Central lead administration inhibits water intake and sodium appetite in rats

Detalhes bibliográficos
Autor(a) principal: Silva, E. J. de Castro e
Data de Publicação: 1999
Outros Autores: Castro, L., Luz, C. P., Ferreira, H., Lima, A. K. S., Souza, F. S. F., Maldonado, I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7973
Resumo: p.1243-1248
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spelling Silva, E. J. de Castro eCastro, L.Luz, C. P.Ferreira, H.Lima, A. K. S.Souza, F. S. F.Maldonado, I.Silva, E. J. de Castro eCastro, L.Luz, C. P.Ferreira, H.Lima, A. K. S.Souza, F. S. F.Maldonado, I.2013-01-18T11:39:15Z2013-01-18T11:39:15Z19990100-879Xhttp://www.repositorio.ufba.br/ri/handle/ri/7973v. 32, n. 10p.1243-1248We have demonstrated that acute third ventricle injections of lead acetate (PbAc) exert a powerful antidipsogenic effect and induce a significant increase in renal sodium excretion. In the present study we confirm the antidipsogenic effect of lead and demonstrate that central administration of this metal, in minute amounts, significantly reduces salt intake both during dehydration and after central angiotensinergic stimulation. Adult male Wistar rats had the third ventricle cannulated seven days before the experiments. During this period they had free access to distilled water and hypertonic saline solution (1.5%). After a 24-h period of fluid deprivation, experimental animals received third ventricle injections of PbAc (0.3, N = 8 and 3.0 nmol/rat, N = 14) while controls received sodium acetate (NaAc; 3.0 nmol/rat, N = 10). Rats treated with PbAc at the highest dose showed a significant reduction (P<0.05) both in water and hypertonic saline intake when compared to controls. When the effect of lead administration on angiotensin II-induced water and salt intake was studied, normohydrated animals received third ventricle injections of angiotensin II (9.6 nmol/rat) after pretreatment with 3.0 nmol/rat of PbAc (experimental group, N = 10) or NaAc (controls, N = 8). The group pretreated with PbAc presented a significant reduction (P<0.05) in both water and salt intake compared to controls. Thus, this study confirms the antidipsogenic effect of central lead injections and demonstrates that the presence of lead in the brain exerts a significant inhibition of sodium appetite.Submitted by Suelen Reis (suelen_suzane@hotmail.com) on 2013-01-18T11:39:15Z No. of bitstreams: 1 Castro e Silva.pdf: 123484 bytes, checksum: 371d022fdd221aab7ec29de9cf432bc0 (MD5)Made available in DSpace on 2013-01-18T11:39:15Z (GMT). No. of bitstreams: 1 Castro e Silva.pdf: 123484 bytes, checksum: 371d022fdd221aab7ec29de9cf432bc0 (MD5) Previous issue date: 1999http://dx.doi.org/10.1590/S0100-879X1999001000011reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeadAngiotensin IIWater intakeSodium intakeRatsCentral lead administration inhibits water intake and sodium appetite in ratsBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/7973/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52ORIGINALCastro e Silva.pdfCastro e Silva.pdfapplication/pdf123484https://repositorio.ufba.br/bitstream/ri/7973/1/Castro%20e%20Silva.pdf371d022fdd221aab7ec29de9cf432bc0MD51TEXTCastro e Silva.pdf.txtCastro e Silva.pdf.txtExtracted texttext/plain21567https://repositorio.ufba.br/bitstream/ri/7973/3/Castro%20e%20Silva.pdf.txt041107e704b15b4cda45c898fc3941ebMD53ri/79732022-07-05 14:04:14.321oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Central lead administration inhibits water intake and sodium appetite in rats
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Central lead administration inhibits water intake and sodium appetite in rats
spellingShingle Central lead administration inhibits water intake and sodium appetite in rats
Silva, E. J. de Castro e
Lead
Angiotensin II
Water intake
Sodium intake
Rats
title_short Central lead administration inhibits water intake and sodium appetite in rats
title_full Central lead administration inhibits water intake and sodium appetite in rats
title_fullStr Central lead administration inhibits water intake and sodium appetite in rats
title_full_unstemmed Central lead administration inhibits water intake and sodium appetite in rats
title_sort Central lead administration inhibits water intake and sodium appetite in rats
author Silva, E. J. de Castro e
author_facet Silva, E. J. de Castro e
Castro, L.
Luz, C. P.
Ferreira, H.
Lima, A. K. S.
Souza, F. S. F.
Maldonado, I.
author_role author
author2 Castro, L.
Luz, C. P.
Ferreira, H.
Lima, A. K. S.
Souza, F. S. F.
Maldonado, I.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, E. J. de Castro e
Castro, L.
Luz, C. P.
Ferreira, H.
Lima, A. K. S.
Souza, F. S. F.
Maldonado, I.
Silva, E. J. de Castro e
Castro, L.
Luz, C. P.
Ferreira, H.
Lima, A. K. S.
Souza, F. S. F.
Maldonado, I.
dc.subject.por.fl_str_mv Lead
Angiotensin II
Water intake
Sodium intake
Rats
topic Lead
Angiotensin II
Water intake
Sodium intake
Rats
description p.1243-1248
publishDate 1999
dc.date.issued.fl_str_mv 1999
dc.date.accessioned.fl_str_mv 2013-01-18T11:39:15Z
dc.date.available.fl_str_mv 2013-01-18T11:39:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7973
dc.identifier.issn.none.fl_str_mv 0100-879X
dc.identifier.number.pt_BR.fl_str_mv v. 32, n. 10
identifier_str_mv 0100-879X
v. 32, n. 10
url http://www.repositorio.ufba.br/ri/handle/ri/7973
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X1999001000011
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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