High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis

Detalhes bibliográficos
Autor(a) principal: Silbernagel, Günther
Data de Publicação: 2013
Outros Autores: Chapman, M. John, Genser, Bernd, Kleber, Marcus E., Fauler, Günter, Scharnagl, Hubert, Grammer, Tanja B., Boehm, Bernhard O., Mäkelä, Kari-Matti, Kähönen, Mika, Carmena, Rafael, Rietzschel, Ernst R., Bruckert, Eric, Deanfield, John E., Miettinen, Tatu A., Raitakari, Olli T., Lehtimäki, Terho, März, Winfried
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/13281
Resumo: Texto completo. Acesso restrito. p. 291–299
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spelling Silbernagel, GüntherChapman, M. JohnGenser, BerndKleber, Marcus E.Fauler, GünterScharnagl, HubertGrammer, Tanja B.Boehm, Bernhard O.Mäkelä, Kari-MattiKähönen, MikaCarmena, RafaelRietzschel, Ernst R.Bruckert, EricDeanfield, John E.Miettinen, Tatu A.Raitakari, Olli T.Lehtimäki, TerhoMärz, WinfriedSilbernagel, GüntherChapman, M. JohnGenser, BerndKleber, Marcus E.Fauler, GünterScharnagl, HubertGrammer, Tanja B.Boehm, Bernhard O.Mäkelä, Kari-MattiKähönen, MikaCarmena, RafaelRietzschel, Ernst R.Bruckert, EricDeanfield, John E.Miettinen, Tatu A.Raitakari, Olli T.Lehtimäki, TerhoMärz, Winfried2013-10-16T19:00:50Z2013-10-16T19:00:50Z20130735-1097http://www.repositorio.ufba.br/ri/handle/ri/13281v. 62, n. 4Texto completo. Acesso restrito. p. 291–299Objectives This study sought to determine whether high intestinal cholesterol absorption represents a cardiovascular risk factor and to link ABCG8 and ABO variants to cardiovascular disease (CVD). Background Plant sterol–enriched functional foods are widely used for cholesterol lowering. Their regular intake yields a 2-fold increase in circulating plant sterol levels that equally represent markers of cholesterol absorption. Variants in ABCG8 and ABO have been associated with circulating plant sterol levels and CVD, thereby suggesting atherogenic effects of plant sterols or of cholesterol uptake. Methods The cholestanol-to-cholesterol ratio (CR) was used as an estimate of cholesterol absorption because it is independent of plant sterols. First, we investigated the associations of 6 single nucleotide polymorphisms in ABCG8 and ABO with CR in the LURIC (LUdwisghafen RIsk and Cardiovascular health study) and the YFS (Young Finns Study) cohorts. Second, we conducted a systematic review and meta-analysis to investigate whether CR might be related to CVD. Results In LURIC, the minor alleles of rs4245791 and rs4299376 and the major alleles of rs41360247, rs6576629, and rs4953023 of the ABCG8 gene and the minor allele of rs657152 of the ABO gene were significantly associated with higher CR. Consistent results were obtained for rs4245791, rs4299376, rs6576629, and rs4953023 in YFS. The meta-analysis, including 6 studies and 4,362 individuals, found that CR was significantly increased in individuals with CVD. Conclusions High cholesterol absorption is associated with risk alleles in ABCG8 and ABO and with CVD. Harm caused by elevated cholesterol absorption rather than by plant sterols may therefore mediate the relationships of ABCG8 and ABO variants with CVD.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-10-15T20:00:58Z No. of bitstreams: 1 88888888.pdf: 405154 bytes, checksum: cd338eab5840930f5bdbd5095e57df90 (MD5)Approved for entry into archive by Patricia Barroso(pbarroso@ufba.br) on 2013-10-16T19:00:50Z (GMT) No. of bitstreams: 1 88888888.pdf: 405154 bytes, checksum: cd338eab5840930f5bdbd5095e57df90 (MD5)Made available in DSpace on 2013-10-16T19:00:50Z (GMT). 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dc.title.pt_BR.fl_str_mv High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
dc.title.alternative.pt_BR.fl_str_mv Journal of the American College of Cardiology
title High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
spellingShingle High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
Silbernagel, Günther
ABCG8
ABO
Cardiovascular disease
Cholestanol
Intestinal cholesterol absorption
Plant sterols
title_short High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
title_full High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
title_fullStr High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
title_full_unstemmed High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
title_sort High Intestinal Cholesterol Absorption Is Associated With Cardiovascular Disease and Risk Alleles in ABCG8 and ABO : Evidence From the LURIC and YFS Cohorts and From a Meta-Analysis
author Silbernagel, Günther
author_facet Silbernagel, Günther
Chapman, M. John
Genser, Bernd
Kleber, Marcus E.
Fauler, Günter
Scharnagl, Hubert
Grammer, Tanja B.
Boehm, Bernhard O.
Mäkelä, Kari-Matti
Kähönen, Mika
Carmena, Rafael
Rietzschel, Ernst R.
Bruckert, Eric
Deanfield, John E.
Miettinen, Tatu A.
Raitakari, Olli T.
Lehtimäki, Terho
März, Winfried
author_role author
author2 Chapman, M. John
Genser, Bernd
Kleber, Marcus E.
Fauler, Günter
Scharnagl, Hubert
Grammer, Tanja B.
Boehm, Bernhard O.
Mäkelä, Kari-Matti
Kähönen, Mika
Carmena, Rafael
Rietzschel, Ernst R.
Bruckert, Eric
Deanfield, John E.
Miettinen, Tatu A.
Raitakari, Olli T.
Lehtimäki, Terho
März, Winfried
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silbernagel, Günther
Chapman, M. John
Genser, Bernd
Kleber, Marcus E.
Fauler, Günter
Scharnagl, Hubert
Grammer, Tanja B.
Boehm, Bernhard O.
Mäkelä, Kari-Matti
Kähönen, Mika
Carmena, Rafael
Rietzschel, Ernst R.
Bruckert, Eric
Deanfield, John E.
Miettinen, Tatu A.
Raitakari, Olli T.
Lehtimäki, Terho
März, Winfried
Silbernagel, Günther
Chapman, M. John
Genser, Bernd
Kleber, Marcus E.
Fauler, Günter
Scharnagl, Hubert
Grammer, Tanja B.
Boehm, Bernhard O.
Mäkelä, Kari-Matti
Kähönen, Mika
Carmena, Rafael
Rietzschel, Ernst R.
Bruckert, Eric
Deanfield, John E.
Miettinen, Tatu A.
Raitakari, Olli T.
Lehtimäki, Terho
März, Winfried
dc.subject.por.fl_str_mv ABCG8
ABO
Cardiovascular disease
Cholestanol
Intestinal cholesterol absorption
Plant sterols
topic ABCG8
ABO
Cardiovascular disease
Cholestanol
Intestinal cholesterol absorption
Plant sterols
description Texto completo. Acesso restrito. p. 291–299
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-10-16T19:00:50Z
dc.date.available.fl_str_mv 2013-10-16T19:00:50Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/13281
dc.identifier.issn.none.fl_str_mv 0735-1097
dc.identifier.number.pt_BR.fl_str_mv v. 62, n. 4
identifier_str_mv 0735-1097
v. 62, n. 4
url http://www.repositorio.ufba.br/ri/handle/ri/13281
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Journal of the American College of Cardiology
publisher.none.fl_str_mv Journal of the American College of Cardiology
dc.source.pt_BR.fl_str_mv http://www.sciencedirect.com/science/article/pii/S0735109713019815
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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