Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/34218 |
Resumo: | Introduction: Sickle cell disease (SCD) children have a high susceptibility to pneumococcal infection. For this reason, they are routinely immunized with pneumococcal vaccines and use antibiotic prophylaxis (AP). Hypothesis/Gap Statement: Yet, little is known about SCD children’s gut microbiota. If antibiotic-resistant Enterobacterales may colonize people on AP, we hypothesized that SCD children on AP are colonized by resistant enterobacteria species. Objective: To evaluate the effect of continuous AP on Enterobacterales gut colonization from children with SCD. Methodology: We analysed 30 faecal swabs from SCD children on AP and 21 swabs from children without the same condition. Enterobacterales was isolated on MacConkey agar plates and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (bioMérieux, Marcy l'Etoile, France). We performed the antibiogram by Vitek 2 system (bioMérieux, Marcy l'Etoile, France), and the resistance genes were identified by multiplex PCR. Results: We found four different species with resistance to one or more different antibiotic types in the AP-SCD children’s group: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, and Citrobacter farmeri. Colonization by resistant E. coli was associated with AP (prevalence ratio 2.69, 95% confidence interval [CI], 1.98–3.67, P<0.001). Strains producing extended-spectrum β-lactamases (ESBL) were identified only in SCD children, E. coli, 4/30 (13%), and K. pneumoniae, 2/30 (7%). The ESBL-producing Enterobacterales were associated with penicillin G benzathine use (95 % CI, 22.91–86.71, P<0.001). CTX-M-1 was the most prevalent among ESBL-producers (3/6, 50%), followed by CTX-M-9 (2/6, 33%), and CTX-M-2 (1/6, 17%). Conclusion: Resistant enterobacteria colonize SCD children on AP, and this therapy raises the chance of ESBL-producing Enterobacterales colonization. Future studies should focus on prophylactic vaccines as exclusive therapy against pneumococcal infections. |
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Monteiro, Adriano de Souza SantosOliveira, Eduardo Gomes deSantos, Djanilson Barbosa dosCordeiro, Soraia MachadoCouto, Ricardo DavidCouto, Fábio DavidMonteiro, Adriano de Souza SantosOliveira, Eduardo Gomes deSantos, Djanilson Barbosa dosCordeiro, Soraia MachadoCouto, Ricardo DavidCouto, Fábio David2021-09-11T10:30:06Z2021-09-11T10:30:06Z2021MONTEIRO, A. S. S. et al. Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?. Journal of Medical Microbiology, v. 70, n. 9, p. 001414, 2021.0022-2615http://repositorio.ufba.br/ri/handle/ri/34218v.70, n.9Introduction: Sickle cell disease (SCD) children have a high susceptibility to pneumococcal infection. For this reason, they are routinely immunized with pneumococcal vaccines and use antibiotic prophylaxis (AP). Hypothesis/Gap Statement: Yet, little is known about SCD children’s gut microbiota. If antibiotic-resistant Enterobacterales may colonize people on AP, we hypothesized that SCD children on AP are colonized by resistant enterobacteria species. Objective: To evaluate the effect of continuous AP on Enterobacterales gut colonization from children with SCD. Methodology: We analysed 30 faecal swabs from SCD children on AP and 21 swabs from children without the same condition. Enterobacterales was isolated on MacConkey agar plates and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (bioMérieux, Marcy l'Etoile, France). We performed the antibiogram by Vitek 2 system (bioMérieux, Marcy l'Etoile, France), and the resistance genes were identified by multiplex PCR. Results: We found four different species with resistance to one or more different antibiotic types in the AP-SCD children’s group: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, and Citrobacter farmeri. Colonization by resistant E. coli was associated with AP (prevalence ratio 2.69, 95% confidence interval [CI], 1.98–3.67, P<0.001). Strains producing extended-spectrum β-lactamases (ESBL) were identified only in SCD children, E. coli, 4/30 (13%), and K. pneumoniae, 2/30 (7%). The ESBL-producing Enterobacterales were associated with penicillin G benzathine use (95 % CI, 22.91–86.71, P<0.001). CTX-M-1 was the most prevalent among ESBL-producers (3/6, 50%), followed by CTX-M-9 (2/6, 33%), and CTX-M-2 (1/6, 17%). Conclusion: Resistant enterobacteria colonize SCD children on AP, and this therapy raises the chance of ESBL-producing Enterobacterales colonization. Future studies should focus on prophylactic vaccines as exclusive therapy against pneumococcal infections.Submitted by Adriano Monteiro (assmonteiro@hotmail.com) on 2021-09-10T00:42:12Z No. of bitstreams: 1 Monteiro et al 2021.pdf: 681887 bytes, checksum: af79ad6cecede41ef0173f92a4b842b6 (MD5)Approved for entry into archive by Setor de Periódicos (per_macedocosta@ufba.br) on 2021-09-11T10:30:06Z (GMT) No. of bitstreams: 1 Monteiro et al 2021.pdf: 681887 bytes, checksum: af79ad6cecede41ef0173f92a4b842b6 (MD5)Made available in DSpace on 2021-09-11T10:30:06Z (GMT). No. of bitstreams: 1 Monteiro et al 2021.pdf: 681887 bytes, checksum: af79ad6cecede41ef0173f92a4b842b6 (MD5) Previous issue date: 2021-09-03This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) - Brasil [grant code SUS0036/2018]; and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Brasil [grant code 001].United KingdomJournal of Medical Microbiology, Microbiology SocietyBrasilhttps://doi.org/10.1099/jmm.0.001414reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBASickle cell diseaseAntibiotic prophylaxisGut microbiotaEnterobacteralesMultidrug resistanceExtended-spectrum β-lactamase (ESBL)-producing EnterobacteralesSickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALMonteiro et al 2021.pdfMonteiro et al 2021.pdfapplication/pdf681887https://repositorio.ufba.br/bitstream/ri/34218/1/Monteiro%20et%20al%202021.pdfaf79ad6cecede41ef0173f92a4b842b6MD51LICENSElicense.txtlicense.txttext/plain1582https://repositorio.ufba.br/bitstream/ri/34218/2/license.txt907e2b7d511fb2c3e42dbdd41a6197c6MD52TEXTMonteiro et al 2021.pdf.txtMonteiro et al 2021.pdf.txtExtracted texttext/plain41392https://repositorio.ufba.br/bitstream/ri/34218/3/Monteiro%20et%20al%202021.pdf.txt6dd2f16d087c051e1eee4659ff0b75dbMD53ri/342182022-10-22 19:09:15.579oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-22T22:09:15Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
