Prostanoids modulate inflammation and alloimmune responses during graft rejection

Detalhes bibliográficos
Autor(a) principal: Rocha, P. N.
Data de Publicação: 2005
Outros Autores: Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7037
Resumo: p.1759-1768
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spelling Rocha, P. N.Carvalho Filho, Edgar Marcelino deRocha, P. N.Carvalho Filho, Edgar Marcelino de2012-10-23T19:10:43Z2012-10-23T19:10:43Z2005-121414-431Xhttp://www.repositorio.ufba.br/ri/handle/ri/7037v. 38, n. 12p.1759-1768Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief overview of the alloimmune response, of prostanoid biology, and discuss the available evidence for the role of prostaglandin E2 and thromboxane A2 in graft rejection.Submitted by Texeira Ana (atanateixeira@gmail.com) on 2012-10-23T19:10:43Z No. of bitstreams: 1 Rocha, P.N..pdf: 926646 bytes, checksum: 55ae4afd56ba293512ee7269eb32948e (MD5)Made available in DSpace on 2012-10-23T19:10:43Z (GMT). No. of bitstreams: 1 Rocha, P.N..pdf: 926646 bytes, checksum: 55ae4afd56ba293512ee7269eb32948e (MD5) Previous issue date: 2005-12Ribeirão PretoBrazilian Journal of Medical and Biological Researchhttp://dx.doi.org/10.1590/S0100-879X2005001200004reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAThromboxaneProstaglandinsTransplantationInflammationRejectionCorticosteroidsProstanoids modulate inflammation and alloimmune responses during graft rejectionBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINALRocha, P.N..pdfRocha, P.N..pdfapplication/pdf926646https://repositorio.ufba.br/bitstream/ri/7037/1/Rocha%2c%20P.N..pdf55ae4afd56ba293512ee7269eb32948eMD51LICENSElicense.txtlicense.txttext/plain1809https://repositorio.ufba.br/bitstream/ri/7037/2/license.txt8bb3e3eb871f5854a9ec419f68651b60MD52TEXTRocha, P.N..pdf.txtRocha, P.N..pdf.txtExtracted texttext/plain41031https://repositorio.ufba.br/bitstream/ri/7037/3/Rocha%2c%20P.N..pdf.txtebb05e202fad2fa64c16db20bb5f94a5MD53ri/70372022-07-05 14:03:10.915oai:repositorio.ufba.br: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ório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:10Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Prostanoids modulate inflammation and alloimmune responses during graft rejection
dc.title.alternative.pt_BR.fl_str_mv Brazilian Journal of Medical and Biological Research
title Prostanoids modulate inflammation and alloimmune responses during graft rejection
spellingShingle Prostanoids modulate inflammation and alloimmune responses during graft rejection
Rocha, P. N.
Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
title_short Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_full Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_fullStr Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_full_unstemmed Prostanoids modulate inflammation and alloimmune responses during graft rejection
title_sort Prostanoids modulate inflammation and alloimmune responses during graft rejection
author Rocha, P. N.
author_facet Rocha, P. N.
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Carvalho Filho, Edgar Marcelino de
author2_role author
dc.contributor.author.fl_str_mv Rocha, P. N.
Carvalho Filho, Edgar Marcelino de
Rocha, P. N.
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
topic Thromboxane
Prostaglandins
Transplantation
Inflammation
Rejection
Corticosteroids
description p.1759-1768
publishDate 2005
dc.date.issued.fl_str_mv 2005-12
dc.date.accessioned.fl_str_mv 2012-10-23T19:10:43Z
dc.date.available.fl_str_mv 2012-10-23T19:10:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7037
dc.identifier.issn.none.fl_str_mv 1414-431X
dc.identifier.number.pt_BR.fl_str_mv v. 38, n. 12
identifier_str_mv 1414-431X
v. 38, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/7037
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
publisher.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2005001200004
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
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instacron_str UFBA
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reponame_str Repositório Institucional da UFBA
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