Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://www.repositorio.ufba.br/ri/handle/ri/3747 |
Resumo: | Acesso ao texto completo: http://www.sciencedirect.com/science/article/pii/S0264410X1100733X |
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Barreto, Mauricio LimaPereira, Susan M.Pilger, DanielCruz Filho, Álvaro Augusto Souza daCunha, Sergio S.Sant'Anna, Clemax CoutoIchihara, Maria Y.Genser, BerndRodrigues, Laura C.Barreto, Mauricio LimaPereira, Susan M.Pilger, DanielCruz Filho, Álvaro Augusto Souza daCunha, Sergio S.Sant'Anna, Clemax CoutoIchihara, Maria Y.Genser, BerndRodrigues, Laura C.2011-11-16T11:50:46Z2011-11-16T11:50:46Z2011-070264-410Xhttp://www.repositorio.ufba.br/ri/handle/ri/3747v.29, n.31, p.4875-4877, 2011Acesso ao texto completo: http://www.sciencedirect.com/science/article/pii/S0264410X1100733XBCG revaccination is still used in some tuberculosis endemic countries. Until now, the little evidence available suggested that BCG revaccination confers very limited additional protection, although there was no information on whether protection depends on the setting and age of revaccination, or if protection increases with time since vaccination. Here we report on an extended follow up of the BCG-REVAC trial, a cluster randomised trial conducted in the Brazilian cities Salvador and Manaus including over 200,000 children aged 7–14 years aimed to evaluate the efficacy of BCG revaccination in children who had received neonatal BCG vaccination. With the extended follow-up (9 years) and the additional cases accrued we now have enough power to report vaccine efficacy separately for the two cities (with different distances from Equator and presumably different prevalence of non-tuberculosis mycobacteria), and by age at vaccination and clinical form. The overall vaccine efficacy was 12% (−2 to 24%) as compared to 9% (−16 to 29%) for the 5-year follow up. Vaccine efficacy was higher in Salvador (19%, 3 to 33%) than in Manaus (1%, −27 to 27%) with the highest vaccine efficacy in children from Salvador aged <11 years at revaccination (33%, 3 to 54%). The findings are in line with the hypothesis that BCG vaccination offers higher efficacy in low NTMb prevalence, and show that revaccination with BCG can offer weak protection in selected subgroups.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2011-11-16T11:50:46Z No. of bitstreams: 1 Evidence of an effect of BCG revaccination on incidence of tuberculosis in school.doc: 26624 bytes, checksum: c950da7c0c8d8da908f16a0ede3e091d (MD5)Made available in DSpace on 2011-11-16T11:50:46Z (GMT). No. of bitstreams: 1 Evidence of an effect of BCG revaccination on incidence of tuberculosis in school.doc: 26624 bytes, checksum: c950da7c0c8d8da908f16a0ede3e091d (MD5) Previous issue date: 2011-07KidlingtonBCGVaccine EfficacyTuberculosisRevaccinationSchool AgeEvidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trialVaccineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALEvidence of an effect of BCG revaccination on incidence of tuberculosis in school.docEvidence of an effect of BCG revaccination on incidence of tuberculosis in school.docapplication/msword26624https://repositorio.ufba.br/bitstream/ri/3747/1/Evidence%20of%20an%20effect%20of%20BCG%20revaccination%20on%20incidence%20of%20tuberculosis%20in%20school.docc950da7c0c8d8da908f16a0ede3e091dMD51LICENSElicense.txtlicense.txttext/plain1907https://repositorio.ufba.br/bitstream/ri/3747/2/license.txt5a243c40ea908a5ef658f64a2e4c85aaMD52ri/37472022-07-05 14:03:51.798oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| dc.title.alternative.pt_BR.fl_str_mv |
Vaccine |
| title |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| spellingShingle |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial Barreto, Mauricio Lima BCG Vaccine Efficacy Tuberculosis Revaccination School Age |
| title_short |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| title_full |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| title_fullStr |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| title_full_unstemmed |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| title_sort |
Evidence of an effect of BCG revaccination on incidence of tuberculosis in school-aged children in Brazil: second report of the BCG-REVAC cluster-randomised trial |
| author |
Barreto, Mauricio Lima |
| author_facet |
Barreto, Mauricio Lima Pereira, Susan M. Pilger, Daniel Cruz Filho, Álvaro Augusto Souza da Cunha, Sergio S. Sant'Anna, Clemax Couto Ichihara, Maria Y. Genser, Bernd Rodrigues, Laura C. |
| author_role |
author |
| author2 |
Pereira, Susan M. Pilger, Daniel Cruz Filho, Álvaro Augusto Souza da Cunha, Sergio S. Sant'Anna, Clemax Couto Ichihara, Maria Y. Genser, Bernd Rodrigues, Laura C. |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barreto, Mauricio Lima Pereira, Susan M. Pilger, Daniel Cruz Filho, Álvaro Augusto Souza da Cunha, Sergio S. Sant'Anna, Clemax Couto Ichihara, Maria Y. Genser, Bernd Rodrigues, Laura C. Barreto, Mauricio Lima Pereira, Susan M. Pilger, Daniel Cruz Filho, Álvaro Augusto Souza da Cunha, Sergio S. Sant'Anna, Clemax Couto Ichihara, Maria Y. Genser, Bernd Rodrigues, Laura C. |
| dc.subject.por.fl_str_mv |
BCG Vaccine Efficacy Tuberculosis Revaccination School Age |
| topic |
BCG Vaccine Efficacy Tuberculosis Revaccination School Age |
| description |
Acesso ao texto completo: http://www.sciencedirect.com/science/article/pii/S0264410X1100733X |
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2011 |
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2011-11-16T11:50:46Z |
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2011-11-16T11:50:46Z |
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2011-07 |
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0264-410X |
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v.29, n.31, p.4875-4877, 2011 |
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