Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/16357 |
Resumo: | Texto completo: acesso restrito. p. 605-611 |
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Sousa, Ana Paula Cavalcanti deValença Neto, Alberto de Aguiar Pires de AguiarMarchionni, Antônio Márcio TeixeiraRamos, Marília de AraújoReis Júnior, João Alves dosPereira, Manoela Carrera Martinez CavalcanteCangussu, Maria Cristina TeixeiraReis, Silvia Regina de AlmeidaPinheiro, Antonio Luiz BarbosaSousa, Ana Paula Cavalcanti deValença Neto, Alberto de Aguiar Pires de AguiarMarchionni, Antônio Márcio TeixeiraRamos, Marília de AraújoReis Júnior, João Alves dosPereira, Manoela Carrera Martinez CavalcanteCangussu, Maria Cristina TeixeiraReis, Silvia Regina de AlmeidaPinheiro, Antonio Luiz Barbosa2014-10-07T15:21:11Z20111549-5418http://repositorio.ufba.br/ri/handle/ri/16357v. 29, n. 9Texto completo: acesso restrito. p. 605-611The aim of the present investigation was to evaluate transforming growth factor β (TGF-β) expression on cutaneous wounds in rodents treated or not treated with LED light. Background: TGF-β is a multifunctional cytokine that presents a central action during tissue repair. Although several studies both in vitro and in vivo have shown that LED phototherapy influences tissue repair, a full understanding of the mechanisms involved in its usage, such as in the modulation of some growth factors, remains unclear. Materials and Methods: Under general anesthesia, 24 young adult male Wistar rats weighing 200–250 g had one excisional wound created on the dorsum of each, and were randomly distributed into two groups: G0 (Control) and G1 (LED, λ700 ± 20 nm, 16 mW, SAEF = 5 J/cm2, Illuminated Area = 2 cm2, 8 mWcm2, 626 s) Each group was subdivided into three subgroups according to the animal death timing (2, 4, and 6 days). LED phototherapy started immediately after surgery and was repeated every other day during the experimental time. Following animal death, specimens were removed, routinely processed to wax, cut and immunomarked with polyclonal anti-TGF-β, and underwent histological analysis by light microscopy. The mean area of expression of each group was calculated. The data were statistically analyzed using ANOVA and Tukey's test. Results: The area of the expression of TGF-β on LED-irradiated animals was significantly smaller than on controls at day 2 (p = 0.013). No significant difference was found at later times. It is concluded that the use of LED light, at these specific parameters, caused an inhibition of the expression of TGF-β at an early stage of the healing process.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-04-15T13:32:45Z No. of bitstreams: 1 Ana Paula Cavalcanti de Sousa.pdf: 843823 bytes, checksum: eb378a1db4647dd1369b54c1993850f4 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-07T15:21:11Z (GMT) No. of bitstreams: 1 Ana Paula Cavalcanti de Sousa.pdf: 843823 bytes, checksum: eb378a1db4647dd1369b54c1993850f4 (MD5)Made available in DSpace on 2014-10-07T15:21:11Z (GMT). No. of bitstreams: 1 Ana Paula Cavalcanti de Sousa.pdf: 843823 bytes, checksum: eb378a1db4647dd1369b54c1993850f4 (MD5) Previous issue date: 2011http://dx.doi.org/ 10.1089/pho.2010.2833reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAPhototherapyTransforming Growth Factor betaEffect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent ModelPhotomedicine and Laser Surgeryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALAna Paula Cavalcanti de Sousa.pdfAna Paula Cavalcanti de Sousa.pdfapplication/pdf843823https://repositorio.ufba.br/bitstream/ri/16357/1/Ana%20Paula%20Cavalcanti%20de%20Sousa.pdfeb378a1db4647dd1369b54c1993850f4MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/16357/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXTAna Paula Cavalcanti de Sousa.pdf.txtAna Paula Cavalcanti de Sousa.pdf.txtExtracted texttext/plain22957https://repositorio.ufba.br/bitstream/ri/16357/3/Ana%20Paula%20Cavalcanti%20de%20Sousa.pdf.txt4727ae88bc5ca5d5770f7dc358f041ccMD53ri/163572022-07-05 14:03:42.31oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:42Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| dc.title.alternative.pt_BR.fl_str_mv |
Photomedicine and Laser Surgery |
| title |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| spellingShingle |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model Sousa, Ana Paula Cavalcanti de Phototherapy Transforming Growth Factor beta |
| title_short |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| title_full |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| title_fullStr |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| title_full_unstemmed |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| title_sort |
Effect of LED Phototherapy (λ700 ± 20 nm) on TGF-β Expression During Wound Healing: An Immunohistochemical Study in a Rodent Model |
| author |
Sousa, Ana Paula Cavalcanti de |
| author_facet |
Sousa, Ana Paula Cavalcanti de Valença Neto, Alberto de Aguiar Pires de Aguiar Marchionni, Antônio Márcio Teixeira Ramos, Marília de Araújo Reis Júnior, João Alves dos Pereira, Manoela Carrera Martinez Cavalcante Cangussu, Maria Cristina Teixeira Reis, Silvia Regina de Almeida Pinheiro, Antonio Luiz Barbosa |
| author_role |
author |
| author2 |
Valença Neto, Alberto de Aguiar Pires de Aguiar Marchionni, Antônio Márcio Teixeira Ramos, Marília de Araújo Reis Júnior, João Alves dos Pereira, Manoela Carrera Martinez Cavalcante Cangussu, Maria Cristina Teixeira Reis, Silvia Regina de Almeida Pinheiro, Antonio Luiz Barbosa |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sousa, Ana Paula Cavalcanti de Valença Neto, Alberto de Aguiar Pires de Aguiar Marchionni, Antônio Márcio Teixeira Ramos, Marília de Araújo Reis Júnior, João Alves dos Pereira, Manoela Carrera Martinez Cavalcante Cangussu, Maria Cristina Teixeira Reis, Silvia Regina de Almeida Pinheiro, Antonio Luiz Barbosa Sousa, Ana Paula Cavalcanti de Valença Neto, Alberto de Aguiar Pires de Aguiar Marchionni, Antônio Márcio Teixeira Ramos, Marília de Araújo Reis Júnior, João Alves dos Pereira, Manoela Carrera Martinez Cavalcante Cangussu, Maria Cristina Teixeira Reis, Silvia Regina de Almeida Pinheiro, Antonio Luiz Barbosa |
| dc.subject.por.fl_str_mv |
Phototherapy Transforming Growth Factor beta |
| topic |
Phototherapy Transforming Growth Factor beta |
| description |
Texto completo: acesso restrito. p. 605-611 |
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2011 |
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2011 |
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2014-10-07T15:21:11Z |
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1549-5418 |
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v. 29, n. 9 |
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1549-5418 v. 29, n. 9 |
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http://repositorio.ufba.br/ri/handle/ri/16357 |
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