The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus

Detalhes bibliográficos
Autor(a) principal: Bahia, Fabianna Márcia Maranhão
Data de Publicação: 2011
Outros Autores: Novais, Vinicius, Evans, Jennifer, Marchand, Chloe Le, Martins Netto, Eduardo, Page, Kimberly, Alves, Carlos Roberto Brites
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/17651
Resumo: Texto completo: acesso restrito. p. 202-207
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spelling Bahia, Fabianna Márcia MaranhãoNovais, ViniciusEvans, JenniferMarchand, Chloe LeMartins Netto, EduardoPage, KimberlyAlves, Carlos Roberto BritesBahia, Fabianna Márcia MaranhãoNovais, ViniciusEvans, JenniferMarchand, Chloe LeMartins Netto, EduardoPage, KimberlyAlves, Carlos Roberto Brites2015-05-11T14:35:23Z20111525-4135http://repositorio.ufba.br/ri/handle/ri/17651v. 57, Supl. 3Texto completo: acesso restrito. p. 202-207Background: HIV, hepatitis C (HCV), and human T-cell lymphotropic virus I (HTLV-1) are associated with high global burdens of disease, notably in resource-poor locales. They share similar routes of transmission and cause chronic infections with associated morbidity. We performed a cross-sectional study to assess the impact of HTLV-1 infection on clinical outcomes in HIV/HCV-coinfected patients. Methods: We enrolled 102 (72.3%) with HIV/HCV coinfection (Group 1) and 39 (27.7%) triply infected with HIV, HCV, and HTLV-1 (Group 2). We reviewed medical records of two groups of patients followed in two outpatients services in Salvador, Brazil. We collected and compared demographic, behavioral-related information, immunologic, virologic, and histologic parameters for HIV-1 and HCV infection. Results: Demographics, virologic, and immunologic characteristics were similar in the two groups; a higher proportion of triply infected patients (Group 2) reported any history of injection drug use compared with dually infected (Group 1) patients (75% vs 45.8%; P = 0.003). No differences were seen between groups in HIV clinical outcomes (CD4 count and viral load). Alanine aminotransferase levels were significantly higher in HIV/HCV-coinfected patients (P = 0.045). Liver fibrosis damage based on Metavir scores was similar between groups (0.97) but was worse with lower CD4 cell count (under 200 cells/mm3) (P = 0.01). Conclusions: HIV/HTLV-1 and HIV/HCV coinfections may worsen clinical related outcomes, but virologic and immunologic outcomes were similar in both groups. Hepatic measures were worse in patients with more severe immunosuppression.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-11T11:33:31Z No. of bitstreams: 1 Fabianna Bahia.pdf: 104918 bytes, checksum: ec2a24fc5acd73f655fb70981e2f5fff (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-05-11T14:35:23Z (GMT) No. of bitstreams: 1 Fabianna Bahia.pdf: 104918 bytes, checksum: ec2a24fc5acd73f655fb70981e2f5fff (MD5)Made available in DSpace on 2015-05-11T14:35:23Z (GMT). No. of bitstreams: 1 Fabianna Bahia.pdf: 104918 bytes, checksum: ec2a24fc5acd73f655fb70981e2f5fff (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1097/QAI.0b013e31821e9a1ereponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHIV-1 and HCV coinfectionHIV-1HCVHTLV-1 triple infectionThe Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C VirusJAIDS Journal of Acquired Immune Deficiency Syndromesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01Brasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17651/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALFabianna Bahia.pdfFabianna Bahia.pdfapplication/pdf104918https://repositorio.ufba.br/bitstream/ri/17651/1/Fabianna%20Bahia.pdfec2a24fc5acd73f655fb70981e2f5fffMD51TEXTFabianna Bahia.pdf.txtFabianna Bahia.pdf.txtExtracted texttext/plain30711https://repositorio.ufba.br/bitstream/ri/17651/3/Fabianna%20Bahia.pdf.txt41bb716b950594ee5e66c4a1422448d6MD53ri/176512022-07-05 14:05:18.526oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
dc.title.alternative.pt_BR.fl_str_mv JAIDS Journal of Acquired Immune Deficiency Syndromes
title The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
spellingShingle The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
Bahia, Fabianna Márcia Maranhão
HIV-1 and HCV coinfection
HIV-1
HCV
HTLV-1 triple infection
title_short The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
title_full The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
title_fullStr The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
title_full_unstemmed The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
title_sort The Impact of Human T-Cell Lymphotropic Virus I Infection on Clinical and Immunologic Outcomes in Patients Coinfected With HIV and Hepatitis C Virus
author Bahia, Fabianna Márcia Maranhão
author_facet Bahia, Fabianna Márcia Maranhão
Novais, Vinicius
Evans, Jennifer
Marchand, Chloe Le
Martins Netto, Eduardo
Page, Kimberly
Alves, Carlos Roberto Brites
author_role author
author2 Novais, Vinicius
Evans, Jennifer
Marchand, Chloe Le
Martins Netto, Eduardo
Page, Kimberly
Alves, Carlos Roberto Brites
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bahia, Fabianna Márcia Maranhão
Novais, Vinicius
Evans, Jennifer
Marchand, Chloe Le
Martins Netto, Eduardo
Page, Kimberly
Alves, Carlos Roberto Brites
Bahia, Fabianna Márcia Maranhão
Novais, Vinicius
Evans, Jennifer
Marchand, Chloe Le
Martins Netto, Eduardo
Page, Kimberly
Alves, Carlos Roberto Brites
dc.subject.por.fl_str_mv HIV-1 and HCV coinfection
HIV-1
HCV
HTLV-1 triple infection
topic HIV-1 and HCV coinfection
HIV-1
HCV
HTLV-1 triple infection
description Texto completo: acesso restrito. p. 202-207
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2015-05-11T14:35:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/17651
dc.identifier.issn.none.fl_str_mv 1525-4135
dc.identifier.number.pt_BR.fl_str_mv v. 57, Supl. 3
identifier_str_mv 1525-4135
v. 57, Supl. 3
url http://repositorio.ufba.br/ri/handle/ri/17651
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1097/QAI.0b013e31821e9a1e
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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