Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens

Detalhes bibliográficos
Autor(a) principal: Reed, Steven G.
Data de Publicação: 1985
Outros Autores: Roters, Silene B., Inverso, Jill A., Jones, Thomas C., Goidl, Edmond A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/8590
Resumo: Texto completo. Acesso restrito. p. 12–25
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spelling Reed, Steven G.Roters, Silene B.Inverso, Jill A.Jones, Thomas C.Goidl, Edmond A.Reed, Steven G.Roters, Silene B.Inverso, Jill A.Jones, Thomas C.Goidl, Edmond A.2013-02-21T13:02:52Z2013-02-21T13:02:52Z19850008-8749http://www.repositorio.ufba.br/ri/handle/ri/8590v. 96, n. 1Texto completo. Acesso restrito. p. 12–25Antibody responses to T-dependent and T-“independent” antigens were studied in diseasesusceptible (BALB/c and C57BL/lO) and disease-resistant (A/J) mice infected with Leishmania donovani chagasi. Disease-susceptible mice but not disease-resistant mice showed a transient decrease in PFC responses to TNP on a T-dependent carrier (BGG) during the period of 4-8 weeks after infection. Infected disease-susceptible animals also showed increased responses to TNP on a type II T-independent carrier (Ficoll), which persisted until at least 14 weeks after infection. The increased responses were associated with a significant increase in anti-TNP antibody of the lgG2b subclass. When T-enriched spleen cells from infected mice and B-enriched spleen cells from uninfected mice were transferred to irradiated recipients immunized with TNP-Ficoll, increased anti-TNP PFC were observed over numbers seen in irradiated recipients which received both B and T cells from uninfected mice. Increased responses to TNP-Ficoll were also induced by prior administration of soluble leishmania extract in CFA. Infected mice immunized with TNP-LPS, a T-independent type I antigen, also had increased anti-TNP antibody responses, but had normal anti-LPS antibody responses. The elevated antibody production which occurred in response to the T-“independent” antigens could not be attributed to the relatively low polyclonal response which occurred in both disease-resistant and disease-susceptible mice infected with L. donovani chagasi. The observations are consistent with leishmania induced, transient alterations in some T-cell functions including response to haptens on T-dependent carriers, and a lack of down regulation of T-“independent” responses. Subtle lesions in immunoregulation may be important correlates of successful protozoa1 infection and may be responsible for some of the immunologic manifestations of the diseaseSubmitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-02-20T19:16:46Z No. of bitstreams: 1 7777777.pdf: 1873343 bytes, checksum: 86a951a995e33a69147ed8b94c1240c5 (MD5)Approved for entry into archive by Fatima Cleômenis Botelho Maria (botelho@ufba.br) on 2013-02-21T13:02:52Z (GMT) No. of bitstreams: 1 7777777.pdf: 1873343 bytes, checksum: 86a951a995e33a69147ed8b94c1240c5 (MD5)Made available in DSpace on 2013-02-21T13:02:52Z (GMT). No. of bitstreams: 1 7777777.pdf: 1873343 bytes, checksum: 86a951a995e33a69147ed8b94c1240c5 (MD5) Previous issue date: 1985SalvadorCellular Immunologyhttp://dx.doi.org/10.1016/0008-8749(85)90336-3reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAImmune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigensCellular Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL7777777.pdf7777777.pdfapplication/pdf1873343https://repositorio.ufba.br/bitstream/ri/8590/1/7777777.pdf86a951a995e33a69147ed8b94c1240c5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/8590/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT7777777.pdf.txt7777777.pdf.txtExtracted texttext/plain14https://repositorio.ufba.br/bitstream/ri/8590/3/7777777.pdf.txt06b7e51e8fc077b8c75076712e4dd2b3MD53ri/85902022-07-05 14:03:01.434oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
dc.title.alternative.pt_BR.fl_str_mv Cellular Immunology
title Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
spellingShingle Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
Reed, Steven G.
title_short Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
title_full Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
title_fullStr Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
title_full_unstemmed Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
title_sort Immune responses to T-dependent and T-independent antigens during visceral leishmaniasis in mice: Evidence for altered T-cell regulation of immune responses to non-parasite antigens
author Reed, Steven G.
author_facet Reed, Steven G.
Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
author_role author
author2 Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Reed, Steven G.
Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
Reed, Steven G.
Roters, Silene B.
Inverso, Jill A.
Jones, Thomas C.
Goidl, Edmond A.
description Texto completo. Acesso restrito. p. 12–25
publishDate 1985
dc.date.issued.fl_str_mv 1985
dc.date.accessioned.fl_str_mv 2013-02-21T13:02:52Z
dc.date.available.fl_str_mv 2013-02-21T13:02:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/8590
dc.identifier.issn.none.fl_str_mv 0008-8749
dc.identifier.number.pt_BR.fl_str_mv v. 96, n. 1
identifier_str_mv 0008-8749
v. 96, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/8590
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cellular Immunology
publisher.none.fl_str_mv Cellular Immunology
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/0008-8749(85)90336-3
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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