Frequency of celiac disease and its serological markers in patients with autoimmune hepatitis

• Autor(a) principal: Franca, Rita
• Data de Publicação: 2007
• Outros Autores: Bittencourt, Paulo Lisboa, Freitas, Luiz Antonio Rodrigues de, May, Daniel Simões, Andrade, Carol Ferreira de, Cunha, Liliane Monteiro, Toralles, Maria Betânia Pereira, Paraná, Raymundo, Lyra, Luiz Guilherme, Lyra, André Castro, Santos, Daniel R. Diniz, Silva, Luciana Rodrigues
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UFBA
• Texto Completo: http://repositorio.ufba.br/ri/handle/ri/20486
• topic: Doença celíaca; Hepatite auto-imune; Marcadores sorológicos

Transglutaminase (anti-tTG) and anti-endomysial (AEA) antibodies were reported to occur in patients with autoimmune hepatitis (AIH) as well as in subjects with advanced cirrhosis, but the prevalence of celiac disease (CD) in patients with AIH is either negligible or unknown. The frequency of IgA anti-tTG and IgA AEA was determined in 64 patients (54 females, mean age 19[5-67] years ) with AIH diagnosed according to international criteria. Patients with positive or intermediate results for those antibodies were submitted to duodenal biopsy and HLA-DQ2 or DQ8 typing. Anti-tTG and AEA were detected in 6 (9%) and one patient (1.6%) with AIH, respectively. Positive and borderline results for IgA antitTG were detected, respectively, in two (3%) and four (6%) patients. Only one patient with HLA-DQ2 and IgA antitTG and IgA AEA had CD on duodenal biopsy. Two patients with either positive or borderline results for IgA anti-tTG antibody and HLA-DQ2 had normal histology on duodenal biopsy. IgA anti-tTG antibody and/or AEA were observed in 9% of AIH patients, but CD was confirmed in only one of them. The occurrence of IgA anti-tTG antibody in the other patients could be ascribed to the presence of chronic liver disease or to latent or potential CD.