The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?

Detalhes bibliográficos
Autor(a) principal: Emiliano, Ana B. F.
Data de Publicação: 2007
Outros Autores: Cruz, Thomaz Rodrigues Porto da, Pannoni, Valerie, Fudge, Julie L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16009
Resumo: Texto completo: acesso restrito. p. 977-988
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spelling Emiliano, Ana B. F.Cruz, Thomaz Rodrigues Porto daPannoni, ValerieFudge, Julie L.Emiliano, Ana B. F.Cruz, Thomaz Rodrigues Porto daPannoni, ValerieFudge, Julie L.2014-09-09T16:13:29Z20070893-133Xhttp://repositorio.ufba.br/ri/handle/ri/16009v. 32, n. 5Texto completo: acesso restrito. p. 977-988Oxytocin (OT) is a neuropeptide synthesized in the paraventricular (PVN) and supraoptic nuclei (SON) in the hypothalamus. Although OT is more commonly known for its role in the milk-ejection reflex, in recent years research has indicated that OT participates in the expression of social behavior, memory processing, modulation of fear, and stress responses. The demonstration that OT influences affiliative behaviors, such as parental care and reproduction, and decreases anxiety has lead to speculations that it may have a role in mood disorders. Evidence from pharmacologic studies, pointing out the modulation of the OT system by serotonin, has argued in favor of OT as a mediator of serotonin reuptake inhibitors (SSRIs) antidepressant properties. In the present study, we investigated the distribution and overlap of OT-labeled cells and serotonin transporter (5-HTT) immunoreactive (IR) fibers in the Macaque hypothalamus, utilizing immunocytochemical and double-immunofluorescent techniques. Consistent with previous reports, the distribution of OT-labeled cells in the hypothalamus is confined to the PVN and SON. In these nuclei, we demonstrate that the distribution of 5-HTT-labeled fibers follows the distribution of OT-labeled cells. Overlap of OT-labeled neurons and 5-HTT-IR fibers occurs in the parvicellular, magnocellular, dorsal, and posterior subdivisions of the PVN. In the SON, 5-HTT-labeled fibers and OT-labeled cells overlap in the ventromedial subdivision and in the 'capsular' part of the dorsolateral SON. These findings provide neuroanatomic support for the idea that SSRIs' therapeutic effects on social affiliation and anxiety may be mediated in part through components of the OT system.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-01-24T14:15:08Z No. of bitstreams: 1 10.1038sj.npp.1301206.pdf: 647725 bytes, checksum: 9beb87f67bde71d35e2555df2662ab6c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T16:13:29Z (GMT) No. of bitstreams: 1 10.1038sj.npp.1301206.pdf: 647725 bytes, checksum: 9beb87f67bde71d35e2555df2662ab6c (MD5)Made available in DSpace on 2014-09-09T16:13:29Z (GMT). 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dc.title.pt_BR.fl_str_mv The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
dc.title.alternative.pt_BR.fl_str_mv Neuropsychopharmacology
title The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
spellingShingle The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
Emiliano, Ana B. F.
Paraventricular nucleus
Supraoptic nucleus
Affiliation
Depression
Stress
Suckling
title_short The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
title_full The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
title_fullStr The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
title_full_unstemmed The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
title_sort The interface of oxytocin-labeled cells and serotonin transporter- containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects?
author Emiliano, Ana B. F.
author_facet Emiliano, Ana B. F.
Cruz, Thomaz Rodrigues Porto da
Pannoni, Valerie
Fudge, Julie L.
author_role author
author2 Cruz, Thomaz Rodrigues Porto da
Pannoni, Valerie
Fudge, Julie L.
author2_role author
author
author
dc.contributor.author.fl_str_mv Emiliano, Ana B. F.
Cruz, Thomaz Rodrigues Porto da
Pannoni, Valerie
Fudge, Julie L.
Emiliano, Ana B. F.
Cruz, Thomaz Rodrigues Porto da
Pannoni, Valerie
Fudge, Julie L.
dc.subject.por.fl_str_mv Paraventricular nucleus
Supraoptic nucleus
Affiliation
Depression
Stress
Suckling
topic Paraventricular nucleus
Supraoptic nucleus
Affiliation
Depression
Stress
Suckling
description Texto completo: acesso restrito. p. 977-988
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2014-09-09T16:13:29Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16009
dc.identifier.issn.none.fl_str_mv 0893-133X
dc.identifier.number.pt_BR.fl_str_mv v. 32, n. 5
identifier_str_mv 0893-133X
v. 32, n. 5
url http://repositorio.ufba.br/ri/handle/ri/16009
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1038/sj.npp.1301206
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