Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents

Detalhes bibliográficos
Autor(a) principal: Leitão, Fernanda
Data de Publicação: 2013
Outros Autores: Leitão, Suzana G., Almeida, Mara Zélia de, Cantos, Jéssica, Coelho, Tatiane, Silva, Pedro Eduardo A. da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/15875
Resumo: Texto completo: acesso restrito. p. 513–521
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spelling Leitão, FernandaLeitão, Suzana G.Almeida, Mara Zélia deCantos, JéssicaCoelho, TatianeSilva, Pedro Eduardo A. daLeitão, FernandaLeitão, Suzana G.Almeida, Mara Zélia deCantos, JéssicaCoelho, TatianeSilva, Pedro Eduardo A. da2014-09-09T14:37:34Z20130378-8741http://repositorio.ufba.br/ri/handle/ri/15875v. 149, n. 2Texto completo: acesso restrito. p. 513–521Ethnopharmacological relevance: Several medicinal plants are traditionally traded in open-air markets in Rio de Janeiro State (Brazil) to treat tuberculosis (TB) and related symptoms. Aims of the study: Conduct a survey in the open-air markets of 20 cities of Rio de Janeiro State to find medicinal plants that are popularly used to treat tuberculosis and other related diseases and assess their in vitro antimycobacterial activity. Materials and methods: We used direct observation and semi-structured interviews and asked herbalists to list species (free listing) in order to gather data about the plant species most commonly used for lung problems. We calculated a Salience Index and acquired two species of “erva-de-passarinho” (mistletoe), Struthanthus marginatus and Struthanthus concinnus (Loranthaceae), commonly used to treat tuberculosis for a bioassay-guided isolation of the antimycobacterial active principles. Extracts, fractions and isolated compounds of both species were assayed in vitro against susceptible (H37Rv) and rifampicin-resistant (ATCC 35338) Mycobacterium tuberculosis strains. Results: From the interviews, we generated a list of 36 plant species belonging to 12 families. The mistletoes Struthanthus marginatus and Struthanthus concinnus showed high Salience Index values among plants used to treat tuberculosis. Bioassay-guided fractionation of hexane extracts from both species led to the isolation and/or identification of steroids and terpenoids. The Minimum Inhibitory Concentration (MIC) of the extracts and isolated compounds ranged from 25 to 200 μg/mL. Some of the isolated compounds have been previously assayed against Mycobacterium tuberculosis, others are reported here for the first time (obtusifoliol: MIC H37Rv 50 μg/mL, MIC ATCC 35338 12.5 μg/mL; 3-O-n-acil-lup-20(29)-en-3β,7β,15α-triol: MIC H37Rv 200 μg/mL, MIC ATCC 35338 100 μg/mL). Conclusions: This study demonstrated the importance of ethnobotanical surveys in markets as a source for new drugs and also for scientific validation of folk medicine.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-05T12:41:49Z No. of bitstreams: 1 1-s2.0-S0378874113004984-main.pdf: 1099119 bytes, checksum: c712e6b772c9f6a5b4dc54ed8df193c2 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-09-09T14:37:34Z (GMT) No. of bitstreams: 1 1-s2.0-S0378874113004984-main.pdf: 1099119 bytes, checksum: c712e6b772c9f6a5b4dc54ed8df193c2 (MD5)Made available in DSpace on 2014-09-09T14:37:34Z (GMT). No. of bitstreams: 1 1-s2.0-S0378874113004984-main.pdf: 1099119 bytes, checksum: c712e6b772c9f6a5b4dc54ed8df193c2 (MD5) Previous issue date: 2013http://dx.doi.org/10.1016/j.jep.2013.07.009reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBATuberculosisEthnobotanyOpen-air marketsMedicinal plantsStruthanthusMedicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agentsJournal of Ethnopharmacologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0378874113004984-main.pdf1-s2.0-S0378874113004984-main.pdfapplication/pdf1099119https://repositorio.ufba.br/bitstream/ri/15875/1/1-s2.0-S0378874113004984-main.pdfc712e6b772c9f6a5b4dc54ed8df193c2MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15875/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52TEXT1-s2.0-S0378874113004984-main.pdf.txt1-s2.0-S0378874113004984-main.pdf.txtExtracted texttext/plain51630https://repositorio.ufba.br/bitstream/ri/15875/3/1-s2.0-S0378874113004984-main.pdf.txtf865e1a43b56e5cf07ecbfdfaa700a96MD53ri/158752022-07-05 14:03:32.679oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:32Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
dc.title.alternative.pt_BR.fl_str_mv Journal of Ethnopharmacology
title Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
spellingShingle Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
Leitão, Fernanda
Tuberculosis
Ethnobotany
Open-air markets
Medicinal plants
Struthanthus
title_short Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
title_full Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
title_fullStr Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
title_full_unstemmed Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
title_sort Medicinal plants from open-air markets in the State of Rio de Janeiro, Brazil as a potential source of new antimycobacterial agents
author Leitão, Fernanda
author_facet Leitão, Fernanda
Leitão, Suzana G.
Almeida, Mara Zélia de
Cantos, Jéssica
Coelho, Tatiane
Silva, Pedro Eduardo A. da
author_role author
author2 Leitão, Suzana G.
Almeida, Mara Zélia de
Cantos, Jéssica
Coelho, Tatiane
Silva, Pedro Eduardo A. da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Leitão, Fernanda
Leitão, Suzana G.
Almeida, Mara Zélia de
Cantos, Jéssica
Coelho, Tatiane
Silva, Pedro Eduardo A. da
Leitão, Fernanda
Leitão, Suzana G.
Almeida, Mara Zélia de
Cantos, Jéssica
Coelho, Tatiane
Silva, Pedro Eduardo A. da
dc.subject.por.fl_str_mv Tuberculosis
Ethnobotany
Open-air markets
Medicinal plants
Struthanthus
topic Tuberculosis
Ethnobotany
Open-air markets
Medicinal plants
Struthanthus
description Texto completo: acesso restrito. p. 513–521
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-09-09T14:37:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/15875
dc.identifier.issn.none.fl_str_mv 0378-8741
dc.identifier.number.pt_BR.fl_str_mv v. 149, n. 2
identifier_str_mv 0378-8741
v. 149, n. 2
url http://repositorio.ufba.br/ri/handle/ri/15875
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.jep.2013.07.009
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