Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16390 |
Resumo: | Texto completo: acesso restrito. p. 58–66 |
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Veras, Robson CavalcanteRodrigues, Karoline GomesFernandes, Maria do Carmo de AlustauGonçalves, Islania Giselia AlbuquerqueBarros, André Luis Branco deAlves, Ricardo JoséNakao, Lia SumieBraga, Valdir de AndradeVasconcelos, Darizy Flavia Silva Amorim deMedeiros, Isac Almeida deVeras, Robson CavalcanteRodrigues, Karoline GomesFernandes, Maria do Carmo de AlustauGonçalves, Islania Giselia AlbuquerqueBarros, André Luis Branco deAlves, Ricardo JoséNakao, Lia SumieBraga, Valdir de AndradeVasconcelos, Darizy Flavia Silva Amorim deMedeiros, Isac Almeida de2014-10-10T15:13:34Z20130160-2446http://repositorio.ufba.br/ri/handle/ri/16390v. 62, n. 1Texto completo: acesso restrito. p. 58–66For many years, nitric oxide (NO) has been studied as an important mediator in the control of vascular tone. Endothelial deficiencies that diminish NO production can result in the development of several future cardiovascular diseases, such as hypertension and arteriosclerosis. In this context, new drugs with potential ability to donate NO have been studied. In this study, 3 aromatic oximes [benzophenone oxime, 4-Cl-benzophenone oxime, and E-cinnamaldehyde oxime (E-CAOx)] induced vasorelaxation in endothelium-denuded and intact superior mesenteric rings precontracted with phenylephrine. E-CAOx demonstrated the most potent effect, and its mechanism of action was evaluated. Vascular reactivity experiments demonstrated that the effect of E-CAOx was reduced by the presence of 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide, 1H[1,2,4,]oxadiazolo[4,3-a]quinoxalin-1-one, and (Rp)-8-(para-chlorophenylthio)guanosine-3',5'-cyclic monophosphorothioate, suggesting the participation of NO/sGC/PKG pathway. NO donation seems to be mediated through nicatinamide adenine dinucleotide phosphate-dependent reductases because 7-ethoxyresorufin decreased the effect of E-CAOx on vascular reactivity and reduced NO formation as detected by flow cytometry using the NO indicator diaminofluorescein 4,5-diacetate. Further downstream of NO donation, K+ subtype channels were also shown to be involved in the E-CAOx vasorelaxant effect. The present study showed that E-CAOx acts like an NO donor, activating NO/sGC/PKG pathway and thus K+ channels.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-29T12:42:22Z No. of bitstreams: 1 00005344-201307000-00008.pdf: 336437 bytes, checksum: 157830b0d31342a7c9eddd5be4db874c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:13:34Z (GMT) No. of bitstreams: 1 00005344-201307000-00008.pdf: 336437 bytes, checksum: 157830b0d31342a7c9eddd5be4db874c (MD5)Made available in DSpace on 2014-10-10T15:13:34Z (GMT). No. of bitstreams: 1 00005344-201307000-00008.pdf: 336437 bytes, checksum: 157830b0d31342a7c9eddd5be4db874c (MD5) Previous issue date: 2013http://dx.doi.org/10.1097/FJC.0b013e31829013ffreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEndotheliumNO donorOximeRatVasorelaxationParticipation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from ratsJournal of Cardiovascular Pharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16390/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINAL00005344-201307000-00008.pdf00005344-201307000-00008.pdfapplication/pdf336437https://repositorio.ufba.br/bitstream/ri/16390/1/00005344-201307000-00008.pdf157830b0d31342a7c9eddd5be4db874cMD51TEXT00005344-201307000-00008.pdf.txt00005344-201307000-00008.pdf.txtExtracted texttext/plain45921https://repositorio.ufba.br/bitstream/ri/16390/3/00005344-201307000-00008.pdf.txt96c34f13cf9244df7861e643a3daf484MD53ri/163902022-07-05 14:03:31.017oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:31Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Cardiovascular Pharmacology |
| title |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| spellingShingle |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats Veras, Robson Cavalcante Endothelium NO donor Oxime Rat Vasorelaxation |
| title_short |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| title_full |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| title_fullStr |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| title_full_unstemmed |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| title_sort |
Participation of nitric oxide pathway in the relaxation response induced by E-cinnamaldehyde oxime in superior mesenteric artery isolated from rats |
| author |
Veras, Robson Cavalcante |
| author_facet |
Veras, Robson Cavalcante Rodrigues, Karoline Gomes Fernandes, Maria do Carmo de Alustau Gonçalves, Islania Giselia Albuquerque Barros, André Luis Branco de Alves, Ricardo José Nakao, Lia Sumie Braga, Valdir de Andrade Vasconcelos, Darizy Flavia Silva Amorim de Medeiros, Isac Almeida de |
| author_role |
author |
| author2 |
Rodrigues, Karoline Gomes Fernandes, Maria do Carmo de Alustau Gonçalves, Islania Giselia Albuquerque Barros, André Luis Branco de Alves, Ricardo José Nakao, Lia Sumie Braga, Valdir de Andrade Vasconcelos, Darizy Flavia Silva Amorim de Medeiros, Isac Almeida de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Veras, Robson Cavalcante Rodrigues, Karoline Gomes Fernandes, Maria do Carmo de Alustau Gonçalves, Islania Giselia Albuquerque Barros, André Luis Branco de Alves, Ricardo José Nakao, Lia Sumie Braga, Valdir de Andrade Vasconcelos, Darizy Flavia Silva Amorim de Medeiros, Isac Almeida de Veras, Robson Cavalcante Rodrigues, Karoline Gomes Fernandes, Maria do Carmo de Alustau Gonçalves, Islania Giselia Albuquerque Barros, André Luis Branco de Alves, Ricardo José Nakao, Lia Sumie Braga, Valdir de Andrade Vasconcelos, Darizy Flavia Silva Amorim de Medeiros, Isac Almeida de |
| dc.subject.por.fl_str_mv |
Endothelium NO donor Oxime Rat Vasorelaxation |
| topic |
Endothelium NO donor Oxime Rat Vasorelaxation |
| description |
Texto completo: acesso restrito. p. 58–66 |
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2013 |
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2013 |
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2014-10-10T15:13:34Z |
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0160-2446 |
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v. 62, n. 1 |
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0160-2446 v. 62, n. 1 |
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