Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs

Detalhes bibliográficos
Autor(a) principal: Goto, Yasuyuki
Data de Publicação: 2009
Outros Autores: Howard, Randall F., Bhatia, Ajay, Trigo, Joelma, Nakatani, Maria, Martins Netto, Eduardo, Reed, Steven G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/13258
Resumo: Texto completo: acesso restrito. p. 215-220
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spelling Goto, YasuyukiHoward, Randall F.Bhatia, AjayTrigo, JoelmaNakatani, MariaMartins Netto, EduardoReed, Steven G.Goto, YasuyukiHoward, Randall F.Bhatia, AjayTrigo, JoelmaNakatani, MariaMartins Netto, EduardoReed, Steven G.2013-10-15T16:52:14Z20090304-4017http://www.repositorio.ufba.br/ri/handle/ri/13258v. 160, n. 3-4Texto completo: acesso restrito. p. 215-220Leishmania infantum is a causative agent of endemic zoonotic visceral leishmaniasis (VL) in regions of South America and the Mediterranean. Dogs are the major reservoirs for L. infantum in these regions, and control of disease in dogs could have a significant impact on human disease. Although dogs share many symptoms of VL with humans as a result of L. infantum infection, they also show some unique clinical manifestations, which are often a combination of visceral and cutaneous leishmaniasis, suggesting different mechanisms of disease development in dogs and humans. Here, we compare antibody responses of dogs and humans with VL to various defined leishmanial antigens. Parasite lysate and K39, the two most commonly used antigens for serodiagnosis of VL, detected the highest levels of antibodies in both humans and dogs with VL, whereas the recognition patterns of these antigens were distinct between the hosts. Among other defined antigens tested, LmSTI1 and CPB detected higher levels of antibodies in dogs and humans, respectively. These results indicate there is a difference between humans and dogs in antigen recognition patterns during VL. We infer that different strategies may need to be used in development of vaccines and diagnostics for humans and for dogs. In addition, we show a correlation between antibody titers to several antigens and severity of clinical symptoms during canine VL.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-15T16:52:13Z No. of bitstreams: 1 1-s2.0-S0304401708006328-main.pdf: 293929 bytes, checksum: 2ec1c790101791af6875363d6a756ed4 (MD5)Made available in DSpace on 2013-10-15T16:52:14Z (GMT). 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dc.title.pt_BR.fl_str_mv Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
dc.title.alternative.pt_BR.fl_str_mv Veterinary Parasitology
title Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
spellingShingle Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
Goto, Yasuyuki
Zoonosis
Leishmania infantum
Antigen
Dog
title_short Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
title_full Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
title_fullStr Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
title_full_unstemmed Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
title_sort Distinct antigen recognition pattern during zoonotic visceral leishmaniasis in humans and dogs
author Goto, Yasuyuki
author_facet Goto, Yasuyuki
Howard, Randall F.
Bhatia, Ajay
Trigo, Joelma
Nakatani, Maria
Martins Netto, Eduardo
Reed, Steven G.
author_role author
author2 Howard, Randall F.
Bhatia, Ajay
Trigo, Joelma
Nakatani, Maria
Martins Netto, Eduardo
Reed, Steven G.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Goto, Yasuyuki
Howard, Randall F.
Bhatia, Ajay
Trigo, Joelma
Nakatani, Maria
Martins Netto, Eduardo
Reed, Steven G.
Goto, Yasuyuki
Howard, Randall F.
Bhatia, Ajay
Trigo, Joelma
Nakatani, Maria
Martins Netto, Eduardo
Reed, Steven G.
dc.subject.por.fl_str_mv Zoonosis
Leishmania infantum
Antigen
Dog
topic Zoonosis
Leishmania infantum
Antigen
Dog
description Texto completo: acesso restrito. p. 215-220
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2013-10-15T16:52:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/13258
dc.identifier.issn.none.fl_str_mv 0304-4017
dc.identifier.number.pt_BR.fl_str_mv v. 160, n. 3-4
identifier_str_mv 0304-4017
v. 160, n. 3-4
url http://www.repositorio.ufba.br/ri/handle/ri/13258
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.vetpar.2008.10.097
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
instacron:UFBA
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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