Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14031 |
Resumo: | BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies. |
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Santos, Milena SoaresRibeiro, Guilherme de SousaOliveira, Tainara Queiroz, et al.Santos, Milena SoaresRibeiro, Guilherme de SousaOliveira, Tainara Queiroz, et al.2013-12-02T12:30:30Z2009-071201-9712http://repositorio.ufba.br/ri/handle/ri/14031v.13, n.4, p.456-61.BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2013-12-02T12:30:30Z No. of bitstreams: 1 Guilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdf: 131723 bytes, checksum: 5a25512aa807f0e513f322d1a3cbe199 (MD5)Made available in DSpace on 2013-12-02T12:30:30Z (GMT). No. of bitstreams: 1 Guilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdf: 131723 bytes, checksum: 5a25512aa807f0e513f322d1a3cbe199 (MD5) Previous issue date: 2009-07HamiltonInternational Society for Infectious DiseasesStreptococcus PyogenesGroup A streptococcusMeningitisBurden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillanceInt. J. Infect. Dis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALGuilherme Ribeiro. Burden of group A streptococcal meningitis in Salvador...2009.pdfGuilherme Ribeiro. 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dc.title.pt_BR.fl_str_mv |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
dc.title.alternative.pt_BR.fl_str_mv |
Int. J. Infect. Dis. |
title |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
spellingShingle |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance Santos, Milena Soares Streptococcus Pyogenes Group A streptococcus Meningitis |
title_short |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
title_full |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
title_fullStr |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
title_full_unstemmed |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
title_sort |
Burden of group A streptococcal meningitis in Salvador, Brazil: report of 11 years of population-based surveillance |
author |
Santos, Milena Soares |
author_facet |
Santos, Milena Soares Ribeiro, Guilherme de Sousa Oliveira, Tainara Queiroz, et al. |
author_role |
author |
author2 |
Ribeiro, Guilherme de Sousa Oliveira, Tainara Queiroz, et al. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Santos, Milena Soares Ribeiro, Guilherme de Sousa Oliveira, Tainara Queiroz, et al. Santos, Milena Soares Ribeiro, Guilherme de Sousa Oliveira, Tainara Queiroz, et al. |
dc.subject.por.fl_str_mv |
Streptococcus Pyogenes Group A streptococcus Meningitis |
topic |
Streptococcus Pyogenes Group A streptococcus Meningitis |
description |
BACKGROUND: Over recent decades, a resurgence of invasive group A streptococcal (GAS) infections has been observed; GAS remains a rare cause of pyogenic meningitis. We report herein population-based findings of long-term surveillance for GAS meningitis in Salvador, Brazil, and estimate the overall burden of invasive GAS infections. METHODS: From February 1996 to February 2007 we conducted active surveillance for GAS meningitis in the state reference hospital for infectious diseases in Salvador, Brazil. Data on clinical presentation, laboratory records, and outcome were collected through interviews and chart review. GAS isolates were evaluated for antimicrobial susceptibility and emm type. RESULTS: We identified 20 cases of GAS meningitis, which accounted for 0.9% of all culture-proven bacterial meningitis in the study period. The mean annual incidence of GAS meningitis was 0.03 cases per 100,000 population in metropolitan Salvador and peaked in children <1 year of age (0.67 cases per 100,000 population). Among 17 cases with clinical information available, 41% required intensive care unit support and 25% died. Tested isolates were susceptible to penicillin and exhibited large emm type diversity. Based on the incidence of GAS meningitis, we estimate that the annual incidence of GAS infection is 3 cases per 100,000 population in metropolitan Salvador. CONCLUSIONS: Although rare, GAS is a life-threatening cause of bacterial meningitis. Knowledge of the incidence and emm type variability of the disease is necessary for planning immunization strategies. |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009-07 |
dc.date.accessioned.fl_str_mv |
2013-12-02T12:30:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/14031 |
dc.identifier.issn.none.fl_str_mv |
1201-9712 |
dc.identifier.number.pt_BR.fl_str_mv |
v.13, n.4, p.456-61. |
identifier_str_mv |
1201-9712 v.13, n.4, p.456-61. |
url |
http://repositorio.ufba.br/ri/handle/ri/14031 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
International Society for Infectious Diseases |
publisher.none.fl_str_mv |
International Society for Infectious Diseases |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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Repositório Institucional da UFBA |
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