Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics

Detalhes bibliográficos
Autor(a) principal: Oliveira, Irismar Reis de
Data de Publicação: 2009
Outros Autores: Nunes, Paulo Menezes, Coutinho, Domingos Macedo, Sena, Eduardo Pondé de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/3287
Resumo: P. 52-56.
id UFBA-2_7e9bf7561040e22d0cd8ce606755ca9d
oai_identifier_str oai:repositorio.ufba.br:ri/3287
network_acronym_str UFBA-2
network_name_str Repositório Institucional da UFBA
repository_id_str 1932
spelling Oliveira, Irismar Reis deNunes, Paulo MenezesCoutinho, Domingos MacedoSena, Eduardo Pondé deOliveira, Irismar Reis deNunes, Paulo MenezesCoutinho, Domingos MacedoSena, Eduardo Pondé de2011-10-13T11:43:18Z2011-10-13T11:43:18Z2009-031516-4446http://www.repositorio.ufba.br/ri/handle/ri/3287v. 31, n. 1.P. 52-56.OBJETIVO: Revisar a eficácia do placebo em comparação com a dos antipsicóticos atípicos e típicos no tratamento da esquizofrenia e do transtorno esquizoafetivo, bem como avaliar a pertinência do uso do placebo nos ensaios clínicos com antipsicóticos. MÉTODO: Foram incluídos estudos nos quais os antipsicóticos atípicos foram comparados com antipsicóticos típicos e placebo simultaneamente. A pesquisa bibliográfica incluiu os termos "amisulprida", "aripiprazol", "clozapina", "olanzapina", "quetiapina", "risperidona", "sertindol", "ziprasidona" e "zotepina". Os principais parâmetros de eficácia foram a proporção de "eventos" (definidos como deterioração ou falta de melhora de pelo menos 20% na Positive and Negative Syndrome Scale ou Brief Psychiatric Rating Scale) e os riscos relativos combinados (efeitos randômicos), com seus respectivos intervalos de confiança de 95%. Foram também estimados os tamanhos de amostras nos estudos em que a droga pesquisada fosse comparada com um antipsicótico típico ou com placebo. RESULTADOS: As taxas de eficácia combinada foram de 40,8%, 34,9% e 21,3%, respectivamente, para os antipsicóticos atípicos, antipsicóticos típicos e placebo. Cento e sessenta e seis pacientes teriam de ser incluídos quando a nova droga fosse comparada com placebo se os cálculos fossem baseados na diferença de 20% encontrada entre o antipsicótico atípico e placebo, ao passo que 2.054 teriam de ser incluídos se a diferença procurada fosse aquela encontrada entre o antipsicótico atípico e o antipsicótico típico, isto é, 6%. Os insucessos terapêuticos estimados seriam de 115 entre os 166 pacientes quando a droga em estudo fosse comparada com placebo, e de 1.274 entre os 2.054 pacientes quando fosse comparada com um antipsicótico típico. CONCLUSÕES: Os estudos controlados por placebo podem reduzir o número de indivíduos expostos aos efeitos prejudiciais de drogas ineficazes.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2011-10-13T11:43:18Z No. of bitstreams: 1 a13v31n1.pdf: 517964 bytes, checksum: cea73048e3925b48ffed9174bb88d7e2 (MD5)Made available in DSpace on 2011-10-13T11:43:18Z (GMT). No. of bitstreams: 1 a13v31n1.pdf: 517964 bytes, checksum: cea73048e3925b48ffed9174bb88d7e2 (MD5) Previous issue date: 2009-03São PauloAgentes antipsicóticosMetanáliseEfeito placeboTranstorno esquizoafetivoEsquizofreniaAntipsychotic agentsMeta-analysisPlacebo effectSchizoaffective disorderSchizophreniaReview of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychoticsRevista Brasileira de Psiquiatriainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAinfo:eu-repo/semantics/openAccessORIGINALa13v31n1.pdfa13v31n1.pdfapplication/pdf517964https://repositorio.ufba.br/bitstream/ri/3287/1/a13v31n1.pdfcea73048e3925b48ffed9174bb88d7e2MD51LICENSElicense.txtlicense.txttext/plain1906https://repositorio.ufba.br/bitstream/ri/3287/2/license.txt4ee7aa44169069467953cafbec6d2791MD52TEXTa13v31n1.pdf.txta13v31n1.pdf.txtExtracted texttext/plain27318https://repositorio.ufba.br/bitstream/ri/3287/3/a13v31n1.pdf.txtc6fefdc9476545fb593971b8a49fdf0cMD53ri/32872022-07-05 14:04:01.478oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:01Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
dc.title.alternative.pt_BR.fl_str_mv Revista Brasileira de Psiquiatria
title Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
spellingShingle Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
Oliveira, Irismar Reis de
Agentes antipsicóticos
Metanálise
Efeito placebo
Transtorno esquizoafetivo
Esquizofrenia
Antipsychotic agents
Meta-analysis
Placebo effect
Schizoaffective disorder
Schizophrenia
title_short Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
title_full Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
title_fullStr Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
title_full_unstemmed Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
title_sort Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics
author Oliveira, Irismar Reis de
author_facet Oliveira, Irismar Reis de
Nunes, Paulo Menezes
Coutinho, Domingos Macedo
Sena, Eduardo Pondé de
author_role author
author2 Nunes, Paulo Menezes
Coutinho, Domingos Macedo
Sena, Eduardo Pondé de
author2_role author
author
author
dc.contributor.author.fl_str_mv Oliveira, Irismar Reis de
Nunes, Paulo Menezes
Coutinho, Domingos Macedo
Sena, Eduardo Pondé de
Oliveira, Irismar Reis de
Nunes, Paulo Menezes
Coutinho, Domingos Macedo
Sena, Eduardo Pondé de
dc.subject.por.fl_str_mv Agentes antipsicóticos
Metanálise
Efeito placebo
Transtorno esquizoafetivo
Esquizofrenia
Antipsychotic agents
Meta-analysis
Placebo effect
Schizoaffective disorder
Schizophrenia
topic Agentes antipsicóticos
Metanálise
Efeito placebo
Transtorno esquizoafetivo
Esquizofrenia
Antipsychotic agents
Meta-analysis
Placebo effect
Schizoaffective disorder
Schizophrenia
description P. 52-56.
publishDate 2009
dc.date.issued.fl_str_mv 2009-03
dc.date.accessioned.fl_str_mv 2011-10-13T11:43:18Z
dc.date.available.fl_str_mv 2011-10-13T11:43:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/3287
dc.identifier.issn.none.fl_str_mv 1516-4446
dc.identifier.number.pt_BR.fl_str_mv v. 31, n. 1.
identifier_str_mv 1516-4446
v. 31, n. 1.
url http://www.repositorio.ufba.br/ri/handle/ri/3287
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
bitstream.url.fl_str_mv https://repositorio.ufba.br/bitstream/ri/3287/1/a13v31n1.pdf
https://repositorio.ufba.br/bitstream/ri/3287/2/license.txt
https://repositorio.ufba.br/bitstream/ri/3287/3/a13v31n1.pdf.txt
bitstream.checksum.fl_str_mv cea73048e3925b48ffed9174bb88d7e2
4ee7aa44169069467953cafbec6d2791
c6fefdc9476545fb593971b8a49fdf0c
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)
repository.mail.fl_str_mv
_version_ 1798057560091131904

Registros relacionados