Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study.
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFBA |
Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/19049 |
Resumo: | During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease. |
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Cardoso, Cristiane WanderleyRibeiro, Guilherme SousaReis, Mitermayer GalvãoFlannery, BrendanReis, Joice Neves2016-05-03T17:30:47Z2016-05-03T17:30:47Z2015-041932-6203http://repositorio.ufba.br/ri/handle/ri/19049v.10, n.4, p.1-12During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease.Submitted by Maria Creuza Silva (mariakreuza@yahoo.com.br) on 2016-05-03T17:30:47Z No. of bitstreams: 1 Art Per Estrang Guilherme Ribeiro3. 2015.pdf: 192847 bytes, checksum: 3923e714bd34177a85d9eee7b9e02bb0 (MD5)Made available in DSpace on 2016-05-03T17:30:47Z (GMT). No. of bitstreams: 1 Art Per Estrang Guilherme Ribeiro3. 2015.pdf: 192847 bytes, checksum: 3923e714bd34177a85d9eee7b9e02bb0 (MD5) Previous issue date: 2015-04San FranciscoPublic Library of ScienceBrasilhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395143/pdf/pone.0123734.pdfreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMeningococcal DiseaseMeningococcal VaccineEpidemicEffectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study.PLoS Oneinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessengORIGINALArt Per Estrang Guilherme Ribeiro3. 2015.pdfArt Per Estrang Guilherme Ribeiro3. 2015.pdfapplication/pdf192847https://repositorio.ufba.br/bitstream/ri/19049/1/Art%20Per%20Estrang%20Guilherme%20Ribeiro3.%202015.pdf3923e714bd34177a85d9eee7b9e02bb0MD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/19049/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTArt Per Estrang Guilherme Ribeiro3. 2015.pdf.txtArt Per Estrang Guilherme Ribeiro3. 2015.pdf.txtExtracted texttext/plain38971https://repositorio.ufba.br/bitstream/ri/19049/3/Art%20Per%20Estrang%20Guilherme%20Ribeiro3.%202015.pdf.txte4edaa38c385444798bd66f15722722dMD53ri/190492022-03-10 14:48:14.835oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-03-10T17:48:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
dc.title.pt_BR.fl_str_mv |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
dc.title.alternative.pt_BR.fl_str_mv |
PLoS One |
title |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
spellingShingle |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. Cardoso, Cristiane Wanderley Meningococcal Disease Meningococcal Vaccine Epidemic |
title_short |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
title_full |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
title_fullStr |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
title_full_unstemmed |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
title_sort |
Effectiveness of Meningococcal C conjugate vaccine in Salvador, Brazil: a case-control study. |
author |
Cardoso, Cristiane Wanderley |
author_facet |
Cardoso, Cristiane Wanderley Ribeiro, Guilherme Sousa Reis, Mitermayer Galvão Flannery, Brendan Reis, Joice Neves |
author_role |
author |
author2 |
Ribeiro, Guilherme Sousa Reis, Mitermayer Galvão Flannery, Brendan Reis, Joice Neves |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Cardoso, Cristiane Wanderley Ribeiro, Guilherme Sousa Reis, Mitermayer Galvão Flannery, Brendan Reis, Joice Neves |
dc.subject.por.fl_str_mv |
Meningococcal Disease Meningococcal Vaccine Epidemic |
topic |
Meningococcal Disease Meningococcal Vaccine Epidemic |
description |
During a citywide epidemic of serogroup C meningococcal disease in Salvador in 2010, Brazil, the state government initiated mass vaccination targeting two age groups with high attack rates: individuals aged <5 years and 10–24 years. More than 600,000 doses of meningococcal serogroup C conjugate vaccines were administered. We performed a casecontrol study to evaluate vaccine uptake, document vaccine effectiveness and identify reasons for non-vaccination. Methods and Findings Population-based surveillance identified patients with laboratory-confirmed invasive meningococcal C (MenC) disease during 2010. Information on MenC vaccination was obtained from case patients and age-matched individuals from the same neighborhoods. MenC vaccine effectiveness was estimated based on the exact odds ratios obtained by conditional logistic regression analysis. Of 51 laboratory-confirmed cases of serogroup C meningococcal disease among patients <5 and 10–24 years of age 50 were included in the study and matched with 240 controls. Overall case-fatality was 25%.MenC vaccine coverage among controls increased from 7.1%to 70.2% after initiation of the vaccination campaign. None of the 50 case patients but 70 (29.2%) of the 240 control individuals, including 59 (70.2%) of 84 matched with cases from the period afterMenC vaccination, had received at least one MenC vaccine dose. Overall effectiveness of MenC was 98%with a lower 95%exact confidence limit of 89%. Conclusions MenC vaccines administered during the meningococcal epidemic were highly effective, suggesting that rapid vaccine uptake through campaigns contributed to control of meningococcal disease. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-04 |
dc.date.accessioned.fl_str_mv |
2016-05-03T17:30:47Z |
dc.date.available.fl_str_mv |
2016-05-03T17:30:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.ufba.br/ri/handle/ri/19049 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
dc.identifier.number.pt_BR.fl_str_mv |
v.10, n.4, p.1-12 |
identifier_str_mv |
1932-6203 v.10, n.4, p.1-12 |
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http://repositorio.ufba.br/ri/handle/ri/19049 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Brasil |
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Public Library of Science |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395143/pdf/pone.0123734.pdf |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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