Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers
| Main Author: | |
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| Publication Date: | 2012 |
| Other Authors: | , , , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da UFBA |
| Download full: | http://www.repositorio.ufba.br/ri/handle/ri/5383 |
Summary: | Acesso restrito: texto completo. p. 751-763 |
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Lima, Alessandra Estrela da SilvaAraújo, Márcio Sobreira SilvaCosta Neto, João Moreira daRibeiro, LorenaDamasceno, Karine AraújoD'Assis, Mário Jorge Melhor HeineMartins Filho, Olindo AssisTeixeira-Carvalho, AndréaSerakides, RogériaCassali, Geovanni DantasLima, Alessandra Estrela da SilvaAraújo, Márcio Sobreira SilvaCosta Neto, João Moreira daRibeiro, LorenaDamasceno, Karine AraújoD'Assis, Mário Jorge Melhor HeineMartins Filho, Olindo AssisTeixeira-Carvalho, AndréaSerakides, RogériaCassali, Geovanni Dantas2012-02-10T17:46:05Z20121573-7217http://www.repositorio.ufba.br/ri/handle/ri/5383v. 131Acesso restrito: texto completo. p. 751-763We have evaluated the phenotypic features of peripheral blood leukocytes as putative novel biomarkers with prognostic values to monitor canine mammary carcinomas. Female dogs were categorized into distinct groups, referred as mammary carcinoma in benign mixed tumor- MC-BMT and mammary carcinoma-MC. Our findings demonstrate that decreased percentage of B-cells along with increased frequency of NK-cells, CD8?T-cells, and CD8?CD5Low?T-cells beside higher T/B-cells and lower CD4?/CD8? ratio were the hallmarks of MC-BMT. Despite the lower expression of MHCI and MHCII, the lymphocytes from MC-BMT and MC displayed higher migration potential as suggested by enhanced frequency of CD18? events. Although increased levels of macrophagelike cells/(CD14?CD16?) and decreased levels of MHCII expression were a common phenotypic feature in mammary carcinoma, down-regulation of MHCI was selectively observed in MC. Decreased frequency of CD4? T-cells with increased levels of CD8? T-cells and lower CD4?/ CD8? T-cell ratio were relevant biomarkers of MCBTM(-). Although decreased expression of MHCI by monocytes was observed in MC-BTM regardless of the presence of lymph node metastasis, this phenotypic feature was restricted to MC free of metastasis. The CD4?/CD8? T-cells ratio lower than 1.8 was elected as a valid parameter with outstanding performance to predict survival in MC-BMT. On the other hand, the MHCI expression by monocytes higher than 102 MFI showed good value to estimate worse outcome in MC. These results should help to improve our understanding of the immunological heterogeneity of canine mammary carcinomas and provide tools for the determination of cut-off scores of clinically relevant immonophenotypic prognostic biomarkers.Submitted by Alessandra Estrela-Lima (aestrela@ufba.br) on 2012-02-10T17:46:05Z No. of bitstreams: 1 estrela lima 2011.pdf: 705375 bytes, checksum: f2952082dfbef55fa5c9f46053e963c7 (MD5)Made available in DSpace on 2012-02-10T17:46:05Z (GMT). No. of bitstreams: 1 estrela lima 2011.pdf: 705375 bytes, checksum: f2952082dfbef55fa5c9f46053e963c7 (MD5) Previous issue date: 2011-03Canine mammary carcinomaCD4+/CD8+ ratioMHCI monocytesPrognosisBiomarkersUnderstanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkersBreast Cancer Res Treatinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01engreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5383/4/license.txt1b89a9a0548218172d7c829f87a0eab9MD54ORIGINALestrela lima 2011.pdfestrela lima 2011.pdfapplication/pdf705375https://repositorio.ufba.br/bitstream/ri/5383/3/estrela%20lima%202011.pdff2952082dfbef55fa5c9f46053e963c7MD53TEXTestrela lima 2011.pdf.txtestrela lima 2011.pdf.txtExtracted texttext/plain51033https://repositorio.ufba.br/bitstream/ri/5383/5/estrela%20lima%202011.pdf.txt2139d1d2170c271b35a80f6481980008MD55ri/53832022-10-13 11:27:47.526oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-10-13T14:27:47Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| dc.title.alternative.pt_BR.fl_str_mv |
Breast Cancer Res Treat |
| title |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| spellingShingle |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers Lima, Alessandra Estrela da Silva Canine mammary carcinoma CD4+/CD8+ ratio MHCI monocytes Prognosis Biomarkers |
| title_short |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| title_full |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| title_fullStr |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| title_full_unstemmed |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| title_sort |
Understanding of the immunological heterogeneity of canine mammary carcinomas to provide immunophenotypic features of circulating leukocytes as clinically relevant prognostic biomarkers |
| author |
Lima, Alessandra Estrela da Silva |
| author_facet |
Lima, Alessandra Estrela da Silva Araújo, Márcio Sobreira Silva Costa Neto, João Moreira da Ribeiro, Lorena Damasceno, Karine Araújo D'Assis, Mário Jorge Melhor Heine Martins Filho, Olindo Assis Teixeira-Carvalho, Andréa Serakides, Rogéria Cassali, Geovanni Dantas |
| author_role |
author |
| author2 |
Araújo, Márcio Sobreira Silva Costa Neto, João Moreira da Ribeiro, Lorena Damasceno, Karine Araújo D'Assis, Mário Jorge Melhor Heine Martins Filho, Olindo Assis Teixeira-Carvalho, Andréa Serakides, Rogéria Cassali, Geovanni Dantas |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Lima, Alessandra Estrela da Silva Araújo, Márcio Sobreira Silva Costa Neto, João Moreira da Ribeiro, Lorena Damasceno, Karine Araújo D'Assis, Mário Jorge Melhor Heine Martins Filho, Olindo Assis Teixeira-Carvalho, Andréa Serakides, Rogéria Cassali, Geovanni Dantas Lima, Alessandra Estrela da Silva Araújo, Márcio Sobreira Silva Costa Neto, João Moreira da Ribeiro, Lorena Damasceno, Karine Araújo D'Assis, Mário Jorge Melhor Heine Martins Filho, Olindo Assis Teixeira-Carvalho, Andréa Serakides, Rogéria Cassali, Geovanni Dantas |
| dc.subject.por.fl_str_mv |
Canine mammary carcinoma CD4+/CD8+ ratio MHCI monocytes Prognosis Biomarkers |
| topic |
Canine mammary carcinoma CD4+/CD8+ ratio MHCI monocytes Prognosis Biomarkers |
| description |
Acesso restrito: texto completo. p. 751-763 |
| publishDate |
2012 |
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2012-02-10T17:46:05Z |
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2012 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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1573-7217 |
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v. 131 |
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1573-7217 v. 131 |
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