Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies

Detalhes bibliográficos
Autor(a) principal: Atta, Ajax Mercês
Data de Publicação: 2010
Outros Autores: Oliveira, Isabela S., Sousa, Gabriel Menezes de, Paraná, Raymundo, Atta, Maria Luiza Brito de Sousa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6048
Resumo: Trabalho completo: acesso restrito, p. 53–56
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spelling Atta, Ajax MercêsOliveira, Isabela S.Sousa, Gabriel Menezes deParaná, RaymundoAtta, Maria Luiza Brito de SousaAtta, Ajax MercêsOliveira, Isabela S.Sousa, Gabriel Menezes deParaná, RaymundoAtta, Maria Luiza Brito de Sousa2012-06-01T18:34:47Z2010-020882-4010http://www.repositorio.ufba.br/ri/handle/ri/6048v. 48, n. 2Trabalho completo: acesso restrito, p. 53–56This work investigated the serum cytokine profile (IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF) of hepatitis C virus (HCV) carriers with autoimmunity. Forty-seven HCV carriers and 28 healthy controls were evaluated. Cytokine levels were measured by ELISA. Patients and controls presented similar levels of IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF (p > 0.05). Cryoglobulinaemic HCV carriers had increased IL-2 (p = 0.013), IL-5 (p = 0.018) and BAFF (p = 0.050). IFN-γ level was decreased in HCV carriers with rheumatoid factor in comparison with those that were RF-seronegative (p = 0.035). Patients with β2GPI IgA antibodies when were compared with those without this autoantibody, had more serum IL-2 (p = 0.009), IL-5 (p = 0.018) and BAFF (p = 0.039). Interleukin-2 was increased in HCV carriers with positive ANA when they were compared with ANA-seronegative carriers (p = 0.044). Interleukins IL-4 and IL-10 were not associated with autoimmunity (P > 0.05). In HCV carriers, IL-2 was correlated with IL-5 (p < 0.0001) and IFN-γ (p = 0.015), and IL-5 with IFN-γ (p = 0.015). We concluded that the serum profile of cytokines in HCV carriers presenting autoimmune markers may be mainly represented by increased IL-2, IL-5 and BAFF.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-06-01T18:34:47Z No. of bitstreams: 1 (46)1-s2.0-S0882401009002022-main.pdf: 219699 bytes, checksum: 067e6f42adc0a4fffc96bac7aeef8618 (MD5)Made available in DSpace on 2012-06-01T18:34:47Z (GMT). No. of bitstreams: 1 (46)1-s2.0-S0882401009002022-main.pdf: 219699 bytes, checksum: 067e6f42adc0a4fffc96bac7aeef8618 (MD5) Previous issue date: 2010-02Elsevierhttp://dx.doi.org/10.1016/j.micpath.2009.12.002reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHepatitis CAutoimmunityCryoglobulinaemiaAutoantibodyCytokineSerum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodiesMicrobial Pathogenesisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(46)1-s2.0-S0882401009002022-main.pdf(46)1-s2.0-S0882401009002022-main.pdfapplication/pdf219699https://repositorio.ufba.br/bitstream/ri/6048/1/%2846%291-s2.0-S0882401009002022-main.pdf067e6f42adc0a4fffc96bac7aeef8618MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6048/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(46)1-s2.0-S0882401009002022-main.pdf.txt(46)1-s2.0-S0882401009002022-main.pdf.txtExtracted texttext/plain24562https://repositorio.ufba.br/bitstream/ri/6048/3/%2846%291-s2.0-S0882401009002022-main.pdf.txt64a5fb6edfc7fd4edebb94f76b4187eeMD53ri/60482022-07-05 14:03:21.307oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:21Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
dc.title.alternative.pt_BR.fl_str_mv Microbial Pathogenesis
title Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
spellingShingle Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
Atta, Ajax Mercês
Hepatitis C
Autoimmunity
Cryoglobulinaemia
Autoantibody
Cytokine
title_short Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
title_full Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
title_fullStr Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
title_full_unstemmed Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
title_sort Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies
author Atta, Ajax Mercês
author_facet Atta, Ajax Mercês
Oliveira, Isabela S.
Sousa, Gabriel Menezes de
Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
author_role author
author2 Oliveira, Isabela S.
Sousa, Gabriel Menezes de
Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Atta, Ajax Mercês
Oliveira, Isabela S.
Sousa, Gabriel Menezes de
Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
Atta, Ajax Mercês
Oliveira, Isabela S.
Sousa, Gabriel Menezes de
Paraná, Raymundo
Atta, Maria Luiza Brito de Sousa
dc.subject.por.fl_str_mv Hepatitis C
Autoimmunity
Cryoglobulinaemia
Autoantibody
Cytokine
topic Hepatitis C
Autoimmunity
Cryoglobulinaemia
Autoantibody
Cytokine
description Trabalho completo: acesso restrito, p. 53–56
publishDate 2010
dc.date.issued.fl_str_mv 2010-02
dc.date.accessioned.fl_str_mv 2012-06-01T18:34:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6048
dc.identifier.issn.none.fl_str_mv 0882-4010
dc.identifier.number.pt_BR.fl_str_mv v. 48, n. 2
identifier_str_mv 0882-4010
v. 48, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/6048
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.micpath.2009.12.002
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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