Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance

Detalhes bibliográficos
Autor(a) principal: Santos, Milena Soares
Data de Publicação: 2009
Outros Autores: Ribeiro, Guilherme de Sousa, Oliveira, Tainara Queiroz, et al.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14031
Resumo: BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.
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spelling Santos, Milena SoaresRibeiro, Guilherme de SousaOliveira, Tainara Queiroz, et al.Santos, Milena SoaresRibeiro, Guilherme de SousaOliveira, Tainara Queiroz, et al.2013-12-02T12:30:30Z2009-071201-9712http://repositorio.ufba.br/ri/handle/ri/14031v.13, n.4, p.456-61.BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2013-12-02T12:30:30Z No. of bitstreams: 1 Guilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdf: 131723 bytes, checksum: 5a25512aa807f0e513f322d1a3cbe199 (MD5)Made available in DSpace on 2013-12-02T12:30:30Z (GMT). No. of bitstreams: 1 Guilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdf: 131723 bytes, checksum: 5a25512aa807f0e513f322d1a3cbe199 (MD5) Previous issue date: 2009-07HamiltonInternational Society for Infectious DiseasesStreptococcus PyogenesGroup A streptococcusMeningitisBurden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillanceInt. J. Infect. Dis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALGuilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdfGuilherme Ribeiro. 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dc.title.pt_BR.fl_str_mv Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
dc.title.alternative.pt_BR.fl_str_mv Int. J. Infect. Dis.
title Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
spellingShingle Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
Santos, Milena Soares
Streptococcus Pyogenes
Group A streptococcus
Meningitis
title_short Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
title_full Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
title_fullStr Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
title_full_unstemmed Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
title_sort Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
author Santos, Milena Soares
author_facet Santos, Milena Soares
Ribeiro, Guilherme de Sousa
Oliveira, Tainara Queiroz, et al.
author_role author
author2 Ribeiro, Guilherme de Sousa
Oliveira, Tainara Queiroz, et al.
author2_role author
author
dc.contributor.author.fl_str_mv Santos, Milena Soares
Ribeiro, Guilherme de Sousa
Oliveira, Tainara Queiroz, et al.
Santos, Milena Soares
Ribeiro, Guilherme de Sousa
Oliveira, Tainara Queiroz, et al.
dc.subject.por.fl_str_mv Streptococcus Pyogenes
Group A streptococcus
Meningitis
topic Streptococcus Pyogenes
Group A streptococcus
Meningitis
description BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.
publishDate 2009
dc.date.issued.fl_str_mv 2009-07
dc.date.accessioned.fl_str_mv 2013-12-02T12:30:30Z
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14031
dc.identifier.issn.none.fl_str_mv 1201-9712
dc.identifier.number.pt_BR.fl_str_mv v.13, n.4, p.456-61.
identifier_str_mv 1201-9712
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dc.publisher.none.fl_str_mv International Society for Infectious Diseases
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