title |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
spellingShingle |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? Monteiro, Adriano de Souza Santos Sickle cell disease Antibiotic prophylaxis Gut microbiota Enterobacterales Multidrug resistance Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales |
title_short |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
title_full |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
title_fullStr |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
title_full_unstemmed |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
title_sort |
Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? |
author |
Monteiro, Adriano de Souza Santos |
author_facet |
Monteiro, Adriano de Souza Santos Oliveira, Eduardo Gomes de Santos, Djanilson Barbosa dos Cordeiro, Soraia Machado Couto, Ricardo David Couto, Fábio David |
author_role |
author |
author2 |
Oliveira, Eduardo Gomes de Santos, Djanilson Barbosa dos Cordeiro, Soraia Machado Couto, Ricardo David Couto, Fábio David |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Monteiro, Adriano de Souza Santos Oliveira, Eduardo Gomes de Santos, Djanilson Barbosa dos Cordeiro, Soraia Machado Couto, Ricardo David Couto, Fábio David Monteiro, Adriano de Souza Santos Oliveira, Eduardo Gomes de Santos, Djanilson Barbosa dos Cordeiro, Soraia Machado Couto, Ricardo David Couto, Fábio David |
dc.subject.por.fl_str_mv |
Sickle cell disease Antibiotic prophylaxis Gut microbiota Enterobacterales Multidrug resistance Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales |
topic |
Sickle cell disease Antibiotic prophylaxis Gut microbiota Enterobacterales Multidrug resistance Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales |
description |
Introduction: Sickle cell disease (SCD) children have a high susceptibility to pneumococcal infection. For this reason, they are routinely immunized with pneumococcal vaccines and use antibiotic prophylaxis (AP). Hypothesis/Gap Statement: Yet, little is known about SCD children’s gut microbiota. If antibiotic-resistant Enterobacterales may colonize people on AP, we hypothesized that SCD children on AP are colonized by resistant enterobacteria species. Objective: To evaluate the effect of continuous AP on Enterobacterales gut colonization from children with SCD. Methodology: We analysed 30 faecal swabs from SCD children on AP and 21 swabs from children without the same condition. Enterobacterales was isolated on MacConkey agar plates and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (bioMérieux, Marcy l'Etoile, France). We performed the antibiogram by Vitek 2 system (bioMérieux, Marcy l'Etoile, France), and the resistance genes were identified by multiplex PCR. Results: We found four different species with resistance to one or more different antibiotic types in the AP-SCD children’s group: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, and Citrobacter farmeri. Colonization by resistant E. coli was associated with AP (prevalence ratio 2.69, 95% confidence interval [CI], 1.98–3.67, P<0.001). Strains producing extended-spectrum β-lactamases (ESBL) were identified only in SCD children, E. coli, 4/30 (13%), and K. pneumoniae, 2/30 (7%). The ESBL-producing Enterobacterales were associated with penicillin G benzathine use (95 % CI, 22.91–86.71, P<0.001). CTX-M-1 was the most prevalent among ESBL-producers (3/6, 50%), followed by CTX-M-9 (2/6, 33%), and CTX-M-2 (1/6, 17%). Conclusion: Resistant enterobacteria colonize SCD children on AP, and this therapy raises the chance of ESBL-producing Enterobacterales colonization. Future studies should focus on prophylactic vaccines as exclusive therapy against pneumococcal infections. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-09-11T10:30:06Z |
dc.date.available.fl_str_mv |
2021-09-11T10:30:06Z |
dc.date.issued.fl_str_mv |
2021 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MONTEIRO, A. S. S. et al. Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?. Journal of Medical Microbiology, v. 70, n. 9, p. 001414, 2021. |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/34218 |
dc.identifier.issn.none.fl_str_mv |
0022-2615 |
dc.identifier.number.pt_BR.fl_str_mv |
v.70, n.9 |
identifier_str_mv |
MONTEIRO, A. S. S. et al. Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?. Journal of Medical Microbiology, v. 70, n. 9, p. 001414, 2021. 0022-2615 v.70, n.9 |
url |
http://repositorio.ufba.br/ri/handle/ri/34218 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Journal of Medical Microbiology, Microbiology Society |
dc.publisher.country.fl_str_mv |
Brasil |
publisher.none.fl_str_mv |
Journal of Medical Microbiology, Microbiology Society |
dc.source.pt_BR.fl_str_mv |
https://doi.org/10.1099/jmm.0.001414 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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