Distribution of hepatitis B virus genotypes among patients with chronic infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2006 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/12401 |
Resumo: | Texto completo: acesso restrito. p.636–642 |
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Campos, Gubio SoaresAngelo, Ana Luiza DiasRibeiro, Nadia Regina CaldasBraga, Eduardo LorensSantana, Nelma Pereira deGomes, Michele Mesquita SoaresPinho, João Renato RebelloCarvalho, Wilson Andrade deLyra, Luiz Guilherme CostaLyra, André CastroCampos, Gubio SoaresAngelo, Ana Luiza DiasRibeiro, Nadia Regina CaldasBraga, Eduardo LorensSantana, Nelma Pereira deGomes, Michele Mesquita SoaresPinho, João Renato RebelloCarvalho, Wilson Andrade deLyra, Luiz Guilherme CostaLyra, André Castro2013-08-01T17:57:44Z20061478-3223http://www.repositorio.ufba.br/ri/handle/ri/12401v. 26 n.6Texto completo: acesso restrito. p.636–642Abstract: Hepatitis B virus (HBV) can be classified into at least eight genotypes, A–H. We evaluated the distribution HBV genotypes among patients with chronic infection. Methods: We consecutively evaluated adult patients with chronic HBV infection from Salvador, Brazil. Patients were classified according to HBV infection chronic phases based on HBV-DNA levels and presence of serum HBV markers. HBV-DNA was qualitatively and quantitatively detected in serum by polymerised chain reaction (PCR). Isolates were genotyped by comparison of amino acid mutations and phylogenetic analysis. Results: One-hundred and fourteen patients were evaluated. HBV-DNA was positive in 96 samples. HBV genotype was done in 76. Mean age was 36±11.3. In 61 of 76 cases subjects were classified as inactive HBsAg carriers. Their mean HBV serum level was 1760 copies/ml and 53 of 61 were infected with HBV genotype A, seven with HBV genotype F and one with genotype B. Twelve of the 76 patients had detectable hepatitis B e-antigen (HBeAg) in serum. Ten were infected with HBV genotype A and two with genotype F; most had increased alanine aminotransferase and high HBV-DNA levels. Three patients were in the immunotolerant phase, two were infected with HBV genotype A and one with genotype F. HBV subtyping showed subtypes adw2 and adw4. Conclusions: HBV genotype A adw2 and genotype F adw4 were the most prevalent isolates found. We could not find differences in genotype distribution according to HBV clinical phases and DNA levels. We did not detect HBV genotype D in contrast to a previous study in our center with acute hepatitis B. All inactive HBsAg carriers had low HBV-DNA levels.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-08-01T17:57:44Z No. of bitstreams: 1 j.1478-3231.2006.01280.x.pdf: 866168 bytes, checksum: 1e7290b4fe2088d0694be33e7733dc70 (MD5)Made available in DSpace on 2013-08-01T17:57:44Z (GMT). No. of bitstreams: 1 j.1478-3231.2006.01280.x.pdf: 866168 bytes, checksum: 1e7290b4fe2088d0694be33e7733dc70 (MD5) Previous issue date: 2006http://dx.doi.org/ 10.1111/j.1478-3231.2006.01280.