Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study

Detalhes bibliográficos
Autor(a) principal: Reis, Joice N.
Data de Publicação: 2011
Outros Autores: Gouveia, Edilane L., Flannery, Brendan, Cordeiro, Soraia Machado, Lima, Josilene B. T., Pinheiro, Ricardo M., Salgado, Kátia, Mascarenhas, Ana Veronica, Carvalho, M. Gloria, Beall, Bernard W., Reis, Mitermayer Galvão dos, Ko, Albert I.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16470
Resumo: p. 1-10
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spelling Reis, Joice N.Gouveia, Edilane L.Flannery, BrendanCordeiro, Soraia MachadoLima, Josilene B. T.Pinheiro, Ricardo M.Salgado, KátiaMascarenhas, Ana VeronicaCarvalho, M. GloriaBeall, Bernard W.Reis, Mitermayer Galvão dosKo, Albert I.2014-10-27T22:11:39Z2014-10-27T22:11:39Z20111471-2334http://repositorio.ufba.br/ri/handle/ri/16470v. 11p. 1-10Background Prior to the availability of generic third-generation cephalosporins, penicillins were widely used for treatment of pneumococcal meningitis in developing countries despite concerns about rising levels of penicillin resistance among pneumococcal isolates. We examined the impact of penicillin resistance on outcomes of pneumococcal meningitis over a ten year period in an infectious diseases hospital in Brazil. Methods Clinical presentation, antimicrobial therapy and outcomes were reviewed for 548 patients with culture-confirmed pneumococcal meningitis from December, 1995, to November, 2005. Pneumococcal isolates from meningitis patients were defined as penicillin-resistant if Minimum Inhibitory Concentrations for penicillin were greater than 0.06 μg/ml. Proportional hazards regression was used to identify risk factors for fatal outcomes. Results During the ten-year period, ceftriaxone replaced ampicillin as first-line therapy for suspected bacterial meningitis. In hospital case-fatality for pneumococcal meningitis was 37%. Of 548 pneumococcal isolates from meningitis cases, 92 (17%) were resistant to penicillin. After controlling for age and severity of disease at admission, penicillin resistance was associated with higher case-fatality (Hazard Ratio [HR], 1.62; 95% Confidence Interval [CI], 1.08-2.43). Penicillin-resistance remained associated with higher case-fatality when initial therapy included ceftriaxone (HR, 1.68; 95% CI 1.02-2.76).Conclusions Findings support the use of third generation cephalosporin antibiotics for treatment of suspected pneumococcal meningitis even at low prevalence of pneumococcal resistance to penicillins.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-03-13T17:05:35Z No. of bitstreams: 1 Joice N Reis.pdf: 311556 bytes, checksum: 9b9f98dfa45e22745a368f37ee7276ec (MD5)Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-10-27T22:11:39Z (GMT) No. of bitstreams: 1 Joice N Reis.pdf: 311556 bytes, checksum: 9b9f98dfa45e22745a368f37ee7276ec (MD5)Made available in DSpace on 2014-10-27T22:11:39Z (GMT). No. of bitstreams: 1 Joice N Reis.pdf: 311556 bytes, checksum: 9b9f98dfa45e22745a368f37ee7276ec (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1186/1471-2334-11-323reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAClinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational studyBMC Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrasilinfo:eu-repo/semantics/openAccessengORIGINALJoice N Reis.pdfJoice N Reis.pdfapplication/pdf311556https://repositorio.ufba.br/bitstream/ri/16470/1/Joice%20N%20Reis.pdf9b9f98dfa45e22745a368f37ee7276ecMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16470/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTJoice N Reis.pdf.txtJoice N Reis.pdf.txtExtracted texttext/plain51189https://repositorio.ufba.br/bitstream/ri/16470/3/Joice%20N%20Reis.pdf.txtc63fbc8c943cc7903785636fd0b3c770MD53ri/164702022-03-23 20:27:56.116oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-23T23:27:56Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
dc.title.alternative.pt_BR.fl_str_mv BMC Infectious Diseases
title Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
spellingShingle Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
Reis, Joice N.
title_short Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
title_full Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
title_fullStr Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
title_full_unstemmed Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
title_sort Clinical outcome of pneumococcal meningitis during the emergence of pencillin-resistant Streptococcus pneumoniae: an observational study
author Reis, Joice N.
author_facet Reis, Joice N.
Gouveia, Edilane L.
Flannery, Brendan
Cordeiro, Soraia Machado
Lima, Josilene B. T.
Pinheiro, Ricardo M.
Salgado, Kátia
Mascarenhas, Ana Veronica
Carvalho, M. Gloria
Beall, Bernard W.
Reis, Mitermayer Galvão dos
Ko, Albert I.
author_role author
author2 Gouveia, Edilane L.
Flannery, Brendan
Cordeiro, Soraia Machado
Lima, Josilene B. T.
Pinheiro, Ricardo M.
Salgado, Kátia
Mascarenhas, Ana Veronica
Carvalho, M. Gloria
Beall, Bernard W.
Reis, Mitermayer Galvão dos
Ko, Albert I.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Joice N.
Gouveia, Edilane L.
Flannery, Brendan
Cordeiro, Soraia Machado
Lima, Josilene B. T.
Pinheiro, Ricardo M.
Salgado, Kátia
Mascarenhas, Ana Veronica
Carvalho, M. Gloria
Beall, Bernard W.
Reis, Mitermayer Galvão dos
Ko, Albert I.
description p. 1-10
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-10-27T22:11:39Z
dc.date.available.fl_str_mv 2014-10-27T22:11:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16470
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.number.pt_BR.fl_str_mv v. 11
identifier_str_mv 1471-2334
v. 11
url http://repositorio.ufba.br/ri/handle/ri/16470
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.country.fl_str_mv Brasil
dc.source.pt_BR.fl_str_mv http://dx.doi.org/ 10.1186/1471-2334-11-323
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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