Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells

Detalhes bibliográficos
Autor(a) principal: Costa, Dirceu Joaquim
Data de Publicação: 2004
Outros Autores: Favali, Cecilia Beatriz Fiuza, Andrade, Jorge Clarencio Souza, Macêdo, Lilian Maria Afonso de, Conceição, Viviane Nascimento da, Miranda, José Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/7749
Resumo: Texto completo: acesso restrito. p. 1298-1305
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spelling Costa, Dirceu JoaquimFavali, Cecilia Beatriz FiuzaAndrade, Jorge Clarencio SouzaMacêdo, Lilian Maria Afonso deConceição, Viviane Nascimento daMiranda, José CarlosCosta, Dirceu JoaquimFavali, Cecilia Beatriz FiuzaAndrade, Jorge Clarencio SouzaMacêdo, Lilian Maria Afonso deConceição, Viviane Nascimento daMiranda, José Carlos2013-01-04T13:28:06Z20040019-9567http://www.repositorio.ufba.br/ri/handle/ri/7749v. 72, n. 3Texto completo: acesso restrito. p. 1298-1305In this report, we describe an investigation of the effects of Lutzomyia longipalpis sand fly salivary gland homogenates (SGH) on cytokine production and expression of costimulatory molecules on human monocytes, macrophages (Mφs), and dendritic cells (DCs). SGH of L. longipalpis induced an increase in interleukin-6 (IL-6), IL-8 and IL-12p40 production but a decrease in tumor necrosis factor alpha and IL-10 production by lipopolysaccharida (LPS)-stimulated monocytes. We also examined the expression of costimulatory molecules on the surface of monocytes, Mφs, and DCs. Whereas SGH affected the expression of these molecules on monocytes and Mφs, it had little effect on these molecules on DCs. However, when DCs were generated from human monocytes in the presence of SGH, SGH inhibited the expression of costimulatory molecules. In addition, a decrease in the maturation of DCs induced by CD40L was observed in the presence of SGH. Finally, preincubating SGH with human sera containing anti-SGH-specific antibodies abolished the effects of SGH on cytokine production by LPS-stimulated monocytes.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2013-01-04T13:28:06Z No. of bitstreams: 1 1298.full.pdf: 334154 bytes, checksum: d91f4da097072ac0ee187e2666bd16dd (MD5)Made available in DSpace on 2013-01-04T13:28:06Z (GMT). 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dc.title.pt_BR.fl_str_mv Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
dc.title.alternative.pt_BR.fl_str_mv Infection and Immunity
title Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
spellingShingle Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
Costa, Dirceu Joaquim
title_short Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
title_full Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
title_fullStr Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
title_full_unstemmed Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
title_sort Lutzomyia longipalpis Salivary Gland Homogenate Impairs Cytokine Production and Costimulatory Molecule Expression on Human Monocytes and Dendritic Cells
author Costa, Dirceu Joaquim
author_facet Costa, Dirceu Joaquim
Favali, Cecilia Beatriz Fiuza
Andrade, Jorge Clarencio Souza
Macêdo, Lilian Maria Afonso de
Conceição, Viviane Nascimento da
Miranda, José Carlos
author_role author
author2 Favali, Cecilia Beatriz Fiuza
Andrade, Jorge Clarencio Souza
Macêdo, Lilian Maria Afonso de
Conceição, Viviane Nascimento da
Miranda, José Carlos
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Costa, Dirceu Joaquim
Favali, Cecilia Beatriz Fiuza
Andrade, Jorge Clarencio Souza
Macêdo, Lilian Maria Afonso de
Conceição, Viviane Nascimento da
Miranda, José Carlos
Costa, Dirceu Joaquim
Favali, Cecilia Beatriz Fiuza
Andrade, Jorge Clarencio Souza
Macêdo, Lilian Maria Afonso de
Conceição, Viviane Nascimento da
Miranda, José Carlos
description Texto completo: acesso restrito. p. 1298-1305
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2013-01-04T13:28:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/7749
dc.identifier.issn.none.fl_str_mv 0019-9567
dc.identifier.number.pt_BR.fl_str_mv v. 72, n. 3
identifier_str_mv 0019-9567
v. 72, n. 3
url http://www.repositorio.ufba.br/ri/handle/ri/7749
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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