Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats

Detalhes bibliográficos
Autor(a) principal: Ferreira, Hilda Silva
Data de Publicação: 2004
Outros Autores: Silva, Emilio de Castro e, Cointeiro, Carla, Oliveira, Elenilda, Faustino, Thiallan Nery, Fregoneze, Josmara Bartolomei
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6728
Resumo: Trabalho completo: acesso restrito, p.48–58
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spelling Ferreira, Hilda SilvaSilva, Emilio de Castro eCointeiro, CarlaOliveira, ElenildaFaustino, Thiallan NeryFregoneze, Josmara BartolomeiFerreira, Hilda SilvaSilva, Emilio de Castro eCointeiro, CarlaOliveira, ElenildaFaustino, Thiallan NeryFregoneze, Josmara Bartolomei2012-09-17T14:31:25Z2004-11-260006-8993http://www.repositorio.ufba.br/ri/handle/ri/6728v. 1028, n. 1Trabalho completo: acesso restrito, p.48–58The aim of the present study was to investigate the participation of central 5-HT3 receptors in the control of blood pressure and heart rate (HR) of non-stressed and stressed rats. The pharmacological stimulation of brain 5-HT3 receptors by third ventricle injections of the selective 5-HT3 receptor agonist m-CPBG induced a significant decrease in blood pressure in non-stressed rats and impaired the hypertensive response induced by restraint stress. The blockade of brain 5-HT3 receptors by the central administration of the selective 5-HT3 antagonist ondansetron elicited a significant increase in blood pressure in non-stressed rats. Conversely, the hypertensive response induced by restraint stress was not affected by central administration of ondansetron. Additionally, baroreflex-mediated bradycardia during phenylephrine-induced hypertensive response was preserved in non-stressed animals receiving third ventricle injections of m-CPBG, while the baroreflex-mediated tachycardia that occurs during the hypotensive response induced by the administration of sodium nitroprusside was impaired. It is concluded that the serotoninergic component represented by the brain 5-HT3 receptors exerts a tonic inhibitory influence on the central control of blood pressure in non-stressed rats, probably by a sympathoinhibitory-related mechanism. On the other hand, during stress, this central 5-HT3-dependent inhibitory drive is overwhelmed by the different neurochemical systems that harmonically trigger and sustain the hypertensive response.Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-09-17T14:31:25Z No. of bitstreams: 1 (203).pdf: 413063 bytes, checksum: 3dbe0006fea529382522cc5e33399841 (MD5)Made available in DSpace on 2012-09-17T14:31:25Z (GMT). No. of bitstreams: 1 (203).pdf: 413063 bytes, checksum: 3dbe0006fea529382522cc5e33399841 (MD5) Previous issue date: 2004-11-26Elsevierhttp://dx.doi.org/10.1016/j.brainres.2004.08.063reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAEndocrine and autonomic regulationCardiovascular regulationRole of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed ratsBrain Researchinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL(203).pdf(203).pdfapplication/pdf413063https://repositorio.ufba.br/bitstream/ri/6728/1/%28203%29.pdf3dbe0006fea529382522cc5e33399841MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/6728/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT(203).pdf.txt(203).pdf.txtExtracted texttext/plain46145https://repositorio.ufba.br/bitstream/ri/6728/3/%28203%29.pdf.txt76959317dd08b4dab9fcdec1d9665d7aMD53ri/67282022-07-05 14:03:08.698oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:08Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
dc.title.alternative.pt_BR.fl_str_mv Brain Research
title Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
spellingShingle Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
Ferreira, Hilda Silva
Endocrine and autonomic regulation
Cardiovascular regulation
title_short Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
title_full Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
title_fullStr Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
title_full_unstemmed Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
title_sort Role of central 5-HT3 receptors in the control of blood pressure in stressed and non-stressed rats
author Ferreira, Hilda Silva
author_facet Ferreira, Hilda Silva
Silva, Emilio de Castro e
Cointeiro, Carla
Oliveira, Elenilda
Faustino, Thiallan Nery
Fregoneze, Josmara Bartolomei
author_role author
author2 Silva, Emilio de Castro e
Cointeiro, Carla
Oliveira, Elenilda
Faustino, Thiallan Nery
Fregoneze, Josmara Bartolomei
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Hilda Silva
Silva, Emilio de Castro e
Cointeiro, Carla
Oliveira, Elenilda
Faustino, Thiallan Nery
Fregoneze, Josmara Bartolomei
Ferreira, Hilda Silva
Silva, Emilio de Castro e
Cointeiro, Carla
Oliveira, Elenilda
Faustino, Thiallan Nery
Fregoneze, Josmara Bartolomei
dc.subject.por.fl_str_mv Endocrine and autonomic regulation
Cardiovascular regulation
topic Endocrine and autonomic regulation
Cardiovascular regulation
description Trabalho completo: acesso restrito, p.48–58
publishDate 2004
dc.date.issued.fl_str_mv 2004-11-26
dc.date.accessioned.fl_str_mv 2012-09-17T14:31:25Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6728
dc.identifier.issn.none.fl_str_mv 0006-8993
dc.identifier.number.pt_BR.fl_str_mv v. 1028, n. 1
identifier_str_mv 0006-8993
v. 1028, n. 1
url http://www.repositorio.ufba.br/ri/handle/ri/6728
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.brainres.2004.08.063
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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instname_str Universidade Federal da Bahia (UFBA)
instacron_str UFBA
institution UFBA
reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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