Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14787 |
Resumo: | Texto completo: acesso restrito. p. 595–600 |
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Silva Júnior, Ademir de JesusBuzzi, Fátima de CamposRomanos, Maria Teresa VillelaWagner, Theodoro MarcelGuimarães, Antônio Fernando de Paula CostaCechinel Filho, ValdirBatista, RonanSilva Júnior, Ademir de JesusBuzzi, Fátima de CamposRomanos, Maria Teresa VillelaWagner, Theodoro MarcelGuimarães, Antônio Fernando de Paula CostaCechinel Filho, ValdirBatista, Ronan2014-04-03T12:02:39Z20130378-8741http://repositorio.ufba.br/ri/handle/ri/14787v. 150, n. 2Texto completo: acesso restrito. p. 595–600Ethnopharmacological relevance: In traditional medicine, teas made from leaves and bark of Gallesia gorazema are used as antispasmodic, anthelmintic, antihemorrhagic and febrifuge agents. Crude leaves of this plant are also employed as a remedy in the treatment of abscesses, orchitis, gonorrhea and for rheumatic pain relief. this study investigates the presumed antinociceptive and anti-inflammatory activities of leaves and roots Gallesia gorazema (Phytolaccaceae) extracts. The most active extract and its isolated compound, a new natural product, are also evaluated against viruses HSV-1 and HSV-2. Materials and methods: In vivo experiments with mice were used to assess the analgesic and anti-inflammatory activities of Gallesia gorazema extracts. Antiviral activity of extracts and the new natural product was investigated by in vitro experiments. Results: Results show that dichloromethanic root (DRE) and ethanolic leaf (ELE) extracts displayed significant antinociceptive and anti-inflammatory activities in in vivo experiments with mice. Both extracts were also assayed against the herpes simplex viruses HSV-1 and HSV-2, but only DRE was highly active, showing a selective antiviral effect against HSV-1. Phytochemical fractionation of DRE led to the isolation of 28-hydroxyoctacosyl ferulate, a novel natural product, which displayed strong antiviral activity against HSV-1 (EC50=21.6 μg/mL) with a selective index above 9, justifying, at least in part, the high selective antiviral activity observed for DRE. Conclusion: These results suggest that the plant Gallesia gorazema is a potential candidate for the development of novel anti-herpetic phytomedicines.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-04-03T12:02:39Z No. of bitstreams: 1 1-s2.0-S0378874113006387-main.pdf: 460031 bytes, checksum: 5a00ebd87c00f46174c17b32c1dd68cb (MD5)Made available in DSpace on 2014-04-03T12:02:39Z (GMT). No. of bitstreams: 1 1-s2.0-S0378874113006387-main.pdf: 460031 bytes, checksum: 5a00ebd87c00f46174c17b32c1dd68cb (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.jep.2013.09.005reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAGallesia gorazemaAntinociceptive and anti-inflammatory activitiesHerpesAntiviral activityAnti-herpetic phytomedicines28-Hydroxyoctacosyl ferulateChemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicinesJournal of Ethnopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0378874113006387-main.pdf1-s2.0-S0378874113006387-main.pdfapplication/pdf460031https://repositorio.ufba.br/bitstream/ri/14787/1/1-s2.0-S0378874113006387-main.pdf5a00ebd87c00f46174c17b32c1dd68cbMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14787/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0378874113006387-main.pdf.txt1-s2.0-S0378874113006387-main.pdf.txtExtracted texttext/plain35016https://repositorio.ufba.br/bitstream/ri/14787/3/1-s2.0-S0378874113006387-main.pdf.txt8930b45bfcdd3a7bdf8310cbb977799cMD53ri/147872022-07-05 14:03:51.274oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Ethnopharmacology |
| title |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| spellingShingle |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines Silva Júnior, Ademir de Jesus Gallesia gorazema Antinociceptive and anti-inflammatory activities Herpes Antiviral activity Anti-herpetic phytomedicines 28-Hydroxyoctacosyl ferulate |
| title_short |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| title_full |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| title_fullStr |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| title_full_unstemmed |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| title_sort |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines |
| author |
Silva Júnior, Ademir de Jesus |
| author_facet |
Silva Júnior, Ademir de Jesus Buzzi, Fátima de Campos Romanos, Maria Teresa Villela Wagner, Theodoro Marcel Guimarães, Antônio Fernando de Paula Costa Cechinel Filho, Valdir Batista, Ronan |
| author_role |
author |
| author2 |
Buzzi, Fátima de Campos Romanos, Maria Teresa Villela Wagner, Theodoro Marcel Guimarães, Antônio Fernando de Paula Costa Cechinel Filho, Valdir Batista, Ronan |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva Júnior, Ademir de Jesus Buzzi, Fátima de Campos Romanos, Maria Teresa Villela Wagner, Theodoro Marcel Guimarães, Antônio Fernando de Paula Costa Cechinel Filho, Valdir Batista, Ronan Silva Júnior, Ademir de Jesus Buzzi, Fátima de Campos Romanos, Maria Teresa Villela Wagner, Theodoro Marcel Guimarães, Antônio Fernando de Paula Costa Cechinel Filho, Valdir Batista, Ronan |
| dc.subject.por.fl_str_mv |
Gallesia gorazema Antinociceptive and anti-inflammatory activities Herpes Antiviral activity Anti-herpetic phytomedicines 28-Hydroxyoctacosyl ferulate |
| topic |
Gallesia gorazema Antinociceptive and anti-inflammatory activities Herpes Antiviral activity Anti-herpetic phytomedicines 28-Hydroxyoctacosyl ferulate |
| description |
Texto completo: acesso restrito. p. 595–600 |
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2013 |
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2013 |
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2014-04-03T12:02:39Z |
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info:eu-repo/semantics/publishedVersion |
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0378-8741 |
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v. 150, n. 2 |
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0378-8741 v. 150, n. 2 |
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http://repositorio.ufba.br/ri/handle/ri/14787 |
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