Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis

Detalhes bibliográficos
Autor(a) principal: Barbosa, Valter Lucas Chaves
Data de Publicação: 2010
Outros Autores: Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/5642
Resumo: p. 504-507
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spelling Barbosa, Valter Lucas ChavesAndrade, Zilton de AraújoBarbosa, Valter Lucas ChavesAndrade, Zilton de Araújo2012-04-19T11:23:52Z2012-04-19T11:23:52Z20100037-8682http://www.repositorio.ufba.br/ri/handle/ri/5642v. 43, n. 5.p. 504-507Introduction: Septal fibrosis of the liver regularly develops in rats infected with the nematode Capillaria hepatica. Curative treatment of the infection prevents the development of septal fibrosis when intervention occurs up to postinfection day (PID) 15, but not later. The present investigation aimed to demonstrate which parasitic factors are present when the process of septal fibrosis can no longer be prevented by curative treatment. Methods: Wistar rats were infected with 600 embryonated eggs of C. hepatica administered by gavage and treated with ivermectin and mebendazole in separate groups at PIDs 10, 12, 15, 17 or 20. Rats from each group and their nontreated controls, were killed and examined 40 days after the end of treatment. Results: Findings by PID 15 were compatible with the stage of complete maturation of infection, when worms and eggs were fully developed and a complex host-parasite multifocal necroinflammatory reaction showed greater intensity, but with no signs of septal fibrosis, which appeared from PID 17 onward. Conclusions: Since the worms spontaneously died by PID 15, not only septal fibrosis production, but also its maintenance and further development appeared dependent on the presence of eggs, which were the only parasitic factor remaining thereafter.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-04-19T11:23:52Z No. of bitstreams: 1 __www.scielo.br_pdf_rsbmt_v43n5_v43n5a06.pdf: 961970 bytes, checksum: efa5174c17f131e3d0e06ba85f022a9a (MD5)Made available in DSpace on 2012-04-19T11:23:52Z (GMT). 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dc.title.pt_BR.fl_str_mv Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
dc.title.alternative.pt_BR.fl_str_mv REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL
title Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
spellingShingle Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
Barbosa, Valter Lucas Chaves
Hepatic fibrosis
Pathogenesis
Capillaria hepatica
title_short Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
title_full Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
title_fullStr Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
title_full_unstemmed Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
title_sort Capillaria hepatica-induced septal fibrosis in rats: a contribution to the study of liver fibrogenesis
author Barbosa, Valter Lucas Chaves
author_facet Barbosa, Valter Lucas Chaves
Andrade, Zilton de Araújo
author_role author
author2 Andrade, Zilton de Araújo
author2_role author
dc.contributor.author.fl_str_mv Barbosa, Valter Lucas Chaves
Andrade, Zilton de Araújo
Barbosa, Valter Lucas Chaves
Andrade, Zilton de Araújo
dc.subject.por.fl_str_mv Hepatic fibrosis
Pathogenesis
Capillaria hepatica
topic Hepatic fibrosis
Pathogenesis
Capillaria hepatica
description p. 504-507
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2012-04-19T11:23:52Z
dc.date.available.fl_str_mv 2012-04-19T11:23:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/5642
dc.identifier.issn.none.fl_str_mv 0037-8682
dc.identifier.number.pt_BR.fl_str_mv v. 43, n. 5.
identifier_str_mv 0037-8682
v. 43, n. 5.
url http://www.repositorio.ufba.br/ri/handle/ri/5642
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv DOI: 10.1590/S0037-86822010000500006
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
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