Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14282 |
Resumo: | Texto completo: acesso restrito. p. 612-618. |
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Santos, Silvane Maria BragaRodrigues Junior, WaldyrMuniz, André Luís NunesBasílio, VanessaNeva, Franklin A.Dutra, Walderez OrnelasGollob, Kenneth JohnJacobson, StevenCarvalho Filho, Edgar Marcelino deSantos, Silvane Maria BragaRodrigues Junior, WaldyrMuniz, André Luís NunesBasílio, VanessaNeva, Franklin A.Dutra, Walderez OrnelasGollob, Kenneth JohnJacobson, StevenCarvalho Filho, Edgar Marcelino de2014-01-07T13:33:33Z20050022-1899,http://repositorio.ufba.br/ri/handle/ri/14282v.191, n. 4Texto completo: acesso restrito. p. 612-618.Human T cell lymphotropic virus type 1 (HTLV-1) infection is associated with an exacerbated type 1 immune response and secretion of high levels of proinflammatory cytokines. In contrast, helminthic infection induces a type 2 immune response. In the present study, the cytokine profile in HTLV-1 carriers coinfected with helminths (Strongyloides stercoralis and/or Schistosoma mansoni) was compared with that in HTLV-1 carriers not coinfected with helminths. Levels of interferon (IFN)-γ were higher in HTLV-1 carriers not coinfected with helminths than in HTLV-1 carriers coinfected with helminths (P < .05). The overall frequency of IFN-γ-expressing CD8+ and CD4+ cells was decreased in HTLV-1 carriers coinfected with helminths (P > .05). The percentage of interleukin (IL)-5- and IL-10-expressing T cells in HTLV-1 carriers coinfected with helminths was higher than that in HTLV-1 carriers not coinfected with helminths (P < .05). Moreover, we found that the prevalence of helminthic infection was 7-fold higher in HTLV-1 carriers than in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (P < .05). These data show that helminthic infection decreases activation of type 1 cells, which may influence the clinical outcome of HTLV-1 infection.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2013-11-29T11:17:26Z No. of bitstreams: 1 Silvane B. Santos.pdf: 435684 bytes, checksum: 61d491af11b14d5ca3b7008acbc433af (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-07T13:33:33Z (GMT) No. of bitstreams: 1 Silvane B. Santos.pdf: 435684 bytes, checksum: 61d491af11b14d5ca3b7008acbc433af (MD5)Made available in DSpace on 2014-01-07T13:33:33Z (GMT). No. of bitstreams: 1 Silvane B. Santos.pdf: 435684 bytes, checksum: 61d491af11b14d5ca3b7008acbc433af (MD5) Previous issue date: 2005http://dx.doi.org/ 10.1086/427560reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHuman T-lymphotropic virus 1CD4-Positive T-LymphocytesMyelitisParaparesis Tropical SpasticHelminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALSilvane B. Santos.pdfSilvane B. Santos.pdfapplication/pdf435684https://repositorio.ufba.br/bitstream/ri/14282/1/Silvane%20B.%20Santos.pdf61d491af11b14d5ca3b7008acbc433afMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14282/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXTSilvane B. Santos.pdf.txtSilvane B. 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| dc.title.pt_BR.fl_str_mv |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Infectious Diseases |
| title |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| spellingShingle |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Santos, Silvane Maria Braga Human T-lymphotropic virus 1 CD4-Positive T-Lymphocytes Myelitis Paraparesis Tropical Spastic |
| title_short |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_full |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_fullStr |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_full_unstemmed |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_sort |
Helminthic Infection Down-Regulates Type 1 Immune Responses in Human T Cell Lymphotropic Virus Type 1 (HTLV-1) Carriers and Is More Prevalent in HTLV-1 Carriers than in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| author |
Santos, Silvane Maria Braga |
| author_facet |
Santos, Silvane Maria Braga Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Silvane Maria Braga Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de Santos, Silvane Maria Braga Rodrigues Junior, Waldyr Muniz, André Luís Nunes Basílio, Vanessa Neva, Franklin A. Dutra, Walderez Ornelas Gollob, Kenneth John Jacobson, Steven Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
Human T-lymphotropic virus 1 CD4-Positive T-Lymphocytes Myelitis Paraparesis Tropical Spastic |
| topic |
Human T-lymphotropic virus 1 CD4-Positive T-Lymphocytes Myelitis Paraparesis Tropical Spastic |
| description |
Texto completo: acesso restrito. p. 612-618. |
| publishDate |
2005 |
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2005 |
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2014-01-07T13:33:33Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://repositorio.ufba.br/ri/handle/ri/14282 |
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0022-1899, |
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v.191, n. 4 |
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0022-1899, v.191, n. 4 |
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http://repositorio.ufba.br/ri/handle/ri/14282 |
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