Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle

Detalhes bibliográficos
Autor(a) principal: Maia Junior, Hugo
Data de Publicação: 2004
Outros Autores: Maltez, Amélia, Studart, Eduardo, Athayde, Célia Maria Soares, Coutinho, Elsimar Metzker
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6740
Resumo: Trabalho completo: acesso restrito, p. 1242–1247
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spelling Maia Junior, HugoMaltez, AméliaStudart, EduardoAthayde, Célia Maria SoaresCoutinho, Elsimar MetzkerMaia Junior, HugoMaltez, AméliaStudart, EduardoAthayde, Célia Maria SoaresCoutinho, Elsimar Metzker2012-09-17T17:13:16Z2004-111470-0328http://www.repositorio.ufba.br/ri/handle/ri/6740v. 111, n. 11Trabalho completo: acesso restrito, p. 1242–1247Objective To determine the presence of proteins related to proliferation (Ki-67) and apoptosis (Bcl-2, p53) in endometrial polyps and normal endometrium during the menstrual cycle. Design Retrospective study using paraffin embedded tissue. Setting Hospital affiliated to the university. Population Premenopausal patients with endometrial polyps. Methods Seventy-eight premenopausal patients in different phases of the menstrual cycle were submitted to polypectomy using the Bettocchi hysteroscope. Immunohistochemistry was used to detect the expression of these proteins in endometrial polyps. One hundred and eighteen normal endometrial biopsies were used as controls. Main outcome measures Detection of Bcl-2 and Ki-67 expression by immunohistochemistry. Results In endometrial polyps, Ki-67, p53 and Bcl-2 expression was detected with more frequency during the proliferative than during the luteal phase of the cycle. Similar findings were observed in the normal endometrium. Conclusion Endometrial polyps undergo cyclic changes in the expression of their proteins related to proliferation and apoptosis during the menstrual cycle, similar to those of the cycling endometrium.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-09-17T17:13:15Z No. of bitstreams: 1 (208).pdf: 455218 bytes, checksum: da1b4a9efabdacda4f6f5a43ec01dd1c (MD5)Made available in DSpace on 2012-09-17T17:13:16Z (GMT). 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dc.title.pt_BR.fl_str_mv Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
dc.title.alternative.pt_BR.fl_str_mv BJOG: An International Journal of Obstetrics & Gynaecology
title Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
spellingShingle Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
Maia Junior, Hugo
title_short Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
title_full Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
title_fullStr Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
title_full_unstemmed Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
title_sort Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle
author Maia Junior, Hugo
author_facet Maia Junior, Hugo
Maltez, Amélia
Studart, Eduardo
Athayde, Célia Maria Soares
Coutinho, Elsimar Metzker
author_role author
author2 Maltez, Amélia
Studart, Eduardo
Athayde, Célia Maria Soares
Coutinho, Elsimar Metzker
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Maia Junior, Hugo
Maltez, Amélia
Studart, Eduardo
Athayde, Célia Maria Soares
Coutinho, Elsimar Metzker
Maia Junior, Hugo
Maltez, Amélia
Studart, Eduardo
Athayde, Célia Maria Soares
Coutinho, Elsimar Metzker
description Trabalho completo: acesso restrito, p. 1242–1247
publishDate 2004
dc.date.issued.fl_str_mv 2004-11
dc.date.accessioned.fl_str_mv 2012-09-17T17:13:16Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6740
dc.identifier.issn.none.fl_str_mv 1470-0328
dc.identifier.number.pt_BR.fl_str_mv v. 111, n. 11
identifier_str_mv 1470-0328
v. 111, n. 11
url http://www.repositorio.ufba.br/ri/handle/ri/6740
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1111/j.1471-0528.2004.00406.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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