Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital

Detalhes bibliográficos
Autor(a) principal: Kaur, Narinder
Data de Publicação: 2009
Outros Autores: Chaudhary, Uma, Aggarwal, Ritu, Bala, Kiran
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/20566
Resumo: Keywords: VRE – HLAR – Quinpristin/Dalfopristin.
id UFBA-2_625e22c5b3ba67fb1d955289e3ff9d51
oai_identifier_str oai:repositorio.ufba.br:ri/20566
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Kaur, NarinderChaudhary, UmaAggarwal, RituBala, KiranKaur, NarinderChaudhary, UmaAggarwal, RituBala, Kiran2016-09-15T17:33:08Z2016-09-15T17:33:08Z2009-01KAUR, N. et al. Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital. R. Ci. méd. biol., Salvador, v.8, n.1, p.26-32, jan./abr. 2009.2236-5222http://repositorio.ufba.br/ri/handle/ri/20566v.8, n.1Keywords: VRE – HLAR – Quinpristin/Dalfopristin.Abstract: During the last few years enterococci have emerged as an important cause of nosocomial and community acquired infection. They have acquired resistance to commonly used antibiotics including glycopeptides posing challenge to therapeutic options. The aim of this study was to investigate the prevalence and sensitivity of VRE to newer drugs. A total of 250 strains of E. faecalis were isolated using conventional scheme of Facklam and Collins. High level aminoglycoside resistance (HLAR) was detected by disc diffusion method using 120 μg gentamicin disc and confirmed by agar dilution screen method. Screening for vancomycin resistance was done by disc diffusion and the agar screen method, and was further confirmed by broth dilution method for minimum inhibitory concentration (MIC). The strains which were resistant to vancomycin were further tested for sensitivity to newer and commonly available antibiotics. Maximum number of enterococcal isolates were recovered from urine (32.8%) followed by blood (25.6%) and pus (18.4%). Penicillin (83.6%) and cotrimoxazole (77.9%) were found to be least effective drugs against the E. faecalis whereas; cefuroxime (76.8%) and vancomycin (98%) were most effective drugs in vitro. About two percent isolates of enterococci were resistant to vancomycin. All the VRE isolates were sensitive to quinupristin/dalfopristin. Linezolid and chloramphenicols were the two other in vitro effective drugs with 80% sensitive isolates. MIC of all the VRE isolates was found to be in range of 64-512μg/mL. So, quinupristin/dalfopristin can be used for infections caused by VRE. Continuous surveillance is necessary to detect early outbreak, and spread of VRE.Abstract During the last few years enterococci have emerged as an important cause of nosocomial and community acquired infection. They have acquired resistance to commonly used antibiotics including glycopeptides posing challenge to therapeutic options. The aim of this study was to investigate the prevalence and sensitivity of VRE to newer drugs. A total of 250 strains of E. faecalis were isolated using conventional scheme of Facklam and Collins. High level aminoglycoside resistance (HLAR) was detected by disc diffusion method using 120 μg gentamicin disc and confirmed by agar dilution screen method. Screening for vancomycin resistance was done by disc diffusion and the agar screen method, and was further confirmed by broth dilution method for minimum inhibitory concentration (MIC). The strains which were resistant to vancomycin were further tested for sensitivity to newer and commonly available antibiotics. Maximum number of enterococcal isolates were recovered from urine (32.8%) followed by blood (25.6%) and pus (18.4%). Penicillin (83.6%) and cotrimoxazole (77.9%) were found to be least effective drugs against the E. faecalis whereas; cefuroxime (76.8%) and vancomycin (98%) were most effective drugs in vitro. About two percent isolates of enterococci were resistant to vancomycin. All the VRE isolates were sensitive to quinupristin/dalfopristin. Linezolid and chloramphenicols were the two other in vitro effective drugs with 80% sensitive isolates. MIC of all the VRE isolates was found to be in range of 64-512μg/mL. So, quinupristin/dalfopristin can be used for infections caused by VRE. Continuous surveillance is necessary to detect early outbreak, and spread of VRE.Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2016-09-15T17:33:08Z No. of bitstreams: 1 4_v.8_1.pdf: 123228 bytes, checksum: 3d3f30c7a8434b2e4dbb2eb114a43cb7 (MD5)Made available in DSpace on 2016-09-15T17:33:08Z (GMT). No. of bitstreams: 1 4_v.8_1.pdf: 123228 bytes, checksum: 3d3f30c7a8434b2e4dbb2eb114a43cb7 (MD5) Previous issue date: 2009-01SalvadorInstituto de Ciências da Saúde/ Universidade Federal da BahiaBrasilhttp://www.portalseer.ufba.br/index.php/cmbio/article/view/4372/3196reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEnterococos Resistentes à VancomicinaAlto Nível de Resistência a AminoglicosídicosQuinupristinaDalfopristinaEmergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospitalRevista de Ciências Médicas e Biológicasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessporORIGINAL4_v.8_1.pdf4_v.8_1.pdfapplication/pdf123228https://repositorio.ufba.br/bitstream/ri/20566/1/4_v.8_1.pdf3d3f30c7a8434b2e4dbb2eb114a43cb7MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/20566/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT4_v.8_1.pdf.txt4_v.8_1.pdf.txtExtracted texttext/plain22749https://repositorio.ufba.br/bitstream/ri/20566/3/4_v.8_1.pdf.txt54e739f4607d45c8c39c297365ac5ba6MD53ri/205662022-07-05 14:03:52.816oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
dc.title.alternative.pt_BR.fl_str_mv Revista de Ciências Médicas e Biológicas
title Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
spellingShingle Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
Kaur, Narinder
Enterococos Resistentes à Vancomicina
Alto Nível de Resistência a Aminoglicosídicos
Quinupristina
Dalfopristina
title_short Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
title_full Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
title_fullStr Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
title_full_unstemmed Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
title_sort Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital
author Kaur, Narinder
author_facet Kaur, Narinder
Chaudhary, Uma
Aggarwal, Ritu
Bala, Kiran
author_role author
author2 Chaudhary, Uma
Aggarwal, Ritu
Bala, Kiran
author2_role author
author
author
dc.contributor.author.fl_str_mv Kaur, Narinder
Chaudhary, Uma
Aggarwal, Ritu
Bala, Kiran
Kaur, Narinder
Chaudhary, Uma
Aggarwal, Ritu
Bala, Kiran
dc.subject.por.fl_str_mv Enterococos Resistentes à Vancomicina
Alto Nível de Resistência a Aminoglicosídicos
Quinupristina
Dalfopristina
topic Enterococos Resistentes à Vancomicina
Alto Nível de Resistência a Aminoglicosídicos
Quinupristina
Dalfopristina
description Keywords: VRE – HLAR – Quinpristin/Dalfopristin.
publishDate 2009
dc.date.issued.fl_str_mv 2009-01
dc.date.accessioned.fl_str_mv 2016-09-15T17:33:08Z
dc.date.available.fl_str_mv 2016-09-15T17:33:08Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv KAUR, N. et al. Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital. R. Ci. méd. biol., Salvador, v.8, n.1, p.26-32, jan./abr. 2009.
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/20566
dc.identifier.issn.none.fl_str_mv 2236-5222
dc.identifier.number.pt_BR.fl_str_mv v.8, n.1
identifier_str_mv KAUR, N. et al. Emergence of VRE and their antimicrobial sensitivity pattern in a tertiary care teaching hospital. R. Ci. méd. biol., Salvador, v.8, n.1, p.26-32, jan./abr. 2009.
2236-5222
v.8, n.1
url http://repositorio.ufba.br/ri/handle/ri/20566
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.publisher.country.fl_str_mv Brasil
publisher.none.fl_str_mv Instituto de Ciências da Saúde/ Universidade Federal da Bahia
dc.source.pt_BR.fl_str_mv http://www.portalseer.ufba.br/index.php/cmbio/article/view/4372/3196
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/20566/1/4_v.8_1.pdf
https://repositorio.ufba.br/bitstream/ri/20566/2/license.txt
https://repositorio.ufba.br/bitstream/ri/20566/3/4_v.8_1.pdf.txt
bitstream.checksum.fl_str_mv 3d3f30c7a8434b2e4dbb2eb114a43cb7
ff6eaa8b858ea317fded99f125f5fcd0
54e739f4607d45c8c39c297365ac5ba6
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1808459508528185344

Registros relacionados