Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study

Detalhes bibliográficos
Autor(a) principal: Dourado, Maria Inês Costa
Data de Publicação: 1997
Outros Autores: Martínez-Maza, Otoniel, Kishimoto, Tadamitsu, Suzuki, Hiromasa, Detels, Roger
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/12730
Resumo: p. 781-788
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spelling Dourado, Maria Inês CostaMartínez-Maza, OtonielKishimoto, TadamitsuSuzuki, HiromasaDetels, RogerDourado, Maria Inês CostaMartínez-Maza, OtonielKishimoto, TadamitsuSuzuki, HiromasaDetels, Roger2013-08-26T13:28:14Z2013-08-26T13:28:14Z19970889-2229http://www.repositorio.ufba.br/ri/handle/ri/12730v. 13, n. 9p. 781-788Since the beginning of the AIDS epidemic, there has been considerable research on the etiology of Kaposi's sarcoma (KS) among HlV-infected individuals. A number of studies have confirmed that HIV or HIV-encoded products can interact with human cells to induce the production of cytokines, including interleukin 6 (IL-6). In vitro observations have indicated that AIDS-KS cells can produce significant levels of IL-6 and also respond to this cytokine. Preliminary data suggested that IL-6 may be elevated among HlV-infected individuals that subsequently develop AIDS-KS. The objective of this study was to determine if elevated levels of IL- 6 are associated with an increased incidence of AIDS-KS compared to other AIDS-defining illnesses such as opportunistic infections (OIs). Serum IL-6 levels were determined by ELISA in frozen sera collected from participants in the Multicenter AIDS Cohort Study (MACS) at 6 months prior to AIDS diagnosis, in 73 cases (AIDS-KS), and 152 controls (OI). Elevated IL-6 levels were more prevalent among men with AIDS-OI than those with AIDS-KS: crude odds ratio (OR), 0.4 (95% CI, 0.2-0.9). Models of multivaríate logistic regression were used to study potential confounders. Sexual behavior variables did not seem to confound the association between IL-6 and AIDS-KS. The higher prevalence of IL-6 among controls could be explained by the association of higher levels of IL-6 with lower levels of CD4 T cell number. IL-6 may be a marker of severe immune dysfunction among HIV-infected individuals.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-08-26T13:28:14Z No. of bitstreams: 1 2222222222222.pdf: 1288636 bytes, checksum: 19d87f8cd2e12b4f562d7aa604838ae5 (MD5)Made available in DSpace on 2013-08-26T13:28:14Z (GMT). No. of bitstreams: 1 2222222222222.pdf: 1288636 bytes, checksum: 19d87f8cd2e12b4f562d7aa604838ae5 (MD5) Previous issue date: 1997SalvadorAIDS Research and Human Retroviruseshttp://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/pdf/10.1089/aid.1997.13.781reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAInterleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort StudyAIDS Research and Human Retrovirusesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleenginfo:eu-repo/semantics/openAccessORIGINAL2222222222222.pdf2222222222222.pdfapplication/pdf1288636https://repositorio.ufba.br/bitstream/ri/12730/1/2222222222222.pdf19d87f8cd2e12b4f562d7aa604838ae5MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/12730/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT2222222222222.pdf.txt2222222222222.pdf.txtExtracted texttext/plain39826https://repositorio.ufba.br/bitstream/ri/12730/3/2222222222222.pdf.txtfe6d7ab7364c494fac650eefca1808c9MD53ri/127302022-08-26 11:02:51.088oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-26T14:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
dc.title.alternative.pt_BR.fl_str_mv AIDS Research and Human Retroviruses
title Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
spellingShingle Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
Dourado, Maria Inês Costa
title_short Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
title_full Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
title_fullStr Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
title_full_unstemmed Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
title_sort Interleukin 6 and AIDS-Associated Kaposi's Sarcoma: A Nested Case Control Study within the Multicenter AIDS Cohort Study
author Dourado, Maria Inês Costa
author_facet Dourado, Maria Inês Costa
Martínez-Maza, Otoniel
Kishimoto, Tadamitsu
Suzuki, Hiromasa
Detels, Roger
author_role author
author2 Martínez-Maza, Otoniel
Kishimoto, Tadamitsu
Suzuki, Hiromasa
Detels, Roger
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Dourado, Maria Inês Costa
Martínez-Maza, Otoniel
Kishimoto, Tadamitsu
Suzuki, Hiromasa
Detels, Roger
Dourado, Maria Inês Costa
Martínez-Maza, Otoniel
Kishimoto, Tadamitsu
Suzuki, Hiromasa
Detels, Roger
description p. 781-788
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2013-08-26T13:28:14Z
dc.date.available.fl_str_mv 2013-08-26T13:28:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/12730
dc.identifier.issn.none.fl_str_mv 0889-2229
dc.identifier.number.pt_BR.fl_str_mv v. 13, n. 9
identifier_str_mv 0889-2229
v. 13, n. 9
url http://www.repositorio.ufba.br/ri/handle/ri/12730
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv AIDS Research and Human Retroviruses
publisher.none.fl_str_mv AIDS Research and Human Retroviruses
dc.source.pt_BR.fl_str_mv http://online.liebertpub.com.ez10.periodicos.capes.gov.br/doi/pdf/10.1089/aid.1997.13.781
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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