Antibodies to schistosoma mansoni in human cerebrospinal fluid

Detalhes bibliográficos
Autor(a) principal: Lemaire, Denise Carneiro
Data de Publicação: 2003
Outros Autores: Santos, Isis F. Magalhães, Andrade Filho, Antônio de Souza, Queiroz, Aristides Cheto de, Carvalho, Otavio Augusto Moreno de, Carmo, Theomira Mauadie Azevedo, Siqueira, Isadora C., Andrade, Débora M., Rego, Michely F., Guedes, Ana Paula T., Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16602
Resumo: Texto completo: acesso restrito. p. 294-298
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spelling Lemaire, Denise CarneiroSantos, Isis F. MagalhãesAndrade Filho, Antônio de SouzaQueiroz, Aristides Cheto deCarvalho, Otavio Augusto Moreno deCarmo, Theomira Mauadie AzevedoSiqueira, Isadora C.Andrade, Débora M.Rego, Michely F.Guedes, Ana Paula T.Reis, Mitermayer Galvão dosLemaire, Denise CarneiroSantos, Isis F. MagalhãesAndrade Filho, Antônio de SouzaQueiroz, Aristides Cheto deCarvalho, Otavio Augusto Moreno deCarmo, Theomira Mauadie AzevedoSiqueira, Isadora C.Andrade, Débora M.Rego, Michely F.Guedes, Ana Paula T.Reis, Mitermayer Galvão dos2014-11-14T13:11:02Z20030002-9637http://repositorio.ufba.br/ri/handle/ri/16602v. 68, n. 3Texto completo: acesso restrito. p. 294-298Cerebrospinal fluid (CSF) and serum samples from patients suspected of having neuroschistosomiasis (NS) were evaluated by an enzyme-linked immunosorbent assay. Monoclonal antibodies of various immunoglobulin isotypes (IgM, IgA, IgE, total IgG, IgG1, IgG2, IgG3, and IgG4) were used to detect antibodies against Schistosoma mansoni soluble egg antigen (SEA) and soluble worm adult preparation (SWAP). Of the 83 CSF samples tested, 55% were reactive toSEA (26% were reactive only toSEA and 29% tobo th SEA and SWAP), 34% were reactive toSWAP (5% only to SWAP and 29% to both SEA and SWAP), and 40% were not reactive with any antigen. Cases that tested positive for SWAP in CSF and negative in serum were not found. Samples with high specific IgG antibody titers were selected for immunoglobulin isotype profiling. In the CSF samples, the antibodies against SEA and SWAP were mainly IgM, IgG1, and IgG4, although other immunoglobulins were also detected. Interestingly, nine patients had high levels of IgG1 only in the CSF. These results suggest that there is local synthesis of IgG1, and that this isotype could be an important immunologic marker in the diagnosis of NS.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-13T14:37:09Z No. of bitstreams: 1 DENISE C. LEMAIRE.pdf: 139362 bytes, checksum: 58a12a56c9ec4a974752aea98f4bd8c4 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-14T13:11:02Z (GMT) No. of bitstreams: 1 DENISE C. LEMAIRE.pdf: 139362 bytes, checksum: 58a12a56c9ec4a974752aea98f4bd8c4 (MD5)Made available in DSpace on 2014-11-14T13:11:02Z (GMT). No. of bitstreams: 1 DENISE C. LEMAIRE.pdf: 139362 bytes, checksum: 58a12a56c9ec4a974752aea98f4bd8c4 (MD5) Previous issue date: 2003Schistosoma mansoniImmunoglobulin IsotypesNeuroschistosomiasisAntibodies to schistosoma mansoni in human cerebrospinal fluidAmerican Journal of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAORIGINALDENISE C. LEMAIRE.pdfDENISE C. LEMAIRE.pdfapplication/pdf139362https://repositorio.ufba.br/bitstream/ri/16602/1/DENISE%20C.%20LEMAIRE.pdf58a12a56c9ec4a974752aea98f4bd8c4MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16602/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTDENISE C. LEMAIRE.pdf.txtDENISE C. 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dc.title.pt_BR.fl_str_mv Antibodies to schistosoma mansoni in human cerebrospinal fluid
dc.title.alternative.pt_BR.fl_str_mv American Journal of Tropical Medicine and Hygiene
title Antibodies to schistosoma mansoni in human cerebrospinal fluid
spellingShingle Antibodies to schistosoma mansoni in human cerebrospinal fluid
Lemaire, Denise Carneiro
Schistosoma mansoni
Immunoglobulin Isotypes
Neuroschistosomiasis
title_short Antibodies to schistosoma mansoni in human cerebrospinal fluid
title_full Antibodies to schistosoma mansoni in human cerebrospinal fluid
title_fullStr Antibodies to schistosoma mansoni in human cerebrospinal fluid
title_full_unstemmed Antibodies to schistosoma mansoni in human cerebrospinal fluid
title_sort Antibodies to schistosoma mansoni in human cerebrospinal fluid
author Lemaire, Denise Carneiro
author_facet Lemaire, Denise Carneiro
Santos, Isis F. Magalhães
Andrade Filho, Antônio de Souza
Queiroz, Aristides Cheto de
Carvalho, Otavio Augusto Moreno de
Carmo, Theomira Mauadie Azevedo
Siqueira, Isadora C.
Andrade, Débora M.
Rego, Michely F.
Guedes, Ana Paula T.
Reis, Mitermayer Galvão dos
author_role author
author2 Santos, Isis F. Magalhães
Andrade Filho, Antônio de Souza
Queiroz, Aristides Cheto de
Carvalho, Otavio Augusto Moreno de
Carmo, Theomira Mauadie Azevedo
Siqueira, Isadora C.
Andrade, Débora M.
Rego, Michely F.
Guedes, Ana Paula T.
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lemaire, Denise Carneiro
Santos, Isis F. Magalhães
Andrade Filho, Antônio de Souza
Queiroz, Aristides Cheto de
Carvalho, Otavio Augusto Moreno de
Carmo, Theomira Mauadie Azevedo
Siqueira, Isadora C.
Andrade, Débora M.
Rego, Michely F.
Guedes, Ana Paula T.
Reis, Mitermayer Galvão dos
Lemaire, Denise Carneiro
Santos, Isis F. Magalhães
Andrade Filho, Antônio de Souza
Queiroz, Aristides Cheto de
Carvalho, Otavio Augusto Moreno de
Carmo, Theomira Mauadie Azevedo
Siqueira, Isadora C.
Andrade, Débora M.
Rego, Michely F.
Guedes, Ana Paula T.
Reis, Mitermayer Galvão dos
dc.subject.por.fl_str_mv Schistosoma mansoni
Immunoglobulin Isotypes
Neuroschistosomiasis
topic Schistosoma mansoni
Immunoglobulin Isotypes
Neuroschistosomiasis
description Texto completo: acesso restrito. p. 294-298
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-11-14T13:11:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16602
dc.identifier.issn.none.fl_str_mv 0002-9637
dc.identifier.number.pt_BR.fl_str_mv v. 68, n. 3
identifier_str_mv 0002-9637
v. 68, n. 3
url http://repositorio.ufba.br/ri/handle/ri/16602
dc.language.iso.fl_str_mv eng
language eng
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