Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.

Detalhes bibliográficos
Autor(a) principal: Garcia, Rosa
Data de Publicação: 2006
Outros Autores: Badaró, Roberto José da Silva, Martins Netto, Eduardo, Silva, Marcio, Amorin, Fabio S., Ramos, André, Vaida, Florin, Brites, Carlos, Schooley, Robert T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13713
Resumo: p.1248–1252
id UFBA-2_4d7f3481e826161c6c179ea6764d2dfc
oai_identifier_str oai:repositorio.ufba.br:ri/13713
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Garcia, RosaBadaró, Roberto José da SilvaMartins Netto, EduardoSilva, MarcioAmorin, Fabio S.Ramos, AndréVaida, FlorinBrites, CarlosSchooley, Robert T.Garcia, RosaBadaró, Roberto José da SilvaMartins Netto, EduardoSilva, MarcioAmorin, Fabio S.Ramos, AndréVaida, FlorinBrites, CarlosSchooley, Robert T.2013-11-18T21:03:43Z20060889-2229http://repositorio.ufba.br/ri/handle/ri/13713v.22 n. 12p.1248–1252Antiretroviral therapy success is highly dependent on the ability of the patient to fully adhere to the prescribed treatment regimen. We present the results of a cross-sectional study that evaluates the predictive value of a self-administered questionnaire of adherence to antiretroviral (ARV) therapy. Study participants were interviewed using a 36-item Patient Medication Adherence Questionnaire (PMAQ) designed to assess knowledge about ARV therapy, motivation to adhere to treatment, and behavioral skills. Plasma HIV-1 RNA levels were correlated with the results obtained from the PMAQ. Of the 182 study participants, 82 (45%) were receiving their initial ARV regimen. Of the remaining patients, 39 (21%) and 61 (34%) were on a second or additional ARV regimen, respectively. An undetectable viral load was documented in 47/62 (76%) patients on their first regimen who reported missing medication on less than 4 days in the last 3 months. The PMAQ had a higher predictive value of plasma viral suppression for patients in the initial regimen than for patients in salvage therapy. The overall predictive value of the PMAQ to identify adherence was 74%, and 59% for nonadherence, with an overall efficacy of 64%. Of the 74 patients (45%) who did not understand the concept of antiretroviral therapy, 80% were failing or had previously failed the ARV treatment. Of 35 patients with doubts about their HIV status or skeptical of the benefits of ARV therapy, 29 (84%) were nonadherent. Despite the positive predictive value of PMAQ in identifying adherence, self-reported adherence is not a sufficiently precise predictor of treatment success to substitute for viral load monitoring. On the other hand, the use of such an instrument to identify factors associated with nonadherence provides an excellent opportunity to apply early intervention designed to specifically address factors that might be contributing to the lack of adherence prior to regimen failure.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-06-17T12:34:42Z No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5)Rejected by Rodrigo Meirelles (rodrigomei@ufba.br), reason: on 2013-11-14T13:33:32Z (GMT)Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-18T12:19:33Z No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-18T21:03:42Z (GMT) No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5)Made available in DSpace on 2013-11-18T21:03:43Z (GMT). No. of bitstreams: 1 aid.2006.22.pdf: 126417 bytes, checksum: 663103b2e67ef1be722e22478b1b254d (MD5) Previous issue date: 2006http://dx.doi.org/10.1089/aid.2006.22.1248reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.Aids Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALaid.2006.22.pdfaid.2006.22.pdfapplication/pdf126417https://repositorio.ufba.br/bitstream/ri/13713/1/aid.2006.22.pdf663103b2e67ef1be722e22478b1b254dMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13713/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTaid.2006.22.pdf.txtaid.2006.22.pdf.txtExtracted texttext/plain26233https://repositorio.ufba.br/bitstream/ri/13713/3/aid.2006.22.pdf.txtbb3dbdad86fa53a79c8608cf65391484MD53ri/137132022-07-05 14:03:00.409oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
dc.title.alternative.pt_BR.fl_str_mv Aids Research and Human Retroviruses
title Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
spellingShingle Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
Garcia, Rosa
title_short Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
title_full Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
title_fullStr Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
title_full_unstemmed Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
title_sort Cross-Sectional Study to Evaluate Factors Associated with Adherence to Antiretroviral Therapy by Brazilian HIV-Infected Patients.
author Garcia, Rosa
author_facet Garcia, Rosa
Badaró, Roberto José da Silva
Martins Netto, Eduardo
Silva, Marcio
Amorin, Fabio S.
Ramos, André
Vaida, Florin
Brites, Carlos
Schooley, Robert T.
author_role author
author2 Badaró, Roberto José da Silva
Martins Netto, Eduardo
Silva, Marcio
Amorin, Fabio S.
Ramos, André
Vaida, Florin
Brites, Carlos
Schooley, Robert T.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Garcia, Rosa
Badaró, Roberto José da Silva
Martins Netto, Eduardo
Silva, Marcio
Amorin, Fabio S.
Ramos, André
Vaida, Florin
Brites, Carlos
Schooley, Robert T.
Garcia, Rosa
Badaró, Roberto José da Silva
Martins Netto, Eduardo
Silva, Marcio
Amorin, Fabio S.
Ramos, André
Vaida, Florin
Brites, Carlos
Schooley, Robert T.
description p.1248–1252
publishDate 2006
dc.date.issued.fl_str_mv 2006
dc.date.accessioned.fl_str_mv 2013-11-18T21:03:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13713
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v.22 n. 12
identifier_str_mv 0889-2229
v.22 n. 12
url http://repositorio.ufba.br/ri/handle/ri/13713
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1089/aid.2006.22.1248
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/13713/1/aid.2006.22.pdf
https://repositorio.ufba.br/bitstream/ri/13713/2/license.txt
https://repositorio.ufba.br/bitstream/ri/13713/3/aid.2006.22.pdf.txt
bitstream.checksum.fl_str_mv 663103b2e67ef1be722e22478b1b254d
ff6eaa8b858ea317fded99f125f5fcd0
bb3dbdad86fa53a79c8608cf65391484
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1801502505373270016

Registros relacionados