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAChronic hepatitis BHBV genotypeHepatitis B virusInactive chronic carriersOrthohepadnavirusDistribution of hepatitis B virus genotypes among patients with chronic infectionLiver Internationalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINALj.1478-3231.2006.01280.x.pdfj.1478-3231.2006.01280.x.pdfapplication/pdf866168https://repositorio.ufba.br/bitstream/ri/12401/1/j.1478-3231.2006.01280.x.pdf1e7290b4fe2088d0694be33e7733dc70MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12401/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXTj.1478-3231.2006.01280.x.pdf.txtj.1478-3231.2006.01280.x.pdf.txtExtracted texttext/plain24325https://repositorio.ufba.br/bitstream/ri/12401/3/j.1478-3231.2006.01280.x.pdf.txte30581a2b69a6b55fdc0f0c7fe0618fcMD53ri/124012022-08-08 13:17:41.144oai:repositorio.ufba.br:ri/12401VGVybW8gZGUgTGljZW7vv71hLCBu77+9byBleGNsdXNpdm8sIHBhcmEgbyBkZXDvv71zaXRvIG5vIHJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVRkJBCgogICAgUGVsbyBwcm9jZXNzbyBkZSBzdWJtaXNz77+9byBkZSBkb2N1bWVudG9zLCBvIGF1dG9yIG91IHNldQpyZXByZXNlbnRhbnRlIGxlZ2FsLCBhbyBhY2VpdGFyIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBjb25jZWRlIGFvClJlcG9zaXTvv71yaW8gSW5zdGl0dWNpb25hbCBkYSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkYSBCYWhpYSBvIGRpcmVpdG8KZGUgbWFudGVyIHVtYSBj77+9cGlhIGVtIHNldSByZXBvc2l077+9cmlvIGNvbSBhIGZpbmFsaWRhZGUsIHByaW1laXJhLCAKZGUgcHJlc2VydmHvv73vv71vLiBFc3NlcyB0ZXJtb3MsIG7vv71vIGV4Y2x1c2l2b3MsIG1hbnTvv71tIG9zIGRpcmVpdG9zIGRlIAphdXRvci9jb3B5cmlnaHQsIG1hcyBlbnRlbmRlIG8gZG9jdW1lbnRvIGNvbW8gcGFydGUgZG8gYWNlcnZvIGludGVsZWN0dWFsIGRlc3NhIFVuaXZlcnNpZGFkZS4gCgogICAgUGFyYSBvcyBkb2N1bWVudG9zIHB1YmxpY2Fkb3MgY29tIHJlcGFzc2UgZGUgZGlyZWl0b3MgZGUgZGlzdHJpYnVp77+977+9bywgZXNzZSB0ZXJtbyBkZSBsaWNlbu+/vWEgZW50ZW5kZSBxdWU6IAoKICAgIE1hbnRlbmRvIG9zICBkaXJlaXRvcyBhdXRvcmFpcywgcmVwYXNzYWRvcyBhIHRlcmNlaXJvcywgZW0gY2FzbyAKZGUgcHVibGljYe+/ve+/vWVzLCBvIHJlcG9zaXTvv71yaW8gcG9kZSByZXN0cmluZ2lyIG8gYWNlc3NvIGFvIHRleHRvIAppbnRlZ3JhbCwgbWFzIGxpYmVyYSBhcyBpbmZvcm1h77+977+9ZXMgc29icmUgbyBkb2N1bWVudG8gKE1ldGFkYWRvcyBkZXNjcml0aXZvcykuCgogRGVzdGEgZm9ybWEsIGF0ZW5kZW5kbyBhb3MgYW5zZWlvcyBkZXNzYSB1bml2ZXJzaWRhZGUgCmVtIG1hbnRlciBzdWEgcHJvZHXvv73vv71vIGNpZW5077+9ZmljYSBjb20gYXMgcmVzdHJp77+977+9ZXMgaW1wb3N0YXMgcGVsb3MgCmVkaXRvcmVzIGRlIHBlcmnvv71kaWNvcy4gCgogICAgUGFyYSBhcyBwdWJsaWNh77+977+9ZXMgZW0gaW5pY2lhdGl2YXMgcXVlIHNlZ3VlbSBhIHBvbO+/vXRpY2EgZGUgCkFjZXNzbyBBYmVydG8sIG9zIGRlcO+/vXNpdG9zIGNvbXB1bHPvv71yaW9zIG5lc3NlIHJlcG9zaXTvv71yaW8gbWFudO+/vW0gCm9zIGRpcmVpdG9zIGF1dG9yYWlzLCBtYXMgbWFudO+/vW0gbyBhY2Vzc28gaXJyZXN0cml0byBhbyBtZXRhZGFkb3MgCmUgdGV4dG8gY29tcGxldG8uIEFzc2ltLCBhIGFjZWl0Ye+/ve+/vW8gZGVzc2UgdGVybW8gbu+/vW8gbmVjZXNzaXRhIGRlIApjb25zZW50aW1lbnRvIHBvciBwYXJ0ZSBkZSBhdXRvcmVzL2RldGVudG9yZXMgZG9zIGRpcmVpdG9zLCBwb3IgCmVzdGFyZW0gZW0gaW5pY2lhdGl2YXMgZGUgYWNlc3NvIGFiZXJ0by4KCiAgICBFbSBhbWJvcyBvIGNhc28sIGVzc2UgdGVybW8gZGUgbGljZW7vv71hLCBwb2RlIHNlciBhY2VpdG8gcGVsbyAKYXV0b3IsIGRldGVudG9yZXMgZGUgZGlyZWl0b3MgZS9vdSB0ZXJjZWlyb3MgYW1wYXJhZG9zIHBlbGEgCnVuaXZlcnNpZGFkZS4gRGV2aWRvIGFvcyBkaWZlcmVudGVzIHByb2Nlc3NvcyBwZWxvIHF1YWwgYSBzdWJtaXNz77+9byAKcG9kZSBvY29ycmVyLCBvIHJlcG9zaXTvv71yaW8gcGVybWl0ZSBhIGFjZWl0Ye+/ve+/vW8gZGEgbGljZW7vv71hIHBvciAKdGVyY2Vpcm9zLCBzb21lbnRlIG5vcyBjYXNvcyBkZSBkb2N1bWVudG9zIHByb2R1emlkb3MgcG9yIGludGVncmFudGVzIApkYSBVRkJBIGUgc3VibWV0aWRvcyBwb3IgcGVzc29hcyBhbXBhcmFkYXMgcG9yIGVzdGEgaW5zdGl0dWnvv73vv71vLgo=Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:41Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| dc.title.alternative.pt_BR.fl_str_mv |
Liver International |
| title |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| spellingShingle |
Distribution of hepatitis B virus genotypes among patients with chronic infection Campos, Gubio Soares Chronic hepatitis B HBV genotype Hepatitis B virus Inactive chronic carriers Orthohepadnavirus |
| title_short |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| title_full |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| title_fullStr |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| title_full_unstemmed |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| title_sort |
Distribution of hepatitis B virus genotypes among patients with chronic infection |
| author |
Campos, Gubio Soares |
| author_facet |
Campos, Gubio Soares Angelo, Ana Luiza Dias Ribeiro, Nadia Regina Caldas Braga, Eduardo Lorens Santana, Nelma Pereira de Gomes, Michele Mesquita Soares Pinho, João Renato Rebello Carvalho, Wilson Andrade de Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author_role |
author |
| author2 |
Angelo, Ana Luiza Dias Ribeiro, Nadia Regina Caldas Braga, Eduardo Lorens Santana, Nelma Pereira de Gomes, Michele Mesquita Soares Pinho, João Renato Rebello Carvalho, Wilson Andrade de Lyra, Luiz Guilherme Costa Lyra, André Castro |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Campos, Gubio Soares Angelo, Ana Luiza Dias Ribeiro, Nadia Regina Caldas Braga, Eduardo Lorens Santana, Nelma Pereira de Gomes, Michele Mesquita Soares Pinho, João Renato Rebello Carvalho, Wilson Andrade de Lyra, Luiz Guilherme Costa Lyra, André Castro Campos, Gubio Soares Angelo, Ana Luiza Dias Ribeiro, Nadia Regina Caldas Braga, Eduardo Lorens Santana, Nelma Pereira de Gomes, Michele Mesquita Soares Pinho, João Renato Rebello Carvalho, Wilson Andrade de Lyra, Luiz Guilherme Costa Lyra, André Castro |
| dc.subject.por.fl_str_mv |
Chronic hepatitis B HBV genotype Hepatitis B virus Inactive chronic carriers Orthohepadnavirus |
| topic |
Chronic hepatitis B HBV genotype Hepatitis B virus Inactive chronic carriers Orthohepadnavirus |
| description |
Texto completo: acesso restrito. p.636–642 |
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2006 |
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2006 |
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2013-08-01T17:57:44Z |
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1478-3223 |
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v. 26 n.6 |
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