rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Badaró, Roberto José da Silva
Data de Publicação: 1996
Outros Autores: Benson, Darin R., EuhiIio, M. C., Freire, M., Cunha, S., M. Netto, E., Sampaio, D. Pedral, Madureira, C., Burns, J. M., Houghton, R. L., David, John R., Reed, Steven G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/13659
Resumo: Texto completo. Acesso restrito. p. 758-761
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spelling Badaró, Roberto José da SilvaBenson, Darin R.EuhiIio, M. C.Freire, M.Cunha, S.M. Netto, E.Sampaio, D. PedralMadureira, C.Burns, J. M.Houghton, R. L.David, John R.Reed, Steven G.Badaró, Roberto José da SilvaBenson, Darin R.EuhiIio, M. C.Freire, M.Cunha, S.M. Netto, E.Sampaio, D. PedralMadureira, C.Burns, J. M.Houghton, R. L.David, John R.Reed, Steven G.2013-11-16T12:33:54Z19960022-1899http://repositorio.ufba.br/ri/handle/ri/13659Texto completo. Acesso restrito. p. 758-761The diagnosis of visceralleishmaniasis (VL), a serious and often fatal parasitic disease caused by members of the Leishmania donovani complex, remains problematic. Current methods rely on clinical criteria, parasite identification in aspirate material, and serology. The latter methods use crude antigen preparations lacking in specificity. A previously described cloned antigen, rK39, of Leishmania specific for all membersofthe L. donovani complex(L. chagasi,L. donovani, L. infantum) was very useful in the serodiagnosis by ELISA of both human and canine VL. The present study demonstrated that rK39 seroreactivity correlated with active disease. The sera from early or selfhealing infected subjects reacted with leishmaniallysate and were generallynonreactive with rK39. These data demonstrate the utility of rK39 in the serodiagnosis of VLand as an indicator of active disease.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-09-09T19:28:22Z No. of bitstreams: 1 4444444444asa.pdf: 975943 bytes, checksum: 7a84425efb490f5e22056a061acd6b4b (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-16T12:33:54Z (GMT) No. of bitstreams: 1 4444444444asa.pdf: 975943 bytes, checksum: 7a84425efb490f5e22056a061acd6b4b (MD5)Made available in DSpace on 2013-11-16T12:33:54Z (GMT). No. of bitstreams: 1 4444444444asa.pdf: 975943 bytes, checksum: 7a84425efb490f5e22056a061acd6b4b (MD5) Previous issue date: 1996SalvadorJournal of Infectious Diseaseshttp://jid.oxfordjournals.org.ez10.periodicos.capes.gov.br/content/173/3/758.full.pdf+htmlreponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBArK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral LeishmaniasisJournal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL4444444444asa.pdf4444444444asa.pdfapplication/pdf975943https://repositorio.ufba.br/bitstream/ri/13659/1/4444444444asa.pdf7a84425efb490f5e22056a061acd6b4bMD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13659/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT4444444444asa.pdf.txt4444444444asa.pdf.txtExtracted texttext/plain644https://repositorio.ufba.br/bitstream/ri/13659/3/4444444444asa.pdf.txtc251cf7d36829039528935165f71e14fMD53ri/136592022-09-22 11:47:47.152oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-09-22T14:47:47Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false
dc.title.pt_BR.fl_str_mv rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
dc.title.alternative.pt_BR.fl_str_mv Journal of Infectious Diseases
title rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
spellingShingle rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
Badaró, Roberto José da Silva
title_short rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
title_full rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
title_fullStr rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
title_full_unstemmed rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
title_sort rK39: A Cloned Antigen of Leishmania chagasi that Predicts Active Visceral Leishmaniasis
author Badaró, Roberto José da Silva
author_facet Badaró, Roberto José da Silva
Benson, Darin R.
EuhiIio, M. C.
Freire, M.
Cunha, S.
M. Netto, E.
Sampaio, D. Pedral
Madureira, C.
Burns, J. M.
Houghton, R. L.
David, John R.
Reed, Steven G.
author_role author
author2 Benson, Darin R.
EuhiIio, M. C.
Freire, M.
Cunha, S.
M. Netto, E.
Sampaio, D. Pedral
Madureira, C.
Burns, J. M.
Houghton, R. L.
David, John R.
Reed, Steven G.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Badaró, Roberto José da Silva
Benson, Darin R.
EuhiIio, M. C.
Freire, M.
Cunha, S.
M. Netto, E.
Sampaio, D. Pedral
Madureira, C.
Burns, J. M.
Houghton, R. L.
David, John R.
Reed, Steven G.
Badaró, Roberto José da Silva
Benson, Darin R.
EuhiIio, M. C.
Freire, M.
Cunha, S.
M. Netto, E.
Sampaio, D. Pedral
Madureira, C.
Burns, J. M.
Houghton, R. L.
David, John R.
Reed, Steven G.
description Texto completo. Acesso restrito. p. 758-761
publishDate 1996
dc.date.issued.fl_str_mv 1996
dc.date.accessioned.fl_str_mv 2013-11-16T12:33:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/13659
dc.identifier.issn.none.fl_str_mv 0022-1899
identifier_str_mv 0022-1899
url http://repositorio.ufba.br/ri/handle/ri/13659
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Journal of Infectious Diseases
publisher.none.fl_str_mv Journal of Infectious Diseases
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