Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection

Detalhes bibliográficos
Autor(a) principal: Tatfeng, Y. M.
Data de Publicação: 2010
Outros Autores: Agbonlahor, D. E., Amegor, O. F.
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/22705
Resumo: Keywords: Cytokines – Childhood haemoglobinopathies - Uncomplicated malaria
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spelling Tatfeng, Y. M.Agbonlahor, D. E.Amegor, O. F.Tatfeng, Y. M.Agbonlahor, D. E.Amegor, O. F.2017-06-01T19:19:36Z2017-06-01T19:19:36Z2010R. Ci. méd. biol., v. 9, Supl.1, p. 13-16, 20101677-5090http://repositorio.ufba.br/ri/handle/ri/22705v.9, n.1Keywords: Cytokines – Childhood haemoglobinopathies - Uncomplicated malariaThe relative balance between Th1 and Th2 cytokines appears crucial in the outcome of infections. We assayed some Th1 cytokines (interleukin-2 (IL-2) and gamma interferon (IFN-g) and Th2 cytokines (IL-4 and IL-10) in homozygous haemoglobin (Hb) AA, heterozygous HbAS genotyped and sickle cell (HbSS) individuals with uncomplicated P. falciparum malaria to determine the group with the strongest cytokine response to P. falciparum malaria. Levels of Th1 and Th2 cytokines of 111 children with uncomplicated malaria and 89 healthy controls were determined by Enzyme Linked Immunosorbent Assay and haematological parameters were estimated using standard haematological techniques. Th1 and Th2 cytokine levels were significantly higher in HbAA, HbAS genotyped patients compared to their respective healthy controls (P<0.05). IFN ã, IL-2 and and IL-10 were significantly elevated in HbAA compared to HbAS and HbSS subjects (P<0.05). The mean haematological parameters (total white cell count, monocyte) of HbSS infected children were significantly higher compared to that of HbAA and HbAS subjects (P<0.05), however, their mean packed cell volume was significantly lower compared to others (P<0.05). Even though the role of cytokines in immune response is yet to be fully understood, these findings may suggest a stronger cytokine response in HbAA than HbAS and HbSS individuals when infected with malaria.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2017-06-01T19:19:36Z No. of bitstreams: 1 3_v.9_1.pdf: 117477 bytes, checksum: cefe0188d16f52e415231a998f92a104 (MD5)Made available in DSpace on 2017-06-01T19:19:36Z (GMT). No. of bitstreams: 1 3_v.9_1.pdf: 117477 bytes, checksum: cefe0188d16f52e415231a998f92a104 (MD5) Previous issue date: 2010-01SalvadorInstituto de Ciências da Saúde/ Universidade Federal da BahiaBrasilhttp://www.portalseer.ufba.br/index.php/cmbio/article/view/4634/3472reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACitocinasHemoglobinopatiasCriançasMalária não complicadaMeasurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infectionRevista de Ciências Médicas e Biológicasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessporORIGINAL3_v.9_1.pdf3_v.9_1.pdfapplication/pdf117477https://repositorio.ufba.br/bitstream/ri/22705/1/3_v.9_1.pdfcefe0188d16f52e415231a998f92a104MD51LICENSElicense.txtlicense.txttext/plain1383https://repositorio.ufba.br/bitstream/ri/22705/2/license.txt05eca2f01d0b3307819d0369dab18a34MD52TEXT3_v.9_1.pdf.txt3_v.9_1.pdf.txtExtracted texttext/plain18920https://repositorio.ufba.br/bitstream/ri/22705/3/3_v.9_1.pdf.txt6b27103d54d59d35b10837d76044d80aMD53ri/227052022-11-01 13:57:27.427oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-11-01T16:57:27Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
dc.title.alternative.pt_BR.fl_str_mv Revista de Ciências Médicas e Biológicas
title Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
spellingShingle Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
Tatfeng, Y. M.
Citocinas
Hemoglobinopatias
Crianças
Malária não complicada
title_short Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
title_full Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
title_fullStr Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
title_full_unstemmed Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
title_sort Measurement of some Th1, Th2 cytokines and white cell count in childhood haemoglobinopathies with uncomplicated malaria infection
author Tatfeng, Y. M.
author_facet Tatfeng, Y. M.
Agbonlahor, D. E.
Amegor, O. F.
author_role author
author2 Agbonlahor, D. E.
Amegor, O. F.
author2_role author
author
dc.contributor.author.fl_str_mv Tatfeng, Y. M.
Agbonlahor, D. E.
Amegor, O. F.
Tatfeng, Y. M.
Agbonlahor, D. E.
Amegor, O. F.
dc.subject.por.fl_str_mv Citocinas
Hemoglobinopatias
Crianças
Malária não complicada
topic Citocinas
Hemoglobinopatias
Crianças
Malária não complicada
description Keywords: Cytokines – Childhood haemoglobinopathies - Uncomplicated malaria
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2017-06-01T19:19:36Z
dc.date.available.fl_str_mv 2017-06-01T19:19:36Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv R. Ci. méd. biol., v. 9, Supl.1, p. 13-16, 2010
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/22705
dc.identifier.issn.none.fl_str_mv 1677-5090
dc.identifier.number.pt_BR.fl_str_mv v.9, n.1
identifier_str_mv R. Ci. méd. biol., v. 9, Supl.1, p. 13-16, 2010
1677-5090
v.9, n.1
url http://repositorio.ufba.br/ri/handle/ri/22705
dc.language.iso.fl_str_mv por
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.source.pt_BR.fl_str_mv http://www.portalseer.ufba.br/index.php/cmbio/article/view/4634/3472
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