Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study

Detalhes bibliográficos
Autor(a) principal: Gamba, C. O.
Data de Publicação: 2013
Outros Autores: Dias, E. J., Ribeiro, L. G. R., Campos, Leila Carvalho, Lima, Alessandra Estrela da Silva, Ferreira, E., Cassali, Geovanni Dantas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13740
Resumo: p. 241–246
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spelling Gamba, C. O.Dias, E. J.Ribeiro, L. G. R.Campos, Leila CarvalhoLima, Alessandra Estrela da SilvaFerreira, E.Cassali, Geovanni DantasGamba, C. O.Dias, E. J.Ribeiro, L. G. R.Campos, Leila CarvalhoLima, Alessandra Estrela da SilvaFerreira, E.Cassali, Geovanni Dantas2013-11-19T19:48:29Z20131090-0233http://repositorio.ufba.br/ri/handle/ri/13740v. 196, n. 2p. 241–246Invasive micropapillary carcinoma (IMPC) of the mammary gland, despite its rare occurrence in humans and dogs, is an important neoplasm due to its aggressive behaviour. The aim of this study was to evaluate the clinicopathological and immunophenotypical characteristics of IMPC and to determine the overall survival of dogs with this tumour. Of the selected cases, the majority had >3 cm neoplasms (15/19, 78.95%) and lymph node metastases (16/16, 100%), but only two cases (2/9, 22.2%) had distant metastases. The IMPCs were classified as either pure (15/22, 68.18%) or mixed (7/22, 31.82%) types. There was a predominance of moderate histological grade tumours (16 grade II) and the average overall survival was 120 days. Positive immunohistochemical staining for epithelial membrane antigen and negative staining for CD-31, p63 and cytokeratin (CK) AE1AE3 in cystic formations confirmed the micropapillary nature of these neoplasms. A proportion of cases exhibited positive epithelial staining for p63 (4/20, 20%) and CK34βE12 (20/22, 90.9%). Most cases were positive for oestrogen (19/20, 95%) and progesterone (19/20, 95%) receptors, but lacked HER-2 (16/22, 72.72%) and epidermal growth factor receptor (15/22, 68.18%) over-expression. The mean proliferation index was 14.8%. The findings demonstrate that, similar to humans, canine IMPCs behave aggressively with high rates of metastasis to regional lymph nodes and short overall survival timesSubmitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-11-18T18:26:27Z No. of bitstreams: 1 4444444.pdf: 2653063 bytes, checksum: 5d9789c561b8fecb741a89625170054c (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-19T19:48:29Z (GMT) No. of bitstreams: 1 4444444.pdf: 2653063 bytes, checksum: 5d9789c561b8fecb741a89625170054c (MD5)Made available in DSpace on 2013-11-19T19:48:29Z (GMT). No. of bitstreams: 1 4444444.pdf: 2653063 bytes, checksum: 5d9789c561b8fecb741a89625170054c (MD5) Previous issue date: 2013SalvadorVeterinary Journalhttp://www.sciencedirect.com/science/article/pii/S1090023312003796reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInvasive micropapillary carcinomaMammary glandDogImmunohistochemistryHistopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective studyVeterinary Journalinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL4444444.pdf4444444.pdfapplication/pdf2653063https://repositorio.ufba.br/bitstream/ri/13740/1/4444444.pdf5d9789c561b8fecb741a89625170054cMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/13740/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT4444444.pdf.txt4444444.pdf.txtExtracted texttext/plain34032https://repositorio.ufba.br/bitstream/ri/13740/3/4444444.pdf.txt70b75a70b95eb8ad32b017b708cd74c0MD53ri/137402022-07-05 14:04:03.05oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:04:03Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
dc.title.alternative.pt_BR.fl_str_mv Veterinary Journal
title Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
spellingShingle Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
Gamba, C. O.
Invasive micropapillary carcinoma
Mammary gland
Dog
Immunohistochemistry
title_short Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
title_full Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
title_fullStr Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
title_full_unstemmed Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
title_sort Histopathological and immunohistochemical assessment of invasive micropapillary mammary carcinoma in dogs: A retrospective study
author Gamba, C. O.
author_facet Gamba, C. O.
Dias, E. J.
Ribeiro, L. G. R.
Campos, Leila Carvalho
Lima, Alessandra Estrela da Silva
Ferreira, E.
Cassali, Geovanni Dantas
author_role author
author2 Dias, E. J.
Ribeiro, L. G. R.
Campos, Leila Carvalho
Lima, Alessandra Estrela da Silva
Ferreira, E.
Cassali, Geovanni Dantas
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gamba, C. O.
Dias, E. J.
Ribeiro, L. G. R.
Campos, Leila Carvalho
Lima, Alessandra Estrela da Silva
Ferreira, E.
Cassali, Geovanni Dantas
Gamba, C. O.
Dias, E. J.
Ribeiro, L. G. R.
Campos, Leila Carvalho
Lima, Alessandra Estrela da Silva
Ferreira, E.
Cassali, Geovanni Dantas
dc.subject.por.fl_str_mv Invasive micropapillary carcinoma
Mammary gland
Dog
Immunohistochemistry
topic Invasive micropapillary carcinoma
Mammary gland
Dog
Immunohistochemistry
description p. 241–246
publishDate 2013
dc.date.accessioned.fl_str_mv 2013-11-19T19:48:29Z
dc.date.issued.fl_str_mv 2013
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13740
dc.identifier.issn.none.fl_str_mv 1090-0233
dc.identifier.number.pt_BR.fl_str_mv v. 196, n. 2
identifier_str_mv 1090-0233
v. 196, n. 2
url http://repositorio.ufba.br/ri/handle/ri/13740
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Veterinary Journal
publisher.none.fl_str_mv Veterinary Journal
dc.source.pt_BR.fl_str_mv http://www.sciencedirect.com/science/article/pii/S1090023312003796
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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