/ri/handle/ri/15049
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.2147/IJWH.S36825
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