Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia

Detalhes bibliográficos
Autor(a) principal: Mendonça, J. S.
Data de Publicação: 2004
Outros Autores: Yamaguti, A., Corrêa, J. C., Badaró, Roberto José da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7059
Resumo: p.90-100
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spelling Mendonça, J. S.Yamaguti, A.Corrêa, J. C.Badaró, Roberto José da SilvaMendonça, J. S.Yamaguti, A.Corrêa, J. C.Badaró, Roberto José da Silva2012-10-26T17:03:08Z2012-10-26T17:03:08Z2004-021413-8670http://www.repositorio.ufba.br/ri/handle/ri/7059v. 8, n. 1p.90-100Community-acquired pneumonia is very common, but some of the cases do require hospitalization for treatment, particularly when older patients and/or co-morbidities are involved; both "typical" and "atypical" respiratory pathogens take part etiologically, and there is increasing concern about the emergence of resistance. There is interest in therapeutic options that can: a) comprehend such a spectrum of bacteria and resistance; b) allow parenteral to oral sequential treatment. We made a multicenter, prospective and randomized trial to compare the "standard" treatment of ceftriaxone IV alone or in combination with erythromycin IV, followed by clarithromycin PO (ceftriaxone treatment arm), with gatifloxacin IV, followed by oral administration (gatifloxacin treatment arm). The need for hospitalization was based on clinical criteria as judged by the investigators. Standardized criteria for diagnosis and follow-up were employed. Fifty-six patients were enrolled, with 48% over 65 years old, and there were frequent co-morbidities. Of these, 51 were clinically evaluable, 26 in the gatifloxacin and 25 in the ceftriaxone arm, with comparable success rates, 92% and 88%, respectively, even when major prognostic factors were considered. There were no serious adverse events or significant laboratory value changes attributable to the study drugs. Gatifloxacin as monotherapy (initially IV then orally until completion of treatment) was shown to be effective and safe, comparable to ceftriaxone IV alone or in combination with a macrolide (initially IV then orally until completion of treatment), in empirical therapy for community-acquired pneumonias, for patients that, at the physician s discretion, require initial treatment as inpatients.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-10-26T17:03:08Z No. of bitstreams: 1 Mendonça, J.S..pdf: 43305 bytes, checksum: 54ba489831f65ee1a2f1fee58826d0b3 (MD5)Made available in DSpace on 2012-10-26T17:03:08Z (GMT). No. of bitstreams: 1 Mendonça, J.S..pdf: 43305 bytes, checksum: 54ba489831f65ee1a2f1fee58826d0b3 (MD5) Previous issue date: 2004-02SalvadorThe Brazilian Journal of Infectious Diseases and Contexto Publishinghttp://dx.doi.org/10.1590/S1413-86702004000100006reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACeftriaxoneGatifloxacinPneumoniasGatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumoniaBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALMendonça, J.S..pdfMendonça, J.S..pdfapplication/pdf43305https://repositorio.ufba.br/bitstream/ri/7059/1/Mendon%c3%a7a%2c%20J.S..pdf54ba489831f65ee1a2f1fee58826d0b3MD51LICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/7059/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52TEXTMendonça, J.S..pdf.txtMendonça, J.S..pdf.txtExtracted texttext/plain37406https://repositorio.ufba.br/bitstream/ri/7059/3/Mendon%c3%a7a%2c%20J.S..pdf.txt850de2ecb7d68380fee0cd2f635bbc91MD53ri/70592022-07-05 14:04:04.179oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:04Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Infectious Diseases
title Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
spellingShingle Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
Mendonça, J. S.
Ceftriaxone
Gatifloxacin
Pneumonias
title_short Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
title_full Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
title_fullStr Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
title_full_unstemmed Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
title_sort Gatifloxacin in the treatment of community-acquired pneumonias. A comparative trial of ceftriaxone, with or without macrolides, in hospitalized adult patients with mild to moderately severe pneumonia
author Mendonça, J. S.
author_facet Mendonça, J. S.
Yamaguti, A.
Corrêa, J. C.
Badaró, Roberto José da Silva
author_role author
author2 Yamaguti, A.
Corrêa, J. C.
Badaró, Roberto José da Silva
author2_role author
author
author
dc.contributor.author.fl_str_mv Mendonça, J. S.
Yamaguti, A.
Corrêa, J. C.
Badaró, Roberto José da Silva
Mendonça, J. S.
Yamaguti, A.
Corrêa, J. C.
Badaró, Roberto José da Silva
dc.subject.por.fl_str_mv Ceftriaxone
Gatifloxacin
Pneumonias
topic Ceftriaxone
Gatifloxacin
Pneumonias
description p.90-100
publishDate 2004
dc.date.issued.fl_str_mv 2004-02
dc.date.accessioned.fl_str_mv 2012-10-26T17:03:08Z
dc.date.available.fl_str_mv 2012-10-26T17:03:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7059
dc.identifier.issn.none.fl_str_mv 1413-8670
dc.identifier.number.pt_BR.fl_str_mv v. 8, n. 1
identifier_str_mv 1413-8670
v. 8, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/7059
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
publisher.none.fl_str_mv The Brazilian Journal of Infectious Diseases and Contexto Publishing
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S1413-86702004000100006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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