Pressure response in chagasic cardiomyopathy patients after using sildenafil

Detalhes bibliográficos
Autor(a) principal: Athanazio, Rodrigo Abensur
Data de Publicação: 2007
Outros Autores: Freitas, Daniel Meira, Almeida, Daniela Batista de, Dantas, Nei, Reis, Francisco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6230
Resumo: p.325-328
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spelling Athanazio, Rodrigo AbensurFreitas, Daniel MeiraAlmeida, Daniela Batista deDantas, NeiReis, FranciscoAthanazio, Rodrigo AbensurFreitas, Daniel MeiraAlmeida, Daniela Batista deDantas, NeiReis, Francisco2012-06-26T13:48:50Z2012-06-26T13:48:50Z20070066-782Xhttp://www.repositorio.ufba.br/ri/handle/ri/6230v. 88, n.3p.325-328Objective: To accurately verify the effect of Sildenafil on blood pressure (BP) and heart rate (HR) in individuals with Chagasic myocardiopathy (CMC) and severe systolic ventricular dysfunction (EF<40%) submitted to physical activity. Methods: Twelve men with ejection fractions <40% and CMC confirmed by a serological test were assessed. The sixminute walk test (6MWT) was performed before and after administration of 50 mg of Sildenafil, with a 30 minute interval. Heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure were taken and compared before and after each 6MWT. For statistical analysis purposes, the study was divided into four stages: before the 6MWT and administration of Sildenafil (S1); after the 6MWT but before the administration of Sildenafil (S2); after the administration of Sildenafil but before the 6MWT (S3); and after the administration of Sildenafil and the 6MWT (S4). Results: Participant ages ranged from 47 to 68 years (57.6 ± 6.4). SBP and DBP after the 6MWT and the administration of Sildenafil (S4) were lower than before taking the drug (S2): 134.2 ± 15.1 versus 125.5 ± 14.0 and 88.4 ± 12.4 versus 83.0 ± 10.8, respectively. None of the patients reported any symptoms during the 6MWT. There were no differences in the distances walked during the 6MWT before or after taking Sildenafil (487.5±15.22 versus 505.3±18.45 meters, respectively)–p=0.056, or in HR (before Sildenafil 75.5 ± 8.79 and 96.8 ± 10.36 bpm and after 77.1 ± 9.81 and 96.1 ± 12.97 bpm). Conclusion: A significant reduction in BP after physical activity while using Sildenafil was observed. However, during the six-minute walk test, the patients did not report any symptoms, indicating that this effect is not sufficient to cause clinical manifestations in CMC and heart failure patients.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-06-26T13:48:50Z No. of bitstreams: 1 Athanazio, Rodrigo Abensur.pdf: 154816 bytes, checksum: 4b715718ae6fac230ff4fe41c4ebfb60 (MD5)Made available in DSpace on 2012-06-26T13:48:50Z (GMT). No. of bitstreams: 1 Athanazio, Rodrigo Abensur.pdf: 154816 bytes, checksum: 4b715718ae6fac230ff4fe41c4ebfb60 (MD5) Previous issue date: 2007Rio de JaneiroArquivos Brasileiros de Cardiologiahttp://dx.doi.org/10.1590/S0066-782X2007000300018reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBACardiac outputLowChagas diseaseSildenafilChagas cardiomyopathyPressure response in chagasic cardiomyopathy patients after using sildenafilArq. Bras. 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dc.title.pt_BR.fl_str_mv Pressure response in chagasic cardiomyopathy patients after using sildenafil
dc.title.alternative.pt_BR.fl_str_mv Arq. Bras. Cardiol.
title Pressure response in chagasic cardiomyopathy patients after using sildenafil
spellingShingle Pressure response in chagasic cardiomyopathy patients after using sildenafil
Athanazio, Rodrigo Abensur
Cardiac output
Low
Chagas disease
Sildenafil
Chagas cardiomyopathy
title_short Pressure response in chagasic cardiomyopathy patients after using sildenafil
title_full Pressure response in chagasic cardiomyopathy patients after using sildenafil
title_fullStr Pressure response in chagasic cardiomyopathy patients after using sildenafil
title_full_unstemmed Pressure response in chagasic cardiomyopathy patients after using sildenafil
title_sort Pressure response in chagasic cardiomyopathy patients after using sildenafil
author Athanazio, Rodrigo Abensur
author_facet Athanazio, Rodrigo Abensur
Freitas, Daniel Meira
Almeida, Daniela Batista de
Dantas, Nei
Reis, Francisco
author_role author
author2 Freitas, Daniel Meira
Almeida, Daniela Batista de
Dantas, Nei
Reis, Francisco
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Athanazio, Rodrigo Abensur
Freitas, Daniel Meira
Almeida, Daniela Batista de
Dantas, Nei
Reis, Francisco
Athanazio, Rodrigo Abensur
Freitas, Daniel Meira
Almeida, Daniela Batista de
Dantas, Nei
Reis, Francisco
dc.subject.por.fl_str_mv Cardiac output
Low
Chagas disease
Sildenafil
Chagas cardiomyopathy
topic Cardiac output
Low
Chagas disease
Sildenafil
Chagas cardiomyopathy
description p.325-328
publishDate 2007
dc.date.issued.fl_str_mv 2007
dc.date.accessioned.fl_str_mv 2012-06-26T13:48:50Z
dc.date.available.fl_str_mv 2012-06-26T13:48:50Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6230
dc.identifier.issn.none.fl_str_mv 0066-782X
dc.identifier.number.pt_BR.fl_str_mv v. 88, n.3
identifier_str_mv 0066-782X
v. 88, n.3
url http://www.repositorio.ufba.br/ri/handle/ri/6230
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2007000300018
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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