Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/17522 |
Resumo: | Texto completo: acesso restrito. p. 70-73 |
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Oliveira, Luiz Fabiano BorgesBáfica, Andre Luiz BarbosaRosato, Andréa BomuraFavali, Cecilia Beatriz FiuzaCosta, Jackson Mauricio LopesCafé, VirginiaBarral-Netto, ManoelBarral, Aldina Maria PradoOliveira, Luiz Fabiano BorgesBáfica, Andre Luiz BarbosaRosato, Andréa BomuraFavali, Cecilia Beatriz FiuzaCosta, Jackson Mauricio LopesCafé, VirginiaBarral-Netto, ManoelBarral, Aldina Maria Prado2015-05-04T15:16:01Z20110002-9637http://repositorio.ufba.br/ri/handle/ri/17522v. 85, n. 1Texto completo: acesso restrito. p. 70-73Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time (P = 0.029), age (P = 0.002), and TNF levels (P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-15T13:37:08Z No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-05-04T15:16:01Z (GMT) No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5)Made available in DSpace on 2015-05-04T15:16:01Z (GMT). No. of bitstreams: 1 Fabiano Oliveira.pdf: 482368 bytes, checksum: e0d829c00156196053624ac79a76f2b8 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.4269/ajtmh.2011.10-0680reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBALeishmaniaCytokinesLymphotoxin-alphaLesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous LeishmaniasisAmerican Journal of Tropical Medicine and Hygieneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01Brasilinfo:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/17522/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALFabiano Oliveira.pdfFabiano Oliveira.pdfapplication/pdf482368https://repositorio.ufba.br/bitstream/ri/17522/1/Fabiano%20Oliveira.pdfe0d829c00156196053624ac79a76f2b8MD51TEXTFabiano Oliveira.pdf.txtFabiano Oliveira.pdf.txtExtracted texttext/plain22316https://repositorio.ufba.br/bitstream/ri/17522/3/Fabiano%20Oliveira.pdf.txtfd5e0ac7dd75791066b58e7fa100a745MD53ri/175222022-07-05 14:05:18.243oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:05:18Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| dc.title.alternative.pt_BR.fl_str_mv |
American Journal of Tropical Medicine and Hygiene |
| title |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| spellingShingle |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis Oliveira, Luiz Fabiano Borges Leishmania Cytokines Lymphotoxin-alpha |
| title_short |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| title_full |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| title_fullStr |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| title_full_unstemmed |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| title_sort |
Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
| author |
Oliveira, Luiz Fabiano Borges |
| author_facet |
Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
| author_role |
author |
| author2 |
Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
| dc.subject.por.fl_str_mv |
Leishmania Cytokines Lymphotoxin-alpha |
| topic |
Leishmania Cytokines Lymphotoxin-alpha |
| description |
Texto completo: acesso restrito. p. 70-73 |
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2011 |
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2011 |
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2015-05-04T15:16:01Z |
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0002-9637 |
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v. 85, n. 1 |
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0002-9637 v. 85, n. 1 |
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