IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection

Detalhes bibliográficos
Autor(a) principal: Novoa, R.
Data de Publicação: 2011
Outros Autores: Bacellar, Maria Olívia Amado Ramos, Nascimento, M., Cardoso, T. M., Ramasawmy, Rajendranath, Oliveira, W. N., Schriefer, Nicolaus Albert Borges, Carvalho Filho, Edgar Marcelino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5548
Resumo: Acesso restrito: Texto completo. p. 132-136.
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spelling Novoa, R.Bacellar, Maria Olívia Amado RamosNascimento, M.Cardoso, T. M.Ramasawmy, RajendranathOliveira, W. N.Schriefer, Nicolaus Albert BorgesCarvalho Filho, Edgar Marcelino deNovoa, R.Bacellar, Maria Olívia Amado RamosNascimento, M.Cardoso, T. M.Ramasawmy, RajendranathOliveira, W. N.Schriefer, Nicolaus Albert BorgesCarvalho Filho, Edgar Marcelino de2012-03-21T18:44:28Z20110141-9838http://www.repositorio.ufba.br/ri/handle/ri/5548v. 33, n. 2Acesso restrito: Texto completo. p. 132-136.Cutaneous leishmaniasis (CL) is characterized by high production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were detected by ELISA and real-time PCR. IFN-c and TNF-a levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL. mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infectionSubmitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-03-21T18:44:28Z No. of bitstreams: 1 __ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf: 274617 bytes, checksum: 8ae7e8c59e8bd7ef37cfa311f61ad07b (MD5)Made available in DSpace on 2012-03-21T18:44:28Z (GMT). No. of bitstreams: 1 __ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf: 274617 bytes, checksum: 8ae7e8c59e8bd7ef37cfa311f61ad07b (MD5) Previous issue date: 2011DOI: 10.1111/j.1365-3024.2010.01256.xreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAcutaneous leishmaniasisIL-17Leishmania braziliensisregulatory cytokinessubclinical infectionIL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis InfectionParasite Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01enginfo:eu-repo/semantics/openAccessORIGINAL__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdfapplication/pdf274617https://repositorio.ufba.br/bitstream/ri/5548/1/__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf8ae7e8c59e8bd7ef37cfa311f61ad07bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/5548/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf.txt__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf.txtExtracted texttext/plain21226https://repositorio.ufba.br/bitstream/ri/5548/3/__ac.els-cdn.com_S026441...f5b4f5fe3819c7cce114160d874ad.pdf.txt9344a8fecb4617babfd9b8da7afd1ad5MD53ri/55482022-07-05 14:03:20.652oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:20Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
dc.title.alternative.pt_BR.fl_str_mv Parasite Immunology
title IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
spellingShingle IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
Novoa, R.
cutaneous leishmaniasis
IL-17
Leishmania braziliensis
regulatory cytokines
subclinical infection
title_short IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
title_full IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
title_fullStr IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
title_full_unstemmed IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
title_sort IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
author Novoa, R.
author_facet Novoa, R.
Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
author_role author
author2 Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Novoa, R.
Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
Novoa, R.
Bacellar, Maria Olívia Amado Ramos
Nascimento, M.
Cardoso, T. M.
Ramasawmy, Rajendranath
Oliveira, W. N.
Schriefer, Nicolaus Albert Borges
Carvalho Filho, Edgar Marcelino de
dc.subject.por.fl_str_mv cutaneous leishmaniasis
IL-17
Leishmania braziliensis
regulatory cytokines
subclinical infection
topic cutaneous leishmaniasis
IL-17
Leishmania braziliensis
regulatory cytokines
subclinical infection
description Acesso restrito: Texto completo. p. 132-136.
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2012-03-21T18:44:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5548
dc.identifier.issn.none.fl_str_mv 0141-9838
dc.identifier.number.pt_BR.fl_str_mv v. 33, n. 2
identifier_str_mv 0141-9838
v. 33, n. 2
url http://www.repositorio.ufba.br/ri/handle/ri/5548
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.pt_BR.fl_str_mv DOI: 10.1111/j.1365-3024.2010.01256.x
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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